Navigation Links
Combinations of estrogen-mimicking chemicals found to strongly distort hormone action
Date:3/28/2013

For years, scientists have been concerned about chemicals in the environment that mimic the estrogens found in the body. In study after study, researchers have found links between these "xenoestrogens" and such problems as decreased sperm viability, ovarian dysfunction, neurodevelopmental deficits and obesity. But experimental limitations have prevented them from exploring one of the most serious questions posed by exposure to xenoestrogens: what happens when as in the real world an individual is exposed to multiple estrogen-mimicking chemicals at the same time?

Now University of Texas Medical Branch at Galveston researchers have used new techniques to study exposure to low doses of multiple xenoestrogens. And they've come to some disturbing conclusions.

Using cell cultures to test mixtures of three compounds known to affect estrogen signaling, bisphenol A (found in plastic bottles and the linings), bisphenol S (a supposedly safer replacement for bisphenol A recently found to have similar effects) and nonylphenol (a common component of industrial detergents and surfactants) the scientists determined that combinations of endocrine disruptors could have a dramatically greater effect than any one of them alone.

"We wanted to see how these persistent, ubiquitous contaminants affect estrogenic signaling when they're mixed together as they are in nature, so we set up a cell-culture system that allowed us to test their influence on signaling by estradiol, the estrogen found in adult, cycling women," said UTMB professor Cheryl Watson, senior author of a paper on the study now online in the journal Environmental Health (http://www.ehjournal.net/). "What we found is that these things gang up on estradiol and thwart its response, which is not a good thing."

Watson and her colleagues tested different mixtures of estrogen-disrupting compounds using rat pituitary cells, ce
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cats are able to navigate complex combinations of wet and dry foods to achieve a consistent intake of protein, fat and carbohydrate
2. Yale Study links common chemicals to osteoarthritis
3. Numerical study suggests subsea injection of chemicals didnt prevent oil from rising to sea surface
4. Chemicals today, drugs tomorrow: U-Ms new Center for Drug Discovery
5. Hearing the telltale sounds of dangerous chemicals
6. Hormone-mimicking chemicals cause inter-species mating
7. Production of chemicals without petroleum
8. Effect of chronic exposure to chemicals used as weapons, pesticides under study
9. Brain & Behavior Research Foundation announces spring 2013 conference & free webinars
10. Brain & Behavior Research Foundation awards nearly $4 million in new NARSAD grants
11. Origins of human teamwork found in chimpanzees
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... which have devastated algal forests in the eastern Mediterranean ... basin if their distribution continues to expand as the ... an international team of researchers led by Dr Adriana ... the Mediterranean Institute for Advanced Studies in Spain, is ... of the team surveyed more than 1000 kilometres of ...
(Date:9/18/2014)... fish world, are the ideal animal in which to ... from the ocean into tens of thousands of freshwater ... their skeleton to adapt to the new environment. , ... now have turned up one of the genes that ... in that gene,s regulation in a freshwater population is ...
(Date:9/17/2014)... to reproductive technologies, the justice and well-being of ... to identify key issues, articulate their values and ... most defensible ways forward. But what are the ... The Hastings Center and the Presidential Commission for ... to publish a series of essays to highlight ...
Breaking Biology News(10 mins):Tropical fish a threat to Mediterranean Sea ecosystems 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3Why bioethics literacy matters 2Why bioethics literacy matters 3
... chronic heart failure affecting 5.4 million people and 690,000 ... disease progression are needed. Developing pharmacological approaches for regenerating ... the focus of a lecture Nov. 27 at the ... and director of the Muscle Development and Regeneration Program ...
... California, Riverside has received three grants from the U.S. ... records who demonstrate financial need and plan to pursue ... need. Called " Graduate Assistance in Areas of ... fellowships to graduate students who are U.S. citizens or ...
... schizophrenia have found that irregular sleep patterns and desynchronised ... disease,s symptoms. The findings, published in the journal ... a cause and not just a consequence of the ... sleep and schizophrenia prompted the research team, led by ...
Cached Biology News:Regenerating heart tissue topic of UH lecture Nov. 27 2UC Riverside receives 3 grants to assist graduate students in pursuing doctoral degrees 2Could poor sleep contribute to symptoms of schizophrenia? 2
(Date:9/18/2014)... Research and Markets has ... Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on ... The report provides a basic overview ... industry chain structure. The N-acetylcysteine market analysis is ...
(Date:9/18/2014)... 2014 Research and Markets has ... (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends ... The global companion diagnostics market is ... 2014 to 2019. Factors such as rising need for ... diagnostics by the pharmaceutical industry, support from regulatory authorities, ...
(Date:9/18/2014)... ST. LOUIS , Sept. 18, 2014  U.S. ... portfolio by signing an exclusive license for technology developed ... to control gene expression in plants, including for applications ... species. The technology was developed under ... science officer at Kultevat and former president of the ...
(Date:9/18/2014)... 2014  Neogen Corporation (Nasdaq: NEOG ) ... agreement with Merck Animal Health to market Neogen,s Igenity ... Igenity Dairy Heifer Program consists of genomic tests that ... potential of replacement dairy heifers. The genomic tests can ... is an excellent tool in the decision-making process for ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Kultevat obtains license of gene switch technology 2Merck Animal Health to market Neogen's dairy genomic program 2
... the ... Madison, Wis. - First came the virus. Then came the ... to stay one step ahead of the computer security engineers and vice ... Jha , an associate professor of computer science at the University ...
... paraphrase Santayana , managers who do not learn from ... Enron was a colossal failure in corporate governance. , ,For ... reformers, Ken Lay served as CEO and Chairman of the ... stock, earned consulting fees working on Enron projects, and had ...
... series of articles on developing start-up companies in the technology ... - You've started your new company, named it, and ... still need additional funding, what other choices do you have? ... consider. , ,Most of us recognize that we must ...
Cached Biology Technology:UW computer scientists fighting computer virus "Cold War" 2Enron's dilemma: A corporate governance nightmare 2Enron's dilemma: A corporate governance nightmare 3Enron's dilemma: A corporate governance nightmare 4Early Stage: Step 11 - Other forms of finance 2Early Stage: Step 11 - Other forms of finance 3Early Stage: Step 11 - Other forms of finance 4
HP 1 alpha Immunogen: Synthetic peptide between amino acids 1-100 of the human HP 1 alpha protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... subcloning of gene in baculoviral expression ... and plaque purification of ten clones, ... for one clone, protein expression and ... culture. Expected yield and timeline: 1-4 ...
... Custom Synthesis Service provides you ... to knockdown any gene. We ... base pairs with terminal dT ... other lengths of your choice. ...
EDG-1 Western blot control Source: Cell Lysate Application: Western Blotting Control...
Biology Products: