Blacksburg, Va. -- A new technology, using electric pulses to destroy cancer tissue and named by NASA Tech Briefs as one of seven key technological breakthroughs of 2007, is receiving additional support aimed at moving the procedure to the marketplace. One of its lead developers, Rafael V. Davalos, a faculty member of the Virginia TechWake Forest University School of Biomedical Engineering and Sciences (SBES), received a $240,000 grant from the Wallace H. Coulter Foundation and $25,000 from the Wake Forest Comprehensive Cancer Center.
Davalos' grant from Coulter is an Early Career Translational Research Award in Biomedical Engineering. This early career awards program provides funding for assistant professors in established biomedical engineering departments within North America. The award seeks to support biomedical research that Coulter considers promising with the goal of progressing toward commercial development.
The technology, irreversible electroporation (IRE), was invented by Davalos and Boris Rubinsky, a bioengineering professor at the University of California, Berkeley.
Electroporation is a phenomenon that increases the permeability of a cell from none to a reversible opening to an irreversible opening. With the latter, the cell will die. For decades, biologists have used reversible electroporation in laboratories to introduce drugs and genes into cells while trying to avoid irreversible electroporation. By contrast, biomedical engineers Davalos and Rubinsky are now using irreversible electroporation to target cancer cells in the body.
IRE would be a minimally invasive surgical focal-ablation technique that could remove the undesirable tissue without the use of heat such as radiation. The IRE procedure involves placing small needles near the targeted region. The needles deliver a series of low energy microsecond electric pulses to the targeted tissue and the area treated can be monitored in real time using ultra
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