Navigation Links
Combining brain imaging, genetic analysis may help identify people at early risk of Alzheimer's
Date:2/8/2011

For Immediate Release February 8, 2011 - (Toronto) A new study from the Centre for Addiction and Mental Health (CAMH) has found evidence suggesting that a variation of a specific gene may play a role in late-onset Alzheimer's, the disease which accounts for over 90% of Alzheimer's cases. This innovative study has combined genetics and brain imaging to determine who may be at risk for developing late-onset Alzheimer's disease long before symptoms appear.

The gene, which is called brain-derived neurotrophic factor (BDNF), is crucial to maintaining healthy function of the brain, primarily the brain's memory centre of the hippocampus and entorhinal cortex, and is responsible for learning and memory function. Past research has found that less BDNF is present in the memory centre of those diagnosed with Alzheimer's disease. However genetic association studies alone have not produced definite findings regarding this gene. Instead, a combination of genetics and brain imaging were used to demonstrate clear effects of this gene in the brain.

In the study published today in the Archives of General Psychiatry, a variation of the BDNF gene called val66met, was tracked and examined in healthy individuals to see what effect it had on the brain. Genotyping was used to determine which study participants carried the gene variation. Then two types of brain imaging -- high-resolution magnetic resonance imaging (MRI) cortical thickness mapping and diffusion tensor imaging (DTI) (an MRI-based technique that measures key structural connections in the brain)-- were applied to measure the physical structures of the brain in each individual. This combination of genetic screening and imaging found that BDNF val66met gene variation influenced exactly those brain structures and connections that deteriorate at the earliest phases of Alzheimer's disease.

"Our sample consisted of healthy adults who passed all cognitive testing and displayed no clinical sym
'/>"/>

Contact: Michael Torres
media@camh.net
416-595-6015
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Combining sun, sand and science in the Bahamas
2. Ecology in organic ag: Combining farming, science
3. Combining nanotubes and antibodies for breast cancer search and destroy missions
4. Muscle mass in elderly boosted by combining resistance exercise and blood flow restriction
5. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
6. During exercise, the human brain shifts into high gear on alternative energy
7. Millisecond brain signals predict response to fast-acting antidepressant
8. Food for thought -- regulating energy supply to the brain during fasting
9. Risk and reward compete in brain
10. Brainy genes, not brawn, key to success on mussel beach
11. Brain-nourishing molecule may predict schizophrenia relapse
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... been raging this summer and some of the smoke from ... this image collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) ... of smoke has descended over the Great Lakes region of ... fire image from July 23, 2014 (first image feature highlighted ... drifts off southeastward. In the image, it is over ...
(Date:7/25/2014)... the International Journal of Cancer earlier this ... based on findings showing successful reduction in the risk ... of cells in the cervix. , The findings ... cells, or SCJ cells. These cells reside in the ... of cervical cancer. A research team co-led by Christopher ...
(Date:7/25/2014)... engineering at the University of Houston, has written ... organ development., "Introduction to Tissue Engineering: Applications and ... the field of artificial organ development. Metin Akay, ... UH, served as a series editor on the ... published books on the subject of growing artificial ...
Breaking Biology News(10 mins):Clearing cells to prevent cervical cancer 2University of Houston researcher publishes textbook on tissue engineering 2
... at the RIKEN SPring-8 Center in Harima, Japan have ... reductase (qNOR), a bacterial enzyme that offers clues on ... to their importance to fundamental science, the findings provide ... ozone-depleting and greenhouse gas hundreds of times more potent ...
... of alcohol found in alcoholic beverages, can more than double ... Caenorhabditis elegans , which is used frequently as a model ... find their discovery difficult to explain. "This ... UCLA professor of chemistry and biochemistry and the senior author ...
... electromagnetic Terahertz (THz) waves or T-rays - the technology behind ... in the journal Nature Photonics , say their new ... to make better medical scanning gadgets and may one day ... Star Trek. In the study, researchers from the Institute ...
Cached Biology News:New study sheds light on evolutionary origin of oxygen-based cellular respiration 2Tiny amounts of alcohol dramatically extend a worm's life, but why? 2Tiny amounts of alcohol dramatically extend a worm's life, but why? 3Tiny amounts of alcohol dramatically extend a worm's life, but why? 4T-rays technology could help develop Star Trek-style hand-held medical scanners 2T-rays technology could help develop Star Trek-style hand-held medical scanners 3
(Date:7/28/2014)... July 28, 2014 Research and Markets ... Analysis Market 2014-2018" report to their offering. ... analysis is a technique used to determine the size of ... It is crucial to analyze the size of particles as ... size analysis is performed to determine the behavior and nature ...
(Date:7/25/2014)... MA -- Trillions of bacteria live in each person,s ... help digest food and stave off harmful infections, but ... , To help shed light on the role of ... associate professor Eric Alm recently tracked fluctuations in the ... year. The findings, described in the July 25 issue ...
(Date:7/25/2014)... PA (PRWEB) July 25, 2014 The ... Call for Topics for Conferee Networking. These two-hour sessions ... interests to meet and resolve problems, discuss new techniques, ... The deadline to submit a topic for consideration is ... pittcon.org . The Conferee Networking committee will review ...
(Date:7/25/2014)... , July 25, 2014 Sinovac Biotech Ltd. (Nasdaq: ... in China , today announced that it ... ended June 30, 2014, after market close on Thursday, August ... prior to the market opening on Friday, August 15, 2014, ... p.m. China Standard Time) to review the Company,s financial results ...
Breaking Biology Technology:Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... Wisconsin governor are playing a game of one- upsmanship on pocketbook ... to up the ante after Gov. Jim Doyle announced ... ethanol. , ,Green, however, did not take that opportunity to call ... once voted for legislation to repeal the controversial law. Instead, he ...
... of the Fox Broadcasting Company 's hit television program, ... preparing to exploit a consumer market catering to aspiring pop ... products for digital video, music, DVD, and audio production, has ... develop two software products based on the show, which won ...
... Wis. - Saying former employees began to develop Bone ... that purchased Bone Care in 2005 is suing three former ... , , Genzyme Corp . filed the suit in ... , claiming that the plaintiffs applied for patents on new ...
Cached Biology Technology:Green doesnt up the ante on markup law 2American Idol spurs music software 2Genzyme sues former Bone Care employees 2Genzyme sues former Bone Care employees 3
Anti-Potassium Channel EAG-1 Immunogen: Synthetic peptide from the C-terminus of rat Kv10.1 (Accession Q63472). The immunogen sequence is identical in mouse and 14/16 residues identical in human...
WIF-1 (N-20)...
VEGF Receptor-2, phospho-specific (Tyr996)...
For the differentiation of mouse embryonic stem cells tooligodendrocytes....
Biology Products: