Navigation Links
Comparative genomics reveals molecular evolution of Q fever pathogen
Date:2/2/2009

Blacksburg, Va. Scientists from the National Institute of Allergy and Infectious Diseases, Texas A&M Health Center, and the Virginia Bioinformatics Institute at Virginia Tech have uncovered genetic clues about why some strains of the pathogen Coxiella burnetii are more virulent than others.

The researchers compared the sequences of four different strains of C. burnetii, an intracellular bacterium that can cause acute and chronic Q fever in humans, to build up a comprehensive picture of the genetic architecture and content of the different genomes. The scientists examined C. burnetii strains of differing virulence to unveil clues on the genetic features associated with pathogenicity.

Q fever is considered one of the most infectious diseases in the world since inhalation of a single bacterium alone is sufficient to kick-start infection. Infection in humans typically results from contact with infected animals such as cattle, goats, and sheep. The C. burnetii bacterium targets macrophages white blood cells in the body that usually provide protection against invading pathogens. The pathogen has the remarkable ability to replicate in a lysosome-like vacuole of macrophages, an extremely harsh intracellular environment that usually protects the body from infection by breaking down invading pathogens. The chronic form of Q fever in humans is rare but can lead to heart infections that are usually deadly if untreated.

Dr. Robert Heinzen, head of the Coxiella Pathogenesis Section at the National Institute of Allergy and Infectious Disease, remarked: "Our results suggest that mobile genetic elements have played a major role in the evolution and function of the C. burnetii genome. Recombination between insertion sequence elements or jumping genes appears to have brought about large-scale generation of non-functional genes, a change that may be associated with a more pathogenic lifestyle."

In the study, the researchers sequenced the genomes of three strains of the bacteria and made a four-way comparison of C. burnetii genomic sequences. Strain virulence was associated with a smaller genome. The loss of genes was due in part to the formation of pseudogenes, evolutionary remnants of earlier genes that no longer code for functional proteins.

Kelly Williams, research investigator at VBI, commented: "A principle of our and many modern studies was first enunciated in the title of a 1965 paper by Emile Zuckerkandl and Linus Pauling, 'Molecules as documents of evolutionary history'. Genomes are the ultimate molecular documents, filled with stories that fascinate and instruct, and we can now speed-read them."

VBI Executive and Scientific Director Bruno Sobral, a co-author on the paper, remarked: "2009 is the 200th anniversary of the birth of Darwin. That's a very suitable time to step back and think about how new technologies are giving us ever more powerful ways to investigate the history and mechanism of evolution. We hope the work in the current study serves as a resource for both the Coxiella and wider infectious disease research communities interested in the evolution of pathogen virulence."

Dr. Heinzen concluded: "The results of this study provide a solid foundation upon which we can test a number of hypotheses related to C. burnetii gene function and virulence. This information will prove invaluable as we proceed to dissect, at a molecular level, events associated with Q fever pathogenesis"


'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Related biology news :

1. Mixing genomics and geography yields insights into life and environment
2. Human genomics in China
3. Nutrigenomics -- developing personalized diets for disease prevention
4. New gene variants present opportunities in nutrigenomics
5. Computation and genomics data drive bacterial research into new golden age
6. Genetic Engineering & Biotechnology News reports on the trend toward predictive toxicogenomics
7. Complete Genomics launches, becomes worlds first large-scale human genome sequencing company
8. Broad Institute awarded major grant to bolster epigenomics research
9. Review article provides tools for the Rosaceae genomics community
10. Genomics of large marine animals showcased in the biological bulletin
11. Human Genomics and Proteomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... Parallel 6 ... trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT module which ... with the physician and clinical trial team. , Using the CONSULT module, patients and ...
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
Breaking Biology Technology: