Navigation Links
Combo therapies tested to overcome drug resistance in melanoma patients
Date:8/2/2011

ach to developing combination therapies. The key was to figure out how to combine the molecules so that the cancer cannot get around them. Why wait for the cancer to escape? Let's block all the pathways right from the start."

Lo said this study highlights the need not only to identify mechanisms of acquired resistance to targeted inhibitors, but also to understand the signaling network associated with each mechanism to generalize potential translatable approaches to overcome drug resistance.

Once the right combinations of drugs were used together, the inhibitors "consistently triggered cell death in a highly efficient and consistent manner," the study states. "Together, our findings offer a rational strategy to guide clinical testing in pre-identified subsets of patients who relapse during treatment with BRAF inhibitors."

Lo said a clinical trial could be planned that first examines the patients' cancers to identify the resistance mechanisms at play. Those patients could then be funneled into a study pairing the inhibitors that target those specific pathways. Patients with other resistance mechanisms at work would be placed in studies testing inhibitors specific to their resistance mechanisms.

The next step, Lo said, is to identify all the mechanisms of resistance in this form of melanoma.


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Adjuvant combo shows potential for universal influenza vaccine
2. Graphene and spintronics combo looks promising
3. UT Southwestern researchers use drug-radiation combo to eradicate lung cancer
4. Triple-combo drug shows promise against antiviral-resistant H1N1, UAB researcher says
5. New discovery brings customized tuberculosis therapies based on genotype closer to reality
6. Therapies to improve biochemical functions hold promise as treatments for autism
7. Can we get there from here? Translating stem cell research into therapies
8. New mouse model may lead to new therapies for degenerative diseases
9. Study finds therapies using induced pluripotent stem cells could encounter immune rejection problems
10. NIH researchers create comprehensive collection of approved drugs to identify new therapies
11. Go figure: Math model may help researchers with stem cell, cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. ... human interface solutions, today announced that four of ... Match-in-Sensor solution, have officially been named FIDO Certified™ ... part of the certification, Synaptics, Natural ID™ fingerprint ... Universal Authentication Framework (UAF) standard and are interoperable ...
(Date:8/6/2015)... , Aug. 6, 2015  Today, U.S. Congressman ... Crossmatch ™ to learn firsthand how Silicon ... data. Crossmatch is a world leader in multi-factor ... expertise are helping federal agencies and commercial organizations ...   "The vast majority of network ...
(Date:8/5/2015)... ALBANY, New York , August 5, 2015 /PRNewswire/ ... new market report titled "Facial Recognition Market - Global ... - 2022", the global market for facial recognition is ... market is driven by increased demand for surveillance systems ... to the rising number of crimes and terrorist activities ...
Breaking Biology News(10 mins):Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3Rep. Honda to Visit Crossmatch in Redwood City 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6
... depends not only on the qualities of their teacher and ... relationship with their caregivers. That,s the finding of a new ... children in full-day child care. Cortisol, the primary stress ... in the early morning and gradually declines over the course ...
... hurdle to calculating how much carbon dioxide (CO2) is ... how the biosphere responds to stress and for determining ... by human activities. The problem is that ecosystems simultaneously ... that the compound carbonyl sulfide, which plants consume in ...
... Just after Americans have headed to the polls to elect ... issue of Current Biology , a Cell Press publication, ... of the time they reach a consensus to go for ... out that stickleback fish preferred to follow larger over smaller ...
Cached Biology News:In child care, relationships with caregivers key to children's stress levels 2Corralling the carbon cycle 2Fish choose their leaders by consensus 2Fish choose their leaders by consensus 3
(Date:9/2/2015)...  Neurotech Pharmaceuticals, Inc., announced today the first ... 2 clinical trial of NT-503 Encapsulated Cell Therapy ... choroidal neovascularization secondary to age related macular degeneration ... growth factor (VEGF) receptor protein continuously produced by ... proof-of-concept study will evaluate NT-503 ECT as a ...
(Date:9/2/2015)... NESS ZIONA, Israel , September ... BVXV, TASE: BVXV) today announced the intent of the National ... U.S. National Institutes of Health (NIH) within the Department of ... 2 trial to be held in the United ... examine the use of BiondVax,s universal flu vaccine candidate, Multimeric-001 ...
(Date:9/2/2015)... San Diego, CA (PRWEB) , ... September 02, ... ... from troubleshooting faults in manufacturing equipment, to creating professional commercial video content, to ... beautifully detailed views of fascinating events that go by too quickly to process ...
(Date:9/1/2015)... , Sept. 1, 2015  ContraVir Pharmaceuticals, Inc. (NASDAQ: ... development and commercialization of targeted antiviral therapies, announced today ... 17 th Annual Global Investment Conference sponsored by ... 8-10, 2015 at The St. Regis Hotel in ... James Sapirstein , Chief Executive Officer, will provide ...
Breaking Biology Technology:Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 2Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 3Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 4BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 2Fastec Introduces the Quad-HD TS5-Q High-Speed Camera 3ContraVir to Present at Rodman & Renshaw 17th Annual Global Investment Conference 2
... the launch of the FBRM® C35, designed to ... ... ... probe-based FBRM (Focused Beam Reflectance Measurement) technology the ...
... systems in product design and development, manufacture, ... ... Md., Oct. 1 Cylex has announced receipt of,certification ... with the Canadian Medical Devices Conformity Assessment,System (CMDCAS). These ...
... Million Strategic Investment in PharmAthene, ANNAPOLIS, Md., ... a biodefense company developing medical countermeasures,against biological and ... a strategic alliance with Panacea Biotec Ltd., that ... Biotec, through its,subsidiary, Kelisia Holdings Ltd., of $13.1 ...
Cached Biology Technology:Monitor Granule Growth in Process with the FBRM C35 2Cylex(TM) Receives ISO 13485:2003 and 9001:2000 Quality Certifications 2PharmAthene and Panacea Biotec Ltd. Establish Strategic Alliance in Biodefense and Emerging Infectious Diseases 2PharmAthene and Panacea Biotec Ltd. Establish Strategic Alliance in Biodefense and Emerging Infectious Diseases 3PharmAthene and Panacea Biotec Ltd. Establish Strategic Alliance in Biodefense and Emerging Infectious Diseases 4PharmAthene and Panacea Biotec Ltd. Establish Strategic Alliance in Biodefense and Emerging Infectious Diseases 5
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Guava has made microcapillary flow cytometry accessible ... experts alike will appreciate the latest addition ... Pluseasy to use, surprising affordable, and very ... system includes such features as absolute cell ...
...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Biology Products: