Navigation Links
Common gene variants account for most genetic risk for autism
Date:7/20/2014

icular cases of disease.

More challenging is to gauge the collective impact on autism risk of numerous variations in the genetic code shared by most people, which are individually much subtler in effect. Limitations of sample size and composition made it difficult to detect these effects and to estimate the relative influence of such common, rare inherited, and rare spontaneous variation.

Differences in methods and statistical models also resulted in sometimes wildly discrepant estimates of autism's heritability ranging from 17 to 50 percent.

Meanwhile, recent genome-wide studies of schizophrenia have achieved large enough sample sizes to reveal involvement of well over 100 common gene variants in that disorder. These promise improved understanding of the underlying biology and even development of risk-scores, which could help predict who might benefit from early interventions to nip psychotic episodes in the bud.

With their new study, autism genetics is beginning to catch up, say the researchers. It was made possible by Sweden's universal health registry, which allowed investigators to compare a very large sample of about 3,000 people with autism with matched controls. Researchers also brought to bear new statistical methods that allowed them to more reliably sort out the heritability of the disorder. In addition, they were able to compare their results with a parallel study in 1.6 million Swedish families, which took into account data from twins and cousins, and factors like age of the father at birth and parents' psychiatric history. A best-fit statistical model took form, based mostly on combined effects of multiple genes and non-shared environmental factors.

"This is a different kind of analysis than employed in previous studies," explained Thomas Lehner, Ph.D., chief of NIMH's Genomics Research Branch. "Data from genome-wide association studies was used to identify a genetic model instead of focusing just on
'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Genetic risk for autism stems mostly from common genes
2. Singapore scientists discover genetic cause of common breast tumours in women
3. GW and Peking University awarded funding to understand common blood coagulation disorder
4. Study identifies novel genomic changes in the most common type of lung cancer
5. Cellular gates for sodium and calcium controlled by common element of ancient origin
6. Gene variants found that increase pain sensation after common childhood surgery
7. Schizophrenia and cannabis use may share common genes
8. Africas poison apple provides common ground for saving elephants, raising livestock
9. Common BPA-like chemical, BPS, disrupts heart rhythms in females
10. ESMO survey sheds light on common clinical practice for incompletely resected lung cancer
11. Common bean genome sequence provides powerful tools to improve critical food crop
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Common gene variants account for most genetic risk for autism
(Date:9/18/2014)... PULLMAN, Wash. - Washington State University researchers have developed ... sediment to power waste cleanup in rural areas. ... lead to an inexpensive and quick way to clean ... treatment plants while reducing pollution. , Professor Haluk ... College of Engineering and Architecture discuss the system in ...
(Date:9/18/2014)... sleep-promoting circuit located deep in the primitive brainstem has ... researchers at Harvard School of Medicine and the University ... is only the second "sleep node" identified in the ... and sufficient to produce deep sleep. , Published online ... demonstrates that fully half of all of the brain,s ...
(Date:9/18/2014)... SAN ANTONIO, September 18, 2014 New research into ... which causes a severe hemorrhagic disease in humans similar ... factors essential for CCHFV infection. This discovery has the ... against the pathogen. , The research, reported ... PLoS Pathogens and conducted by scientists at the ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2Research milestone in CCHF virus could help identify new treatments 2
... the Feb. 8 PNAS supports the concept of a ... California, Israel, and Germany have compared three distantly related ... ?and reported that protein "wiring" connections in one species ... of three higher level organisms published in the February ...
... baculovirus and caterpillar cells scientists from Protein Sciences Corporation ... in the development of an experimental cell-based influenza vaccine. ... Society for Microbiology Biodefense Research Meeting. , "The bird ... could happen at any time," says Keyang Wang, a ...
... Agilent Technologies Inc. (NYSE: A) today released an ... of biological systems. The tool is available as ... bioinformatics platform that enables researchers to form a ... understanding of molecular pathways and the biological causes ...
Cached Biology News:Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits 2Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits 3Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits 4Influenza vaccine uses insect cells to speed development 2Agilent Technologies releases automated literature search tool for biology researchers 2Agilent Technologies releases automated literature search tool for biology researchers 3
(Date:9/19/2014)... rather than electricity, to move data would consume ... a growing concern as chips, transistor counts rise. ... circuits light emitters, modulators, and detectors ... light source for optical chips is molybdenum disulfide ... as a single, atom-thick layer. Other experimental on-chip ...
(Date:9/19/2014)... 2014 Biotech companies make announcements ... drug systems and advanced Laboratory Instrumentation. Companies in focus ... BDX ), Thermo Fisher Scientific Inc. (NYSE: ... RGDO ), Sangamo Biosciences Inc. (NASDAQ: ... Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" or the "Company") ...
(Date:9/19/2014)... SPRINGS, Florida , September 19, 2014 ... companies release latest developments, patents and results of studies ... GNSZ), Eli Lilly and Company (NYSE: LLY ... Celgene Corporation (NASDAQ: CELG ) and Arena ... GNSZ), a leader in developing prodrug therapeutics for the ...
(Date:9/19/2014)... DUBLIN , September 19, 2014 ... Research and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the ... Pre-packed Chromatography Columns"  report to their offering.  ... columns market is one of the fastest-growing segments ... at $1.2 billion in 2013, and expected to ...
Breaking Biology Technology:Toward optical chips 2Toward optical chips 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7Micro Market Monitor : Global Pre-packed Chromatography Columns 2
... the official language of the United States. Thats a bold move. ... ,For the first time, World Cup referees and their assistants ... order to be among the 44 officials taking part in soccers ... as its called in most of the world. But when it ...
... new phase. Both are headed to a jumpsuit jamboree courtesy of ... ex-heads of Enron - Ken Lay and Jeff Skilling - were ... of their fellow Houstonians. The duo will soon be sentenced before ... , , When Creative Becomes Criminal , ,It is ...
... company of a Florida manufacturer of radio frequency enabled ... following the signing of a bill prohibiting Wisconsin employers ... , ,Scott Silverman, chairman and CEO of Applied Digital, ... are consistent with what the law provides. "In theory, ...
Cached Biology Technology:English as the lingua franca of a new age: Its more powerful than any law 2English as the lingua franca of a new age: Its more powerful than any law 3Are there more Enrons out there? 2Are there more Enrons out there? 3Are there more Enrons out there? 4Company defends RFID implant product 2
...
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
2'-Fluorine-CTP (2'-F-CTP) is readily incorporated into transcripts by T7 and SP6 R&DNA™ Polymerase and is available separately....
Human Glypican 2 Biotinylated Affinity Purified PAb...
Biology Products: