Navigation Links
Combining two genome analysis approaches supports immune system contribution to autism
Date:12/6/2012

Researchers using novel approaches and methodologies of identifying genes that contribute to the development of autism have found evidence that disturbances in several immune-system-related pathways contribute to development of autism spectrum disorders. The report published December 4 in the open-access journal PLOS ONE powerfully supports a role for the immune function in autism by integrating analysis of autism-associated DNA sequence variations with that of markers identified in studies of families affected by autism.

"Others have talked about immune function contributions to autism, but in our study immune involvement has been identified through a completely nonbiased approach," says Vishal Saxena, PhD, of the Massachusetts General Hospital (MGH) Department of Neurology, first, corresponding and co-senior author of the PLOS ONE paper. "We let the data tell us what was most important; and most tellingly, viral infection pathways were most important in this immune-related mechanism behind autism."

Genetic studies of families including individuals with autism have indentified linkages with different locations in the genome. Since traditional interpretation methods implicate the gene closest to a marker site as the cause of a condition, those studies appeared to point to different genes affecting different families. However, Saxena's team realized that, since autism has typical symptoms and affects the same biological processes, a common molecular physiology must be affecting the different families studied. To search for genetic pathways incorporating these autism-associated sites, they developed a methodology called Linkage-ordered Gene Sets (LoGS) that analyzes all of the genes within a particular distance from marker sites and ranks them according to their distance from the marker.

Saxena's team first analyzed previously identified copy-number variants (CNVs) deletions or duplications of large DNA segments
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
2. Study finds prioritizing rather than canvassing entire plant genome may lead to improved crops
3. UC Davis researchers aid effort to sequence the complex wheat genome
4. USDA scientists and cooperators sequence the wheat genome in breakthrough for global food security
5. Bread wheats large and complex genome is revealed
6. Genome decoded: Scientists find clues to more disease-resistant watermelons
7. Short DNA strands in the genome may be key to understanding human cognition and diseases
8. Researchers decode birch tree genome sequence for the first time
9. Pear genome provides new insight into breeding improvement and evolutionary trace analysis
10. USDA funded research leads to key discoveries in the pig genome
11. Researchers sequence swine genome, discover associations that may advance animal and human health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
(Date:4/17/2014)... Cell Press journal Current Biology on April ... sex lives. The Brazilian insects, which represent four distinct ... are the first example of an animal with sex-reversed ... in several different animals, Neotrogla is the ... reversed," says Kazunori Yoshizawa from Hokkaido University in Japan. ...
(Date:4/17/2014)... process whereby the genetic information of DNA is ... which have numerous different functions in living organisms. ... during gene expression, by relating the genetic information ... manufacturing proteins. , By examining the different ... an organism at a given time, researchers can ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2In sex-reversed cave insects, females have the penises 2Rapid and accurate mRNA detection in plant tissues 2
... 2008 From the sun,s UVA rays to tobacco smoke, ... to cancer. Thanks to our body,s DNA repair mechanisms, however, ... the formation of tumours. Now, according to a new ... of the National Academy of Sciences of the USA ...
... administration will confront an array of threats and challenges ... president, says Steve Fetter, dean of the University of ... Fetter asked six experts on his faculty with deep ... steps to address key challenges. Most of ...
... CAMBRIDGE, Mass. -- MIT engineers have outfitted cells with tiny ... tumors or become building blocks for tissue engineering. Michael ... and senior author of a paper on the work that ... said he believes this is the first time anyone has ...
Cached Biology News:Repairing DNA damage: Researchers discover critical process in cancer treatment 2Advice to the new administration: UM foreign and domestic policy guide 2Advice to the new administration: UM foreign and domestic policy guide 3Advice to the new administration: UM foreign and domestic policy guide 4Advice to the new administration: UM foreign and domestic policy guide 5Advice to the new administration: UM foreign and domestic policy guide 6Advice to the new administration: UM foreign and domestic policy guide 7MIT creates tiny backpacks for cells 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 ... Almshouse Road, Warrington, Pa. , Details: The Hepatitis ... finding a cure for hepatitis B and improving the quality ... Crystal Ball on Friday, April 11 at Warrington Country Club ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Toronto, Canada (PRWEB) January 14, 2014 ... and its motives and methods in product development and ... of the industry. This mistrust, fueled by concerns about ... further fed by reports of spectacular fines to the ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Therapeutics, Inc. ("CTI") (Nasdaq and MTA: CTIC) today announced ... pixantrone for the treatment of relapsed/refractory diffuse large B-cell ... patient enrollment. The trial, referred to as the PIX-R ... pixantrone plus rituximab to a combination of gemcitabine plus ...
... 2011 Recent events in Japan have caused the ... radiation can be a cause for concern – especially ... targets rapidly proliferating cells of the body. Cells of ... tract are two such cell types. Damage to these ...
... HILL, N.C., March 18, 2011 Driving value for customers ... are many touch points between a customer and an organization, ... in order for an organization to succeed in the marketplace. ... consulting firm Best Practices, LLC., noted in this month,s special ...
Cached Biology Technology:Cell Therapeutics Initiates Pixantrone PIX-R Pivotal Trial for Treatment of Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma 2Cell Therapeutics Initiates Pixantrone PIX-R Pivotal Trial for Treatment of Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma 3Cell Therapeutics Initiates Pixantrone PIX-R Pivotal Trial for Treatment of Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma 4Existing Radiation Countermeasures Inadequate! Development of Rx100 Promises Change! 2Existing Radiation Countermeasures Inadequate! Development of Rx100 Promises Change! 3Best Practices, LLC Showcases Its Expertise in Customer Relationship Management 2
Pendrin (H-195)...
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
... polymerase is a thermostable DNA polymerase purified ... with the procedures developed by Kaledin (1,2,3) ... DNA polymerase activity from thermophilic bacteria. Amplification ... can be achieved with this enzyme. The ...
... to Cytokeratin 5 / 6 Cytokeratin ... weight, basic type of cytokeratin expressed in ... layers of stratified epithelia as well as ... cells and mesothelioma. Cytokeratin 6 (56 kD) ...
Biology Products: