"Our next studies will investigate the function of the parkin-endophilin-A interaction, adds Dr. Fon. "We believe that, if the parkin is mutated then the proper functioning of endophilin-A will be affected as it binds parkin, thereby disrupting synaptic vesicle recycling. This could potentially lead to the death of dopamine neurons by depriving neurons of neurotransmitters necessary for neuronal survival and functioning."
"Dr. Fon's new findings will improve our understanding of the defects in the genes and proteins of people who suffer from Parkinson's disease," says Dr. Anthony Phillips, Scientific Director at the Canadian Institutes of Health Research (CIHR) Institute of Neurosciences, Mental Health and Addiction. "CIHR is proud to support research that may pave the way to innovative new therapeutic strategies to cure Parkinson's, which affects too many Canadians."
There is as yet, no known cure for Parkinson's disease. A number of drugs and clinical treatments have been developed which can help to control or minimize the symptoms of this disabling and debilitating disease.
As a world-class academic medical centre and a designated National Parkinson Foundation (NPF) Center of Excellence, The Neuro not only delivers first class clinical care but, also conducts innovative research that leads to important discoveries about the disease and significant advancements in medical care and treatments for patients.
This work was supported by CIHR, the Canadian Foundation for Innovation, the R.H. Tomlinson Fellowship program, and the Fonds de la Recherche en Sant du Qubec.
|Contact: Anita Kar|