Navigation Links
Common allergy drug reduces obesity and diabetes in mice
Date:7/26/2009

fen fumarate; and the fourth was both given the drug and switched to a healthy diet.

While symptoms of the second group improved moderately, the third group demonstrated dramatic improvements in both body weight and diabetes. The fourth group exhibited nearly 100 percent recovery in all areas.

To bolster these findings, Shi and colleagues then took a group of mice whose ability to produce mast cells was genetically impaired. Despite three months of a diet rich in sugar and fat, these mice neither became obese nor developed diabetes.

"The best thing about these drugs is that we know it's safe for people," says Shi. "The remaining question now is: Will this also work for people?"

Shi now intends to test both cromolyn and ketotifen fumarate on obese and diabetic non-human primates.

Beyond friendly fire

In findings independent of Shi, researchers at Harvard Medical School and Joslin Diabetes Center discovered that a class of immune system cells called regulatory T cells, or Tregs, were abundant in the abdominal fat tissue of normal-weight humans and mice, but were virtually absent in the same tissue from obese and diabetic humans and mice.

Their numbers were inversely correlated with the numbers of a class of inflammatory immune cells, macrophages, in a sense creating parallel universes of fat. While obese and diabetic fat tissue was full of inflammatory macrophages and nearly absent of Tregs, normal-weight fat tissue was the diametric opposite.

"For immunologists this is very important, because Tregs had always been thought to control other T cells and that's it," says Markus Feuerer, a postdoctoral researcher in the lab of HMS professors of pathology Diane Mathis and Christophe Benoist. "But this is an entirely new concept." Mathis and Benoist collaborated on the study with Steven Shoelson, HMS professor of medicine at the Joslin Diabetes Center.

"I come at this studying the
'/>"/>

Contact: David Cameron
communications@hms.harvard.edu
617-432-0442
Harvard Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
2. Chemicals in common consumer products may play a role in pre-term births
3. Common fish species has human ability to learn
4. Common chemotherapy drug triggers fatal allergic reactions
5. Low levels of vitamin D linked to common vaginal infection in pregnant women
6. UNC study identifies genetic cause of most common form of breast cancer
7. Poor treatment for common vertebral compression fractures
8. Common fragrance ingredients in shampoos and conditioners are frequent causes of eczema
9. Psychiatric disorders are common in adults who have had anorexia
10. Gene exchange common among sex-manipulating bacteria
11. Common gene variants influence risk factor for sudden cardiac death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
(Date:3/24/2015)...   NexID Biometrics LLC, whose spoof-mitigation technology ... announced the beginning of shipments of version 2.0 of ... company, based in Potsdam, N.Y. , ... which began here today at the Walter E. Washington ... its SDK boosts the accuracy rate range to 96.5 ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... are important vehicles for the transmission of enteric ... including human pathogens, are particularly abundant in bivalve ... procedures, thus representing a potential risk for human ... to affect the persistence of vibrios in these ...
... population of North Pacific right whales, found during the summer ... whale populations in the world. Commercial whaling in the 1800s ... these whales have been recognized as a different species from ... the Southern Hemisphere. , To help define areas and ecological ...
... in northern China starting as far back as 2400 ... farming combined with other crops, says University of Toronto ... with Chinese agriculture, most archeologists have, until recently, thought ... food associated with northern China. However, recent archeological research ...
Cached Biology News:Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host. 2Habitat use by North Pacific right whales, Eubalaena japonica, in the Bering Sea and Gulf of Alaska 2
(Date:4/23/2015)... 2015 ReliantHeart's HeartAssist5® Ventricular Assist Device ... through the device) in real time, and this data ... leading provider of Machine to Machine (M2M) communications for ... via VADLink.com can be monitored by a ... in flow below a minimum threshold, the patient can ...
(Date:4/22/2015)... PITTSBURGH , April 23, 2015  The ... the 20 th Heinz Awards, which will ... six exceptional Americans for their creativity and determination ... and abroad. This year,s recipients include ... anxieties of modern-day life and personal relationships; two ...
(Date:4/22/2015)... , April 22, 2015 /PRNewswire/ - BioAmber Inc. (NYSE and EURONEXT Paris:BIOA) today ... first quarter 2015 on Thursday, May 7, 2015 after ... a webcast and conference call for 4.30 pm ET ... Live audio of the conference call will be ... investors, members of the news media and the general ...
(Date:4/22/2015)... Today, DuPont announced it has ... microbiome discovery company. This acquisition will build on ... both seed and crop protection to discover and ... , “In 2014, the businesses in DuPont’s Agriculture, ... more than $1 billion in biological solutions across ...
Breaking Biology Technology:From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 2From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 3From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 4From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 5From a Scientist Who Develops Human Microlivers to a New Yorker Cartoonist Who Masterfully Depicts the Humor and Heartbreak of Everyday Life: The 20th Heinz Awards Honors Six Changemakers 6BioAmber Announces Webcast of Fiscal First Quarter 2015 Financial Results 2DuPont Acquires Taxon Biosciences, Inc. 2DuPont Acquires Taxon Biosciences, Inc. 3DuPont Acquires Taxon Biosciences, Inc. 4
... BUENOS AIRES, Argentina, March 30 The Development Group ... met in the city of Buenos Aires in order ... Criteria." , (Logo: ... document will be formally submitted at the 4th International,Conference ...
... CRANBURY, N.J., March 30 Amicus Therapeutics (Nasdaq: ... Matthew R. Patterson, will be presenting at the upcoming 16th ... Biotech Industry conference at New York City,s Millennium Broadway ... to begin on Thursday, April 2, 2009 at 9:30 a.m. ...
... March 30 InterMune, Inc. (Nasdaq: ITMN ) ... and President of InterMune, will present at Citi,s 4th Annual ... at 10:40 a.m. EDT. To access a live audio ... log on to the investor relations page of InterMune,s corporate ...
Cached Biology Technology:International Soy Experts Meeting in Argentina Called by the Round Table on Responsible Soy Association (RTRS) 2