Navigation Links
Common genetic mutation increases sodium retention, blood pressure
Date:5/29/2012

AUGUSTA, Ga. Nearly 40 percent of the small adrenal tumors that cause big problems with high blood pressure share a genetic mutation that causes patients to retain too much sodium, researchers report.

The study of 47 human, benign adrenal gland tumors also showed a mutation of the gene KCNJ5 is twice as likely to occur in women 71 versus 29 percent as it points to potential new treatments for some patients who don't respond to current hypertension regimens, said Dr. William E. Rainey, Scientific Director of the Adrenal Center at Georgia Health Sciences University.

Addititionally, when scientists put the mutated gene into an adrenal cell, it immediately starts producing the sodium-retaining hormone aldosterone. "We found it turned on a whole series of genes that cause the cell to produce aldosterone," Rainey said.

Typically, KCNJ5 appears to help normalize levels of the sodium-retaining hormone aldosterone by regulating how much potassium is pumped in and out of aldosterone-producing cells on the outer layer of the adrenal glands. Abnormal protein produced by the mutated gene alters the cells' electrical status.

"When this gene has a mutation, the cells lose control and just start producing aldosterone all the time," said Rainey, corresponding author of the study in the Journal of Clinical Endocrinology and Metabolism.

"The combination of too much salt and too much of this hormone leads to high blood pressure and tissue damage," said Rainey. He notes that the vast majority of the 311 million Americans consume too much salt, even if they never pick up a salt shaker, because of high content in breads, processed and fast foods and the like. An estimated 33 percent of Americans are hypertensive and an estimated 1 in 10 have adrenal problems as the cause.

A 2011 study led by Yale University and published in the journal Science showed that the tumors had a KCNJ5 mutation. GHSU researchers, along wit
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study provides insight on a common heart rhythm disorder
2. Researchers identify Achilles heel of common childhood tumor
3. First comprehensive genomic study of common cold reveals new treatment targets
4. GUMC researchers hone in on new strategy to treat common infection
5. Hairspray is linked to common genital birth defect, says study
6. Common food additive found to increase risk and speed spread of lung cancer
7. Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
8. Scientists uncover evolutionary keys to common birth disorders
9. Common soil mineral degrades the nearly indestructible prion
10. Genetic testing not cost-effective in guiding initial dosing of common blood thinner
11. New vaccine developed for preventing uncommon cold virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common genetic mutation increases sodium retention, blood pressure
(Date:7/31/2015)... China , 31. Juli 2015 Die 10. ... wird von BGI veranstaltet und findet vom 22. ... China , statt. Die ... Seit ihrem Start 2006 ist die ICG weltweit ... „omik" geworden. Sie ist eines der dynamischsten, enthusiastischsten ...
(Date:7/31/2015)... SHENZHEN, China , July 31, 2015 The ... ) will be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th ... become one of the world,s most influential annual meetings in ... enthusiastic, and enjoyable scientific gatherings. ICG-10 focuses ...
(Date:7/27/2015)... JOSE, Calif. , July 27, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... ® touchscreen solution for its stylish smartwatch. ... for its proven reliability, low power and highly ... a wet finger. Huawei designers also required a ...
Breaking Biology News(10 mins):Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... at the leaves on a plant and noticed their various ... size and shape of each individual leaf? Very little is ... and understanding the mechanisms behind this is a major issue ... determined by a combination of cell number, cell size, and ...
... evolved over hundreds of generations to infect bacteria. They ... evolved at a quicker rate and generated greater diversity, compared ... the viral infection. The study shows, for the first ... correct in his ,Red Queen Hypothesis,. The theory, first ...
... What are the top research questions facing agriculture? Earlier this ... opinions of its members and leadership to develop a Grand ... ASA Grand Challenge The Society -- through a ... "Grand Challenge" statement that encompasses the future of agriculture: ...
Cached Biology News:Can a single layer of cells control a leaf's size? 2Can a single layer of cells control a leaf's size? 3Scientists reveal driving force behind evolution 2What is the 'grand challenge' facing the future of agriculture? 2
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience ... meeting of the Japan Society of HTLV-1, held this ... Auditorium. The purpose of the Society is to promote ... the development of medical technology and research related to ... welfare. "HUYA is proud to support this ...
(Date:8/27/2015)... ... 27, 2015 , ... METTLER TOLEDO's web-based EasyFinder™ ... choices to a manageable shortlist of bench and floor scales and terminals. Specifying ... best with the customer’s industry and application. , Side-by-side product comparisons and ...
(Date:8/26/2015)... ... August 26, 2015 , ... MediVet Biologics, a leader in ... is to open in Manhattan, Kansas in early October, 2015. The location of ... research and development through collaboration with researchers from Kansas State University’s College of ...
(Date:8/26/2015)... Maryland Heights, MO (PRWEB) , ... August 26, ... ... is announcing it is increasing its investment in the development and manufacture of ... increase demand. The company’s scientific team's extensive expertise with protein chemistry has ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4METTLER TOLEDO Updates Online Scale Selection Tool 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2
... The Tauri Group LLC is pleased,to announce that ... and,Technical Assistance (SETA) support for the U.S. Department ... Detection Division Chemical,and Biological Early Detection (CBED) program. ... the period of performance is three years and ...
... Dec. 11 Replikins Ltd. today announced its,latest ... H5N1 influenza,virus. The company,s software-driven analysis has found ... in Indonesia; in addition, higher,counts now have been ... this gene which has been linked to the ...
... Inventory Management, Disposables ... Colo., Dec. 11 , WHAT: This presentation identifies key challenges facing ... supplies and explains how embedded RFID ... that enhances safety and reliability, increases ...
Cached Biology Technology:The Tauri Group LLC Awarded U.S. Department of Homeland Security Chemical and Biological Early Detection Systems Program Office Support Contract 2Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated 2SkyeTek to Present Webinar on Transforming the Management of Medical Devices & Supplies with Embedded RFID 2