Navigation Links
Combinations of estrogen-mimicking chemicals found to strongly distort hormone action
Date:3/28/2013

For years, scientists have been concerned about chemicals in the environment that mimic the estrogens found in the body. In study after study, researchers have found links between these "xenoestrogens" and such problems as decreased sperm viability, ovarian dysfunction, neurodevelopmental deficits and obesity. But experimental limitations have prevented them from exploring one of the most serious questions posed by exposure to xenoestrogens: what happens when as in the real world an individual is exposed to multiple estrogen-mimicking chemicals at the same time?

Now University of Texas Medical Branch at Galveston researchers have used new techniques to study exposure to low doses of multiple xenoestrogens. And they've come to some disturbing conclusions.

Using cell cultures to test mixtures of three compounds known to affect estrogen signaling, bisphenol A (found in plastic bottles and the linings), bisphenol S (a supposedly safer replacement for bisphenol A recently found to have similar effects) and nonylphenol (a common component of industrial detergents and surfactants) the scientists determined that combinations of endocrine disruptors could have a dramatically greater effect than any one of them alone.

"We wanted to see how these persistent, ubiquitous contaminants affect estrogenic signaling when they're mixed together as they are in nature, so we set up a cell-culture system that allowed us to test their influence on signaling by estradiol, the estrogen found in adult, cycling women," said UTMB professor Cheryl Watson, senior author of a paper on the study now online in the journal Environmental Health (http://www.ehjournal.net/). "What we found is that these things gang up on estradiol and thwart its response, which is not a good thing."

Watson and her colleagues tested different mixtures of estrogen-disrupting compounds using rat pituitary cells, ce
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cats are able to navigate complex combinations of wet and dry foods to achieve a consistent intake of protein, fat and carbohydrate
2. Yale Study links common chemicals to osteoarthritis
3. Numerical study suggests subsea injection of chemicals didnt prevent oil from rising to sea surface
4. Chemicals today, drugs tomorrow: U-Ms new Center for Drug Discovery
5. Hearing the telltale sounds of dangerous chemicals
6. Hormone-mimicking chemicals cause inter-species mating
7. Production of chemicals without petroleum
8. Effect of chronic exposure to chemicals used as weapons, pesticides under study
9. Brain & Behavior Research Foundation announces spring 2013 conference & free webinars
10. Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants
11. Origins of human teamwork found in chimpanzees
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... in India over the last 30 years contributed ... growth during that time, according to a new ... Change ., "Energy access is fundamental to development: ... including education, communication, and health," says IIASA researcher ... increased energy access is widely agreed to be ...
(Date:10/17/2014)... German . ... in order to reproduce? And why are there two sexes ... latest issue of the research journal Molecular Human Reproduction ... Ramm from Bielefeld University Bielefeld has compiled this special issue ... a female to copulate with several males in quick succession ...
(Date:10/16/2014)... have a new synthesis of recent research findings to ... in the two states. , The Ecology and ... Washington: A Synthesis of the Relevant Biophysical Science and ... published by the U.S. Forest Service,s Pacific Northwest Research ... managers for a synthesis of the large body of ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2
... sea ice in the Arctic has shrunk to its ... 30 years ago, opening up the Northwest Passage ... has been historically impassable. In the mosaic image ... September 2007 by the Advanced Synthetic Aperture Radar (ASAR) ...
... 2007 American Society for Microbiology (ASM) sanofi-aventis U.S. ... M.D., Ph.D., Chief, Laboratory of Malaria and Vector ... Bethesda, Maryland. Supported by an unrestricted grant ... in antimicrobial chemotherapy. Dr. Wellems has had ...
... and volunteers who helped in the clean-up effort after ... of Spain exhibit prolonged respiratory symptoms resulting from their ... to examine the long-term effects of such exposures on ... reported in the second issue for September of the ...
Cached Biology News:Satellites witness lowest Arctic ice coverage in history 2Prolonged respiratory problems for oil spill clean-up volunteers 2Prolonged respiratory problems for oil spill clean-up volunteers 3
(Date:10/22/2014)... BOSTON , Oct. 22, 2014  Actavis ... specialty pharmaceutical company, and Rhythm, a biopharmaceutical company, today ... to acquire Rhythm,s wholly owned subsidiary, Rhythm Health, Inc., ... for the treatment of diabetic gastroparesis and other GI ... successful Phase 2 trial of relamorelin for the treatment ...
(Date:10/22/2014)... October 22, 2014 WriteResult, LLC ... – has been working with a team of researchers ... Haven Farms Community Farming Collaborative to provide electronic questionnaire ... The study, which started in May, aims to ... provides participants weekly exposure to and participation in urban ...
(Date:10/22/2014)...   Synthetic Biologics, Inc. (NYSE MKT: SYN), ... infections and diseases, announced today that the U.S. Patent ... for a composition of matter patent application that covers ... SYN-004. This is Synthetic Biologics, first allowed patent application ... to the Company,s extensive C. difficile patent ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market ... Labeling Systems, Table-top Counters) by End-user (Inpatient Pharmacy ... Trends to 2019” analyzes and studies the major ... Europe, Asia-Pacific, and the Rest of the World ... figures spread through 300 pages and in-depth TOC ...
Breaking Biology Technology:Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... SALT LAKE CITY, March 17 Axial Biotech, ... of molecular diagnostics,and motion preserving technologies, announced today ... its development of the first genetic,prognostic test for ... million tranche of its Series B financing. The ...
... Declares Preferred Stock Dividend -, SAN DIEGO, Calif., ... ) today announced that its board of directors has,declared ... of common stock,an 8.1% increase over the company,s previous ... equivalent to an annualized dividend,of $1.34 per common share., ...
... IRVINE, Calif., March 14 Masimo Corporation,(Nasdaq: MASI ), ... pulse oximetry, today announced that it is scheduled,to present at ... The Four Seasons Hotel in Las Vegas, NV on Wednesday, ... and CEO, and Mark P. de,Raad, Executive Vice President and ...
Cached Biology Technology:Axial Biotech Meets Major Scientific Milestones; Receives $6 Million Tranche of Series B Financing 2BioMed Realty Trust Announces Increase in Quarterly Common Stock Dividend 2Masimo to Present at Citi Investment Research 5th Annual Small & Mid-Cap Conference 2
... is described by end-users to be "a ... fundamentals of light microscopy and electronic imaging. ... it does not require much space and ... lab environment. The DM-BA300 combines Motic's own ...
... Overhead Drive for individual and parallel agitation ... agitation of DASGIP vessels, featuring range of ... ,Up to 16 overhead drives can be ... Systems fedbatch-pro® and cellferm-pro® for microbiology and ...
... Life Science LAS-3000 imaging system combines ... simplified user interface, providing significantly improved ... of modularities. The system is especially ... perfect standard system for Western blotting ...
Capture faint-light images without losing sensitivity or resolution. With its brand new hardware and interface design, the LAS-1000plus turns sample imaging into a simple process....
Biology Products: