Navigation Links
Combining brain imaging, genetic analysis may help identify people at early risk of Alzheimer's
Date:2/8/2011

For Immediate Release February 8, 2011 - (Toronto) A new study from the Centre for Addiction and Mental Health (CAMH) has found evidence suggesting that a variation of a specific gene may play a role in late-onset Alzheimer's, the disease which accounts for over 90% of Alzheimer's cases. This innovative study has combined genetics and brain imaging to determine who may be at risk for developing late-onset Alzheimer's disease long before symptoms appear.

The gene, which is called brain-derived neurotrophic factor (BDNF), is crucial to maintaining healthy function of the brain, primarily the brain's memory centre of the hippocampus and entorhinal cortex, and is responsible for learning and memory function. Past research has found that less BDNF is present in the memory centre of those diagnosed with Alzheimer's disease. However genetic association studies alone have not produced definite findings regarding this gene. Instead, a combination of genetics and brain imaging were used to demonstrate clear effects of this gene in the brain.

In the study published today in the Archives of General Psychiatry, a variation of the BDNF gene called val66met, was tracked and examined in healthy individuals to see what effect it had on the brain. Genotyping was used to determine which study participants carried the gene variation. Then two types of brain imaging -- high-resolution magnetic resonance imaging (MRI) cortical thickness mapping and diffusion tensor imaging (DTI) (an MRI-based technique that measures key structural connections in the brain)-- were applied to measure the physical structures of the brain in each individual. This combination of genetic screening and imaging found that BDNF val66met gene variation influenced exactly those brain structures and connections that deteriorate at the earliest phases of Alzheimer's disease.

"Our sample consisted of healthy adults who passed all cognitive testing and displayed no clinical sym
'/>"/>

Contact: Michael Torres
media@camh.net
416-595-6015
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Combining sun, sand and science in the Bahamas
2. Ecology in organic ag: Combining farming, science
3. Combining nanotubes and antibodies for breast cancer search and destroy missions
4. Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction
5. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
6. During exercise, the human brain shifts into high gear on alternative energy
7. Millisecond brain signals predict response to fast-acting antidepressant
8. Food for thought -- regulating energy supply to the brain during fasting
9. Risk and reward compete in brain
10. Brainy genes, not brawn, key to success on mussel beach
11. Brain-nourishing molecule may predict schizophrenia relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... 2014, Irvine, Calif. UC Irvine neurobiologists have found ... when transplanted into the brains of mice with the ... is published in the journal Stem Cells Research ... to work in two different mouse models. , ... dementia, is associated with accumulation of the protein amyloid-beta ...
(Date:4/15/2014)... know as early as 2020 how high sea levels ... team of researchers including Florida International University scientist Rene ... Science Foundation,s (NSF) Florida Coastal Everglades Long-Term Ecological Research ... in ecosystems from coral reefs to deserts, mountains to ... sea level rise is one of the most certain ...
(Date:4/15/2014)... UC San Diego have succeeded in visualizing the ... for growth and resistance to drought. The achievement ... determine how the hormone helps plants respond to ... continuing increase in the atmosphere,s carbon dioxide, or ... in the April 15 issue of the scientific ...
Breaking Biology News(10 mins):UCI study finds modified stem cells offer potential pathway to treat Alzheimer's disease 2Long-term predictions for Miami sea level rise could be available relatively soon 2Biologists develop nanosensors to visualize movements and distribution of plant hormone 2
... earths system of mid-ocean ridges plays a pivotal role in ... heat flow from the interior, and the chemistry of rock, ... that scientists discovered the existence of vast plumbing systems under ... spit it back out from seafloor ventsa process that brings ...
... of the most common human parasites, Toxoplasma gondii, uses a ... increase its numbers and when to remain dormant, researchers at ... The scientists report this week in Nature that they ... (ABA), with a plant herbicide. Low doses of the herbicide ...
... Association of Water Companies (NAWC) held its annual ... Bob Iacullo presented the 2007 Management Innovation Awards. ... to share innovative approaches to issues relevant to ... to United Water for the entry Senior Design ...
Cached Biology News:Quakes under Pacific floor reveal unexpected circulatory system 2Quakes under Pacific floor reveal unexpected circulatory system 3Disrupting common parasites' ability to 'talk' to each other reduces infection 2Disrupting common parasites' ability to 'talk' to each other reduces infection 3United Water, in partnership with Stevens, wins Management Innovation Award 2
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... AMSTERDAM, February 20 Elsevier announced today,that ... abstract and,citation (A&C) database, was chosen by ... in Research for Australia (ERA) initiative. , ... will assess research quality within Australia,s higher,education ...
... of the world,s most versatile and widely used chemicals. ... is commonly used as a bleach, an antiseptic and ... J. Kiely, hydrogen peroxide has eluded the best efforts ... environmentally friendly means of producing it. , "Hydrogen peroxide ...
... Safety Study in Patients with Severe Post-Operative Pain; ... and Support NDA SubmissionSYDNEY and BEDMINSTER, N.J., Feb. ... QRXPY), a clinical-stage specialty pharmaceutical company focused on ... and central nervous system (CNS) disorders, announced today ...
Cached Biology Technology:The Australian Research Council Selects Scopus for the Evaluation of the Australian Research Landscape 2The Australian Research Council Selects Scopus for the Evaluation of the Australian Research Landscape 3Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide 2Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide 3Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide 4QRxPharma Initiates Second Comparative Study for MoxDuo(TM) IR Dual-Opioid(TM) Pain Therapy 2QRxPharma Initiates Second Comparative Study for MoxDuo(TM) IR Dual-Opioid(TM) Pain Therapy 3QRxPharma Initiates Second Comparative Study for MoxDuo(TM) IR Dual-Opioid(TM) Pain Therapy 4
... (eIF4E-binding protein II) is involved in translation ... kidney. PHAS proteins bind to eIF-4E, the ... capped mRNA in vitro and in cells. ... of PHAS/eIF-4E complexes. This allows eIF-4E to ...
... 2 (VMAT2). An antibody made to the ... at ~55 kDa in postnuclear supernatants of ... wild type cells (2). Some additional bands, ... also detected and remain unaffected by the ...
... Anti-Matrix Metalloproteinase-2, Hinge Region By immunoblotting ... native protein. It reacts with free MMP-2 ... antibody buffered aqueous glycerol solution ... pH 7.4, containing 50% glycerol and 15 ...
Acetylcholinesterase from human and monkey....
Biology Products: