Navigation Links
Common drugs initiate a molecular pas de quatre at the surface of the cell membrane
Date:7/26/2011

ic G protein (Gs) to fall apart in two pieces (G-alpha-S and G-beta-gamma). One piece (G-alpha-S) transmits the adrenaline signal to an effector enzyme; the other piece (G-beta-gamma) transmits the signal to an effector ion channel.

Although the receptor beta-2AR been discovered 20 years ago, the exact mechanism of its function remained unknown, impeding improvements of the drugs that act on this receptor. To explain the function of this receptor, it was important to catch the signaling complex in the act, a dance in two parts featuring four key players: the hormone (adrenaline or noradrenaline), the receptor and the G protein that is built from G-alpha-S and G beta-gamma.

Now, 20 year later, this is exactly what the researchers Stanford University, University of Wisconsin and VIB-Vrije Universiteit Brussel have accomplished. They produced two key freeze-frame pictures of this dance. In January 2011, they produced the first images of an active receptor, coupled to a drug-like molecule that acts like the hormone. In a follow-up article in Nature, they now present the poignant moment in the ballet the four-partner embrace that includes the hormone, the receptor, G-alpha-S and G-beta-gamma. These findings provide the very first three dimensional insights in transmembrane signaling trough GPCRs, a molecular process that is considered to be one of the most fascinating problems in biology. The discovery is important because the interactions between the GPCR and G-alpha-beta-gamma are pharmacologically relevant and unlock the secrets of functional selectivity, the ability of different drugs to coax distinct downstream effects from a single kind of receptor.

Obtaining a 3D image of the Hormone:GPCR:G-alpha-beta-gamma complex proved to be very complicated. The large and membrane embedded complex is unstable, difficult to prepare and the components are difficult to express and purify. Jan Steyaert and Els Pardon in Brussels produced a Xaperone, that
'/>"/>

Contact: Joris Gansemans
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study provides insight on a common heart rhythm disorder
2. Researchers identify Achilles heel of common childhood tumor
3. First comprehensive genomic study of common cold reveals new treatment targets
4. GUMC researchers hone in on new strategy to treat common infection
5. Hairspray is linked to common genital birth defect, says study
6. Common food additive found to increase risk and speed spread of lung cancer
7. Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
8. Scientists uncover evolutionary keys to common birth disorders
9. Common soil mineral degrades the nearly indestructible prion
10. Genetic testing not cost-effective in guiding initial dosing of common blood thinner
11. New vaccine developed for preventing uncommon cold virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... many sobering examples of how wildlife loss leads to ... co-authored by Wildlife Conservation Society (WCS) Health & ... Golden, calls for an interdisciplinary approach to tackle global ... supports about 15% of the world,s people and provides ... poor. It should come as no surprise that today,s ...
(Date:7/24/2014)... have decreased by 45% on average over a 35 ... a study on the impact of humans on declining ... benefits invertebrates such as insects, spiders, crustaceans, slugs and ... pest control for crops, decomposition for nutrient cycling, water ... Science and led by UCL, Stanford and ...
(Date:7/24/2014)... June 24, 2014 Some sticky research out of ... against a certain species of toxic grass fungus: moose ... month,s Biology Letters , "Ungulate saliva inhibits a ... applied to red fescue grass (which hosts a fungus ... in slower fungus growth and less toxicity. , "Plants ...
Breaking Biology News(10 mins):New study draws links between wildlife loss and social conflicts 2Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Moose drool inhibits growth of toxic fungus: York U research 2
... Portage Glacier, AK The historic collaboration between leading ... the Center for Health and the ,Global Environment at ... ,Evangelicals (NAE) continues this week with a trip to ... leaders began traveling together on August 25th to observe ...
... living donor transplantation are continuously happening in hospitals. One ... 14 issue of the World Journal of Gastroenterology because ... going to bring comfort to many families. It ... Ichikawa in the Nagasaki University Hospital, Japan in 2004. ...
... technique for testing public drinking water samples for the ... the amount of time required to conduct the sampling ... Agency (EPA) has approved use of the new testing ... director of the Georgia Tech Research Institutes (GTRI) Environmental ...
Cached Biology News:Scientist-evangelical Alaska expedition 2Clearance of hepatitis C viral infection after liver transplantation 2Safe water: simpler method for analyzing radium in water samples cuts testing time 2Safe water: simpler method for analyzing radium in water samples cuts testing time 3
(Date:7/25/2014)... WABC Radio show out of New York City, ... will be hosting California-based Vet-Stem, Inc.’s Founder and CEO, Robert ... pets. Dr. Harman first visited the show in November ... pets suffering from osteoarthritis and other degenerative diseases, as well ... , Young has invited Dr. Harman back to dial down ...
(Date:7/25/2014)... Muncie, IN (PRWEB) July 25, 2014 ... Administration (FAA) has granted a 60-day extension for the ... of the Special Rule for Model Aircraft established by ... Act of 2012. The 60-day extension establishes the new ... the United States Department of Transportation/FAA notice published in ...
(Date:7/24/2014)... , July 24, 2014  Now available is a ... Rehealth Regenerative Therapies , located in ... physically active people a new health option: stem ... of age, countless patients suffer from joint and muscle ... as muscle tears, torn rotator cuff, tennis elbow, and ...
(Date:7/24/2014)... Quantum computers have yet to materialise. Yet, scientists ... making such computers faster. One such approach relies ... controlled by applying an electric field. A new ... coherently coupled quantum dots (TQDs) with electrical impulses ... for example, should TQDs be used as quantum ...
Breaking Biology Technology:Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3FAA Grants Comment Extension at the Request of AMA 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
... BOTHELL, Wash., Nov. 18 BioLife Solutions, Inc. (OTC Bulletin ... cGMP hypothermic storage and cryopreservation media products for cells, tissues, ... Japanese patent for an application that includes claims related to ... used in biopreservation. The patent is titled " Inclusion of ...
... ... for irregular warfare--for combat, and just as importantly, for civic operations designed to gain ... to December 3. , ... Orlando, FL (Vocus) November 18, 2009 -- As the President nears a decision ...
... ... report. WellGen is developing propeirtary nutraceuticals for medical foods, a market described as a ... ... released industry analysis highlights WellGen, Inc. as an important innovator in a high growth market. ...
Cached Biology Technology:BioLife Solutions Granted Japanese Biopreservation Patent 2BioLife Solutions Granted Japanese Biopreservation Patent 3Huge Exhibition to Demonstrate Training for Irregular Warfare 2Huge Exhibition to Demonstrate Training for Irregular Warfare 3WellGen Recognized as Nutraceutical “Innovator” by Global Business Insights 2WellGen Recognized as Nutraceutical “Innovator” by Global Business Insights 3
... FL ATP-Gamma-S binds to ATP-binding proteins. ... BODIPY FL fluorophore was linked through ... to its potential use for binding ... is an important new substrate for ...
... the world of discovery races ever faster, you ... the fast track. So our constant focus is ... your research. Thats why our Biomek 3000 Laboratory ... as advanced as it is flexible. By integrating ...
... industry standard microarray image analysis software because ... analysis tools, visualizations, automation capabilities, performance and ... with every GenePix scanner, and it also ... all types of arrays. A wide range ...
... Arrays contain 60 rabbit tissue samples arrayed on ... unstained slides and 1 hematoxylin and eosin (H&E) ... 15 different tissues from 4 rabbit organisms, for ... Each tissue sample (or core) is 1.5 mm ...
Biology Products: