Navigation Links
Comeback of an abandoned antibiotic
Date:3/19/2014

itive to the agent. "This shows that trimethoprim is indeed effective in many cases of Streptococcus pyogenes infection," Nitsche-Schmitz said.

The focus of his team was also on samples, in which the bacteria failed to respond to the agent. They discovered two types of resistance. "Spontaneous mutations can occur in the gene for dihydrofolate reductase rendering trimethoprim no longer able to attack the changed enzyme, which means it becomes ineffective," Nitsche-Schmitz explained. The team from Braunschweig detected a specific mutation in this gene in many samples, which renders streptococci resistant. In addition, bacteria can transfer copies of changed variants of the dihydrofolate reductase gene to other bacteria. This process called horizontal gene transfer allows resistance to spread very rapidly. The scientists found two genes of this type to be further causes of insensitivity.

The study shows that the antibiotic trimethoprim is a therapeutic option for Streptococcus pyogenes infections in some geographical regions of the world. The frequency of resistance is much lower than previously believed and the medication is inexpensive, stable and effective in Staphylococcus aureus co-infections. "However, it is like a sword that can loose its sharpness quickly," Nitsche-Schmitz said. "We found three causes for the rapid spread of resistance. It is important that trimethoprim, like all antibiotics, is not prescribed without need and that patients take the agent in accordance with the instructions given."


'/>"/>

Contact: Birgit Manno
presse@helmholtz-hzi.de
49-053-161-810
Helmholtz Centre for Infection Research
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Crowdsourcing to kickstart comeback from ash dieback
2. University of Californias unofficial favorite sea slug poised to make a comeback
3. An extinct frog makes a comeback in Israel
4. Stanford scientists probe abandoned mine for clues about permanent CO2 sequestration
5. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
6. Exposure to antibiotics linked to severity of allergic asthma: UBC research
7. Team discovers how bacteria resist a Trojan horse antibiotic
8. New antibiotic could make food safer and cows healthier
9. Hot on the trail of metabolic diseases and resistance to antibiotics
10. University of Nevada, Reno first to show transgenerational effect of antibiotics
11. Bacteria discovery could lead to antibiotics alternatives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Comeback of an abandoned antibiotic
(Date:7/24/2014)... a smog-free Los Angeles, where electric cars ply silent ... on heat from beneath the earth, from howling winds ... Stanford study finds that it is technically and economically ... powered by clean, renewable energy. Published in Energy ... inexpensive and reliable energy supply in California that could ...
(Date:7/24/2014)... TORONTO, June 24, 2014 Some sticky research out ... fight against a certain species of toxic grass fungus: ... this month,s Biology Letters , "Ungulate saliva inhibits ... when applied to red fescue grass (which hosts a ... results in slower fungus growth and less toxicity. , ...
(Date:7/24/2014)... of researchers has developed a new nanoscale agent for ... for assessing the function and properties of the GI ... and treatment of gut diseases. , Illnesses ... and inflammatory bowel disease all occur in the intestine ... with diseases such as diabetes and Parkinson,s. , ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4Moose drool inhibits growth of toxic fungus: York U research 2New imaging agent provides better picture of the gut 2
... August 13, 2012 ─ (BRONX, NY) ─ Scientists at ... made a discovery involving mice and humans that could mean ... cancer, are a step closer to new treatment options. Their ... "We have discovered that a gene called HLX is expressed ...
... temperatures of the atmosphere are rising; the average temperatures ... sensititvely to these changes. The transitional zones between shallow ... store a huge amount of methane hydrates in the ... low temperatures and under high pressure. When the water ...
... up to 50 per cent of chocolate,s fat content with ... much of the cocoa butter and milk fats that go ... measuring under 30 microns in diameter. , They infused orange ... what is known as a Pickering emulsion. , Crucially, the ...
Cached Biology News:Gene discovery could improve treatment for acute myeloid leukemia 2Are methane hydrates dissolving? 2Fruity science halves fat in chocolate 2
(Date:7/24/2014)... , July 24, 2014 SRI International has ... the National Institute of Allergy and Infectious Diseases (NIAID), ... preclinical development of potential therapies for HIV infection and ... treat HIV and AIDS and the complications and opportunistic ... for preventing sexual transmission of HIV. ...
(Date:7/24/2014)... 2014 WIRB-Copernicus Group ® ("WCG")™, ... review services for clinical research, announced today that ... of Richmond, VA -based Alliance ... biosecurity consulting firm in the United ... division – WCG Biosafety™ – will be able ...
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/23/2014)... BioSciences, Inc. (NASDAQ: SGMO ) today reported ... For the second quarter ended June 30, ... million, or $0.10 per share, compared to a net ... the same period in 2013. As of June 30, ... and interest receivable of $236.7 million. Revenues ...
Breaking Biology Technology:National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9
... Madison, Wis. Ten $1,000 scholarships and a top ... for young entrepreneurs in a business-plan competition sponsored by ... Young Entrepreneur Foundation . , ,The contest, named Plan for ... students until May 31. They'll be judged by an independent ...
... now are legally obligated to notify customers when their ... require businesses to rethink the way they both protect ... 164, signed into law Thursday by Governor Jim Doyle, ... typically occurs when computer systems are hacked, when dishonest ...
... nation in the number of Sloan Foundation Fellowships in ... year is up to seven, from the two Sloans ... on young researchers in the fields of chemistry, computer ... Fellowships carry a two-year, $45,000 stipend. , ,The winners ...
Cached Biology Technology:Businesses can't hide personal information losses, theft 2UW-Madison has 7 Sloan research fellows, top in nation 2
Immunogen: Purified native p24 from strain IIIB. Storage: -20 C, Avoid Freeze/Thaw Cycles...
EDG-1CT (endothelial cell differentiation gene-1, C terminal)...
Request Info...
... Kir2.1 protein. The epitope is specific ... in any other known protein.,SPECIES REACTIVITIES: ... in rabbit, bovine, porcine and guinea ... rat and mouse (17/19 residues) and ...
Biology Products: