Navigation Links
Commands from the matrix
Date:5/6/2013

Environment moulds behaviour - and not just that of people in society, but also at the microscopic level. This is because, for their function, neurons are dependent on the cell environment, the so-termed extracellular matrix. Researchers at the Ruhr-Universitt have found evidence that this complex network of molecules controls the formation and activity of the neuronal connections. The team led by Dr. Maren Geiler und Prof. Andreas Faissner from the Department of Cell Morphology and Molecular Neurobiology reports in the "Journal of Neuroscience" in collaboration with the team of Dr. Ainhara Aguado, Prof. Christian Wetzel and Prof. Hanns Hatt from the Department of Cell Physiology.

Neurons and astrocytes in culture

In cooperation with Prof. Uwe Rauch from Lund University in Sweden, Bochum's biologists examined cells from the brains of two mouse species: a species with a normal extracellular matrix and a species which lacked four components of the extracellular matrix due to genetic manipulation, namely the molecules tenascin-C, tenascin-R, neurocan and brevican. They took the cells from the hippocampus, a brain structure that is crucial for the long-term memory. The team not only examined neurons but also astrocytes, which are in close contact with the neurons, support their function and secrete molecules for the extracellular matrix.

Formation, stability and activity of the neuronal connections depend on the matrix

The researchers cultivated the neurons and astrocytes together for four weeks with a specially developed culture strategy. Among other things, they observed how many connections, known as synapses, the neurons formed with each other and how stable these were over time. If either the astrocytes or the neurons in the culture dish derived from animals with a reduced extracellular matrix, these synapses proved to be less stable in the medium term, and their number was significantly reduced. Together with the Department of Cell Physiology at the RUB and the University of Regensburg, the team also showed that the neurons with a mutated matrix showed lower spontaneous activity than normal cells. The extracellular matrix thus regulates the formation, stability and activity of the neuronal connections. The researchers also examined a special structure of the extracellular matrix, the so-called perineuronal nets, which the Nobel laureate Camillo Golgi first described more than a century ago. They were significantly reduced in the environment of genetically modified cells.


'/>"/>

Contact: Dr. Andreas Faissner
Andreas.Faissner@rub.de
49-234-322-8851
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Making sense out of the biological matrix of bipolar disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... ... an biological outbreak is about to be eliminated, said Lyle Probst, President, CEO ... FireflyDX™ technologies different than other pathogen detection solutions, Probst said, “Sample ...
(Date:9/19/2017)... Sunnyvale, California (PRWEB) , ... September 19, 2017 ... ... cell biology technologies, today announced a partnership with Cytena GmbH to launch the ... technology and real-time image analysis to isolate single cells and provide visual documentation ...
(Date:9/18/2017)... ... 18, 2017 , ... Transportable biomass conversion facilities and the ... is the topic of a September 27 webinar hosted by the ... transportable biomass conversion facilities for producing biochar, briquettes, and torrefied wood, biomass supply ...
(Date:9/18/2017)... (PRWEB) , ... September 18, 2017 , ... ... innovation and business process optimization firm for the life sciences and healthcare industries, ... ServiceMax Maximize 2017 conference. , What: Digital Transformation in Medical Device – The ...
Breaking Biology Technology: