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Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
Date:11/26/2012

s of brain cells, but also to develop a medication that has a positive impact on cell regeneration.

The used components of the Cyclosporine and FK506 (tacrolimus)-series have been utilized in a chemically slightly altered form as immunosuppressant medications for a long time. Both suppress the cellular immune defenses. This effect is necessary in conjunction with organ transplants, but otherwise problematic for the organism. The specific combination of the two substances amplifies the protective effect on the nerve cells thanks to different but synergistic efficacy mechanisms. The impact on the immune defense is reduced at the same time, which results in fewer side effects. Both of these achievements were corroborated by experiments. An application for a patent protecting this new class of active ingredients has now been filed. Ascenion GmbH and Max Planck Innovation both attend the project as utilization partners of the DZNE and of the Max Planck Society.


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Contact: Dirk Frger
dirk.foerger@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert  

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