Navigation Links
Common allergy drug reduces obesity and diabetes in mice
Date:7/26/2009

row increasingly deaf to insulin signals and thus lose their ability to metabolize glucose. In both cases, glucose mounts in the blood, at times to fatal levels.

But it is becoming increasingly clear that we should also think of type 2 diabetes in the context of immune function, Harvard scientists assert.

Guo-Ping Shi, Biochemist from the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, began to suspect such a connection when, in a previous study, he found mast cells present in a variety of inflammatory vascular diseases.

Mast cells are immune cells that facilitate healing in wounded tissue, primarily by increasing blood flow to the site. However, in certain conditions mast cells build up to levels far beyond what the body needs. As a result these cells become unstable and eventually, like punctured trash bags, leak molecular "garbage" into the tissue. This can result in chronic inflammation that causes asthma and certain allergies.

As Shi and postdoctoral research fellow Jian Liu discovered, mast cells were far more abundant in fat tissue from obese and diabetic humans and mice than they were in normal weight fat tissue. This led to an obvious question: by regulating mast cells, could we then control the symptoms?

To find out, Shi and colleagues took a group of obese and diabetic mice and, for a period of two months, treated them with either ketotifen fumarate (also called Zaditor) or cromolyn, both over-the-counter allergy drugs.

"We knew from published research that both cromolyn and Zaditor help stabilize mast cells in people suffering from allergy or asthma," said Shi. "It's almost as if the drugs place an extra layer of plastic on the ripped trash bag. So it seemed like a logical place to begin."

The mice were divided into four groups. The first was the control group; the second group was simply switched to a healthy diet; the third was given cromolyn or ketoti
'/>"/>

Contact: David Cameron
communications@hms.harvard.edu
617-432-0442
Harvard Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
2. Chemicals in common consumer products may play a role in pre-term births
3. Common fish species has human ability to learn
4. Common chemotherapy drug triggers fatal allergic reactions
5. Low levels of vitamin D linked to common vaginal infection in pregnant women
6. UNC study identifies genetic cause of most common form of breast cancer
7. Poor treatment for common vertebral compression fractures
8. Common fragrance ingredients in shampoos and conditioners are frequent causes of eczema
9. Psychiatric disorders are common in adults who have had anorexia
10. Gene exchange common among sex-manipulating bacteria
11. Common gene variants influence risk factor for sudden cardiac death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... traditional cigarettes, but still release toxins into the ... , Scientists studying secondhand smoke from e-cigarettes discovered ... particles, with close-to-zero exposure to organic carcinogens. However, ... second-hand e-cigarette smoke were found to be significantly ... of polycyclic aromatic hydrocarbons cancer-causing organic compounds ...
(Date:8/28/2014)... and his collaborators have developed an online analytic tool ... re-engineering cells for biomedical investigation. CellNet is a free-use ... stem cell engineering. Details of CellNet and its application ... papers in the journal Cell . , "This ... all types of cell-based investigations and can potentially offer ...
(Date:8/28/2014)... MD FASEB MARC (Maximizing Access to Research ... for the Genetics Society of America,s 27th Annual ... October 3, 2014 in Pacific Grove, California. ... of students, post doctorates and scientists from underrepresented ... community and to encourage the participation of young ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2New tool aids stem cell engineering for medical research 2
... ITHACA, N.Y. When it comes to potentially doubling the ... may be in the spit. Researchers at Cornell University, ... of Colombia, have discovered that when a major South American ... The secret to this increased yield, they write in the ...
... Mich. Solar power might be nature,s most plentiful and ... lure water insects away from critical breeding areas, a Michigan ... or other methods to break up the polarized reflection of ... likely to deposit eggs on the panels thinking that they ...
... and others interested in the chemical sciences are invited to ... (ACS) Webinars, focusing on tips on how to improve your ... Thursday, June 3, from 2 3 p.m. EDT, the ... for "Effective Technical Writing Short Course" offered by the ACS ...
Cached Biology News:To double spud production, just add a little spit 2Solar panels can attract breeding water insects 2
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
(Date:8/28/2014)... August 28, 2014 The ability for ... culture that will allow individuals to perform at the ... important for employers looking to compete in this post–recession ... embracing this trend, as the sector increasingly focuses on ... company, which will have real results on the organization's ...
(Date:8/28/2014)... 2014 Sterlitech is proud to announce ... its stable of products . These additional ... and include membrane filters with surface charges. ... demand for our membrane process testing equipment, and correspondingly, ... sheet membranes,” explains Sterlitech President Mark Spatz. “The ...
(Date:8/28/2014)... August 27, 2014 Scientists, researchers, and ... SPIE Laser Damage 2014 symposium. Marking its ... high-power lasers will run 14-17 September. The event is ... and photonics . , The premier conference for basic ... damage to optical materials will engage researchers and engineers ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... Inc. and flexcipio s.a. are pleased to ... Clinical Conductor Clinical Trial Management System (CTMS) and ... aligns the industry,s most comprehensive enterprise CTMS, with ... the best tools to optimize efficiency, productivity, and ...
... April 14 /PRNewswire/ - ImmunoVaccine Technologies Inc. (IVT), ... of a 3-year research agreement with Defence Research ... the preclinical application of IVT,s DepoVax(TM) vaccine formulation ... prevent, prepare for, and respond to biological threats. ...
... Showing Statistically Significant Improvement in Overall Survival -- First ... Data to be Presented at Plenary Session at Upcoming ... Call Today at 9:00 AM ET -SEATTLE, April 14 ... today that the pivotal Phase 3 IMPACT study of ...
Cached Biology Technology:Bio-Optronics Adds Innovative Electronic Data Capture (EDC) Solution to Clinical Conductor Clinical Trial Management System (CTMS), Continues to Improve Workflow and Productivity 2ImmunoVaccine Technologies Collaborates with Defence Research & Development Canada to Strengthen Canada's Ability to Deal with Biological Threats 2PROVENGE Significantly Prolongs Survival in Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study 2PROVENGE Significantly Prolongs Survival in Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study 3PROVENGE Significantly Prolongs Survival in Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study 4
Recombinant Porcine IL-1 alpha/IL-1F1, CF...
... Immunogen KLH-conjugated, synthetic ... 54-75 (RRGPHRNPG-PGDDDGQRSRSSS) of mouse p19ARF. ... to amino acids 62-75. Clone ... Routinely evaluated by immunoblot. ...
... siSolutions siRNA Custom Synthesis ... effective duplex RNA to knockdown ... 21-mers (19 RNA base pairs ... recently-published 27-mers, or other lengths ...
Request Info...
Biology Products: