Navigation Links
Common food preservative may slow, even stop tumor growth
Date:10/31/2012

ANN ARBORNisin, a common food preservative, may slow or stop squamous cell head and neck cancers, a University of Michigan study found.

What makes this particularly good news is that the Food and Drug Administration and the World Health Organization approved nisin as safe for human consumption decades ago, says Yvonne Kapila, the study's principal investigator and professor at the University of Michigan School of Dentistry.

This means that obtaining FDA approval to test nisin's suggested cancer-fighting properties on patients in a clinical setting won't take as long as a new therapy that hasn't been tried yet on people, she says.

Antibacterial agents like nisin alter cell properties in bacteria to render it harmless. However, it's only recently that scientists began looking to antibacterial agents like nisin to see if they altered properties in other types of cells, such as cancer cells or cells in tumors.

Oral cancer is a leading cause of death worldwide, and oral squamous cell carcinoma accounts for more than 90 percent of oral cancers. However, survival rates for oral cancer haven't improved in decades, according to the study.

"The poor five-year survival rates for oral cancer underscore the need to find new therapies for oral cancer," Kapila said. "The use of small antibacterial agents, like nisin, to treat cancer is a new approach that holds great promise. Nisin is a perfect example of this potential because it has been used safely in humans for many years, and now the laboratory studies support its anti-tumor potential."

The U-M study, which looked at the use of antimicrobials to fight cancerous tumors, suggests nisin, in part, slows cell proliferation or causes cell death through the activation of a protein called CHAC1 in cancer cells, a protein known to influence cell death.

The study is the first to show CHAC1's new role in promoting cancer cell death under nisin treatment. The f
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Commonly used herbicides seen as threat to endangered butterflies
2. Common North American frog identified as carrier of deadly amphibian disease
3. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
4. New research about facial recognition turns common wisdom on its head
5. Commonly used diabetes drug may help to prevent primary liver cancer
6. Loyola study debunks common myth that urine is sterile
7. Dental X-rays linked to common brain tumor
8. Women & Infants participating in study of treatment of common viral infection in pregnancy
9. Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
10. Modest alcohol intake associated with less inflammation in patients with common liver disease
11. Sulphur and iron compounds common in old shipwrecks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... are many viral diseases in the world for which ... fever, which is spread by mosquitoes in the tropics, ... more familiar in Finland and is easily spread by ... children and the elderly. , Researchers at Aalto University ... in preliminary tests to prevent the spread of one ...
(Date:4/15/2014)... parasites of cuttlefish, squid and octopus has uncovered ... shown how they may help in investigating populations ... has described 10 new parasite species− dicyemid mesozoans ... (cuttlefish, squid and octopus). They are the ... Australian waters. , "Although dicyemid parasites have ...
(Date:4/15/2014)... 15, 2014) New research published in the ... American College of Nutrition shows whey protein, either ... part of a weight-loss or weight-maintenance diet, may provide ... , The meta-analysis included 14 randomized controlled trials with ... those weight loss studies that used whey protein to ...
Breaking Biology News(10 mins):Nanocrystalline cellulose modified into an efficient viral inhibitor 2Bizarre parasite may provide cuttlefish clues 2New meta-analysis builds on the power of whey protein for improved body composition 2New meta-analysis builds on the power of whey protein for improved body composition 3
... pave the way for individually tailored therapiesContinuing its ... responses to medications, the National Institutes of Health ... years to renew its Pharmacogenetics Research Network (PGRN). ... will eventually help doctors tailor drug prescriptions to ...
... Research carried out with the participation of the ... molecule helps an important pathogen, Brucella abortus, escape ... agents (macrophages). This research has been published in ... model of an intracellular parasite, a category that ...
... Institution of Oceanography at the University of California, San ... Venezia Nuova and Thetis SPA, has launched a multifaceted ... effects of sediment translocation in Venice lagoon, a vital ... The new effort, a two-year, $1.5 million project for ...
Cached Biology News:NIH renews network focused on how genes influence drug responses 2NIH renews network focused on how genes influence drug responses 3NIH renews network focused on how genes influence drug responses 4New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon 2New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... The American ... 22nd in San Antonio, Texas, USA. AFS is holding its 23rd Annual Conference, March 22-25, ... courses held on March 22nd. Five of these courses are on the topics of air ... ...
... , , , WASHINGTON ... director of the National Institutes of Health and recipient of the ... a February 26 Speaker Luncheon.  Topic of his talk ... The luncheon was originally scheduled for December, but postponed because of ...
... first time the European research initiative EUREKA will be ... which forms part of HANNOVER MESSE 2010 (19-23 April). ... Market for Research and Development in Hall 2. ... makes as a central European platform with respect to ...
Cached Biology Technology:Air Filtration and Gas/Solid Separation Training by the American Filtration and Separations Society 2Air Filtration and Gas/Solid Separation Training by the American Filtration and Separations Society 3Air Filtration and Gas/Solid Separation Training by the American Filtration and Separations Society 4NIH Director Francis Collins to Speak at National Press Club February 26 on 'A New Era of Quantum Leaps in Biomedical Research' 2NIH Director Francis Collins to Speak at National Press Club February 26 on 'A New Era of Quantum Leaps in Biomedical Research' 3European research initiative EUREKA presented at Research & Technology for the first time 2
... The ApopTag Red In Situ Apoptosis ... by the indirect TUNEL method, utilizing ... fluorochrome. The kit provides indirect immunofluorescence ... analyzed using either fluorescence microscopy or ...
The sample holders for gels are used to hold gels in place in the multi-sample tray I, which is used with Molecular Imager FX imaging systems....
... gel cell is a stand-alone apparatus that ... applications. The upper buffer chamber can accommodate ... long for isoelectric focusing (IEF) applications. The ... cooling core, lower buffer chamber, lid with ...
... The ApopTag Fluorescein In Situ ... in situ by the indirect TUNEL ... is conjugated to a Fluorescein reporter ... for 40 samples. Results are analyzed ...
Biology Products: