Navigation Links
Common herbicides and fibrates block nutrient-sensing receptor found in gut and pancreas
Date:10/9/2009

icromolar concentrations to inhibit binding of sugars to the T1R3 component of the receptor.

Additional testing revealed that the inhibitory effect of both fibrates and phenoxy-herbicides on the T1R3 receptor is specific to humans. That is, the ability of these compounds to block the receptor did not generalize across species to the rodent form of the receptor.

Mosinger commented on the implications of the findings and noted the importance of testing chemicals intended for human use on human tissues. "The metabolic consequences of short- and long-term exposures of humans to phenoxy-herbicides are unknown. This is because most safety tests were done using animals, which have T1R3 receptors that are insensitive to these compounds," he said.

The ability of fibrate drugs to interact with T1R3 receptors also was previously unknown. The study findings suggest that these receptors might be an important pharmacological target of first-generation fibrates, such as clofibrate, which were believed to act on a different receptor to affect lipid metabolism. Newer fibrate drugs are more specific for the second receptor and interact less with the T1R3 receptor.

Mosinger points out that little is known about how T1R3 blockade affects hormone levels and metabolism. "Given the number of compounds used in agriculture, medicine and the food industry that may affect human T1R3 and related receptors, more work is needed to identify the health-related effects of exposure to these compounds," he said.


'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Oxidized form of a common vitamin may bring relief for ulcerative colitis
2. The first DNA barcodes of commonly traded bushmeat are published
3. Scientists link genetic glitches to common childhood cancer
4. Study links virus to some cases of common skin cancer
5. Common allergy drug reduces obesity and diabetes in mice
6. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
7. Chemicals in common consumer products may play a role in pre-term births
8. Common fish species has human ability to learn
9. Common chemotherapy drug triggers fatal allergic reactions
10. Low levels of vitamin D linked to common vaginal infection in pregnant women
11. UNC study identifies genetic cause of most common form of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... play a bigger role than food alone, when it comes ... evidence over the past 150 years found that the effects ... override the effects of food alone on tooth decay. The ... Obesity Reviews . Professor Monty Duggal, an author ...
... Space Biomedical Research Institute (NSBRI) has selected Daniela ... one of four young investigators in the nation ... is a postdoctoral fellow in Georgetown,s Lombardi Comprehensive ... and Molecular & Cellular Biology. In the ...
... Sawyer will use a $120,000 grant from the Foundation for ... the cells it attacks have evolved together over time. The ... drugs. When HIV infiltrates cells, the virus hijacks its ... It has been recently found that the retrovirus hijacks about ...
Cached Biology News:GUMC young scientist selected postdoc Fellow at National Space Biomedical Research Institute 2Evolutionary biologist will study HIV with grant from AIDS research foundation 2
(Date:12/22/2014)... 22, 2014 GenomeDx Biosciences today announced that ... Classifier, a genomic test for prostate cancer, was able ... managed by radical prostatectomy without adjuvant therapy. Although rapid ... uncommon, using tumor genomics to identify these men who ... an important advance. The study has been published ...
(Date:12/22/2014)... 22, 2014 The American ... of original research, reviews and editorials addressing developments ... practice, today published a provocative article exploring the ... progression and potential treatment of prostate cancer. ... and proposes the possibility that there could be ...
(Date:12/22/2014)... Fertility Associates of Memphis has announced a new ... network of more than 20 contributing fertility practices ... access to a national pool of frozen donor ... of Memphis is the only fertility clinic in the ... Dr. William Kutteh , director of Fertility Associates of ...
(Date:12/19/2014)... Charm Sciences is pleased to announce ... of Aflatoxin M1 in raw commingled milk is the ... validation. The peer reviewed report of the validation by ... Agricultural and Fisheries Research (ILVO-T&V) has been published by ... the most toxic aflatoxin and a known carcinogen, can ...
Breaking Biology Technology:Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... LEXINGTON, Mass., June 24 Instrumentation Laboratory,(IL) today ... Premier 4000,critical care analyzer. The recipient for this ... IL began shipping the new GEM Premier 4000,analyzers ... The remarkable,commercial success of this breakthrough analyzer underlines ...
... IRVINE, Calif., June 24 Stason Pharmaceuticals, ... announced,today that it has appointed Diana Wood ... be responsible for all business development,functions, including ... is a senior executive with extensive experience ...
... British Columbia researchers has developed a technique that controls ... superconductors, a procedure considered impossible for the past two ... the team deposited potassium atoms onto the surface of ... the scientists to continuously manipulate the number of electrons ...
Cached Biology Technology:Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health 2Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health 3Stason Pharmaceuticals, Inc. Appoints Diana Wood as Vice President, Business Development 2UBC physicists develop 'impossible' technique to study and develop superconductors 2
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Phosphorylcholine hapten is conjugated to BSA protein by use of p-diazonium phenylphosphorylcholine....
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
Biology Products: