Navigation Links
Common 'chaperone' protein found to work in surprising way, say Scripps Research scientists
Date:4/3/2011

LA JOLLA, CA April 3, 2011 In the constantly morphing field of protein structure, scientists at The Scripps Research Institute offer yet another surprise: a common "chaperone" protein in cells thought to help other proteins fold has been shown instead to loosen them.

The study was published in the April 3 issue of Nature Structural & Molecular Biology.

The research offers the first structural insights into the shape of a "client" protein in the presence of a helper or "chaperone" protein. Specifically, the study examined the client protein p53 tumor suppressor and its interactions with chaperone heat shock protein 90 (Hsp90).

"It was a real surprise to find that, when bound to Hsp90, p53 is loosened and becomes less ordered, forming a molten globule-like state," said the study's lead investigator, molecular biologist Professor H. Jane Dyson. "This contradicts what everyone thought of as the function of chaperone proteinsto help other proteins fold into a well-defined three-dimensional structure."

Appreciating Versatility

The findings add to scientists' new understanding of proteins, now thought not only to constantly change shape to perform different functions, but also to be active when unfolded.

It was once thought that proteins could be active only if they were neatly folded into a compact shape and that this structure defined its function. Then Scripps Research investigators Dyson and Professor Peter Wright, as well as others, discovered that unfolded "disordered" proteins (also known as "intrinsically unstructured proteins") could also be active.

One way these intrinsically disordered proteins act is by folding when they bind to other molecules and performing a function such as potentiating cellular signaling or turning on the transcription of a gene.

The disordered protein might then dissociate from this partner, unfold, and perhaps bind to a different molecule in a new shape. Thus, these protei
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study provides insight on a common heart rhythm disorder
2. Researchers identify Achilles heel of common childhood tumor
3. First comprehensive genomic study of common cold reveals new treatment targets
4. GUMC researchers hone in on new strategy to treat common infection
5. Hairspray is linked to common genital birth defect, says study
6. Common food additive found to increase risk and speed spread of lung cancer
7. Mayo Clinic: Brain disorder suggests common mechanism may underlie many neurodegenerative diseases
8. Scientists uncover evolutionary keys to common birth disorders
9. Common soil mineral degrades the nearly indestructible prion
10. Genetic testing not cost-effective in guiding initial dosing of common blood thinner
11. New vaccine developed for preventing uncommon cold virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... have identified a handful of bacterial culprits that may ... and ulcerative colitis, using patients, own intestinal immune responses ... 28 in the journal Cell . , Trillions ... plays a critical role in the development and progression ... number of bacterial species affect a person,s susceptibility to ...
(Date:8/28/2014)... Clinic researcher and his collaborators have developed an online ... process of re-engineering cells for biomedical investigation. CellNet is ... to aid stem cell engineering. Details of CellNet and ... two back-to-back papers in the journal Cell . ... uses for all types of cell-based investigations and can ...
(Date:8/28/2014)... 28, 2014  Privacy Advocate and Senior Staff Attorney ... , joins the lineup of biometric and mobile commerce ... UnPlugged Executive Summit in Tampa, Florida ... announced speakers include Steven Rahman, Director, Technology and Strategy at ... Experian. The theme of this year,s event is Mobility ...
Breaking Biology News(10 mins):Yale study identifies possible bacterial drivers of IBD 2New tool aids stem cell engineering for medical research 2Biometrics UnPlugged Welcomes the Electronic Frontier Foundation's Jennifer Lynch to the Mobility at the Crossroads of Commerce and Privacy Summit 2
... Montreal researchers has discovered that GCN2, a protein in ... long-term memory, may be a master regulator of the ... control of hippocampal synaptic plasticity and memory by the ... 25th issue of the journal Nature, provides the first ...
... motors are nanoscale engines which move along very thin rod-like ... molecular cargo within biological cells. Both motors and filaments can ... transport systems. In order to increase the flux of the ... of motors that contribute to this transport but, at the ...
... ingenious mechanism used by a particular enzyme to modify ... to designing a new kind of drug that could ... will be published in the May 6 issue of ... years that an enzyme called Dam (DNA adenine methyltransferase) ...
Cached Biology News:Montreal researchers probe the genetic basis of memory 2Motor transport in bio-nano systems 2Motor transport in bio-nano systems 3Motor transport in bio-nano systems 4Scientists take aim at virulent bacteria by decoding machinery of key control enzyme 2
(Date:8/28/2014)... August 28, 2014 SPIE Fellow Glenn ... and Optical Science and Director of the Center for ... Carolina at Charlotte, and co-founder and Chairman of the ... as the 2015 Vice President of SPIE, the international ... Philip Stahl announced recent election results at the Annual ...
(Date:8/28/2014)... spintronics, an electronic which is not only based ... their spin and the spin-related magnetism. Spin-charge converters ... and vice versa. Recently, the research group of ... at Johannes Gutenberg University Mainz in collaboration with ... for the first time realised a new, efficient ...
(Date:8/28/2014)... WA (PRWEB) August 28, 2014 Sterlitech ... Filtration’s polymeric membranes to its stable of products ... available molecular weight cut-offs and include membrane filters with ... steady increase in customer demand for our membrane process ... greater variety of flat sheet membranes,” explains Sterlitech President ...
(Date:8/28/2014)... Earlier this month, a report was created ... U.S. Air Force on the performance of vehicles using ... type of fuel made from mustard seeds, offered great ... America’s Eco friendly future. In fact, every branch of ... independent of foreign oil over the next few years. ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... , , Multiporator / Electroporator 2510 , , , , , , ... Transformation Protocol , Protocol No. 4308 915.541 03/2002 , , ... , , , Microorganism , ... Cell type , Bacteria, gram positive, ...
... , , , , , , , , ... Protocol No. 4308 915.533 01/2002 , , , , , ... , Microorganism , Staphylococcus aureus, ... Bacteria, gram positive, , , ...
... Multiporator / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.532 01/2002 , , , ... , Microorganism , ... Cell type , Bacteria, gram negative, , ...
Cached Biology Technology:Streptococcus salivarius 2Staphylococcus aureus 2Salmonella typhimurium 2
Form: Ready to use Applications: ELISA...
RABBIT ANTI HALOPERIDOL...
Recombinant Mouse Serpin A1/alpha-1-Antitrypsin, CF Protein Family: Coagulation, Serine Protease Regulators...
ANTI S. GROUP AG:H...
Biology Products: