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Common parasite may trigger suicide attempts
Date:8/16/2012

uld identify those people infected with this parasite, it could help us predict who is at a higher risk."

T. gondii is a parasite found in cells that reproduces in its primary host, any member of the cat family. It is transmitted to humans primarily through ingesting water and food contaminated with the eggs of the parasite, or, since the parasite can be present in other mammals as well, through consuming undercooked raw meat or food.

Brundin has been looking at the link between depression and inflammation in the brain for a decade, beginning with work she did on Parkinson's disease. Typically, a class of antidepressants called selective serotonin re-uptake inhibitors, or SSRIs, have been the preferred treatment for depression. SSRIs are believed to increase the level of a neurotransmitter called serotonin but are effective in only about half of depressed patients.

Brundin's research indicates a reduction in the brain's serotonin might be a symptom rather than the root cause of depression. Inflammation, possibly from an infection or a parasite, likely causes changes in the brain's chemistry, leading to depression and, in some cases, thoughts of suicide, she said.

"I think it's very positive that we are finding biological changes in suicidal patients," she said. "It means we can develop new treatments to prevent suicides, and patients can feel hope that maybe we can help them.

"It's a great opportunity to develop new treatments tailored at specific biological mechanisms."


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Contact: Jason Cody
codyja@msu.edu
517-432-0924
Michigan State University
Source:Eurekalert  

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