Navigation Links
Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
Date:11/26/2012

Bonn/Magdeburg/Halle, 26/11/2012. A new substance class for the treatment of multiple sclerosis and other neurodegenerative diseases now promises increased efficacy paired with fewer side effects. To achieve this, a team of scientists under the leadership of Prof. Gunter Fischer (Max Planck Research Unit for Enzymology of Protein Folding, Halle/Saale, Germany) and Dr. Frank Striggow (German Center for Neurodegenerative Diseases (DZNE)) have combined two already approved pharmaceutical substances with each other using a chemical linker structure. The objectives of this combination are to ensure maximum brain cell protection on the one hand and the suppression of unwanted side effects on the other. The new class of substances has now been registered with the European Patent Office as the DZNE's first patent in the form of a joint patent application with the Max Planck Research Unit. "The patent approval process can take several years. During this phase we are planning to conclude the pre-clinical development. It is our aim to start with clinical research and development at the earliest possible time. Overall, we have identified substantial therapeutic potential as far as chronic and age-related neurodegenerative diseases are concerned," comments Dr. Frank Striggow.

Multiple sclerosis is an inflammatory disease that affects the central nervous system. It destroys the insulation of the nerve cell signaling system, the myelin sheaths of the neural axons. The consequence of this process is the malfunction of signaling and finally cell death resulting in permanent neurological problems. The cause of multiple sclerosis is that the body itself attacks the cellular components of the myelin sheaths, the oligodendrocytes. Hence, the team of scientists under the direction of Prof. Gunter Fischer and Dr. Frank Striggow embarked on a search for intervention options that could protect brain cells from these attacks. The goal was not only to prevent the damage and los
'/>"/>

Contact: Dirk Frger
dirk.foerger@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New study finds a protein combination is best to consume post-workout for building muscle
2. New line of approach for combination therapy against melanoma
3. Insecticide resistance caused by recombination of 2 genes
4. Hormone combination effective and safe for treating obesity in mice
5. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
6. Tokai Pharmaceuticals galeterone well-tolerated in patients with advanced prostate cancer
7. Fish show autism-like gene expression in water with psychoactive pharmaceuticals
8. AcelRx Pharmaceuticals Receives First U.S. Patent for Small-Volume Oral Transmucosal Dosage Forms
9. Conatus Pharmaceuticals Appoints Mark F. Morris as Head of Biostatistics
10. Strip-till improves soybean yield
11. ORNL process improves catalytic rate of enzymes by 3,000 percent
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combination of two pharmaceuticals proves effective in the treatment of multiple sclerosis
(Date:7/30/2014)... A team of biologists, led by Clemson University associate ... marine pest that will pave the way for novel ... bio-adhesives for medical and industrial applications. , The team,s ... examined the last larval stage of barnacles that attaches ... natural, possibly polymeric material that acts as an underwater ...
(Date:7/30/2014)... Press Limited today announced an across-the-board increase in ... The 2013 InCites Journal Citation Reports (Thomson Reuters, ... Biochemical Journal , Essays in Biochemistry , ... Reports all received increases in their Impact ... Society and published by Portland Press Limited. , ...
(Date:7/30/2014)... A professor from Wayne State University,s College of ... National Science Foundation for the project, "Nanoparticle-directed synthesis ... National Science Foundation, nanotechnology is the creation and ... novel properties and functions. A major bottleneck in ... methods that connect different functional materials into one ...
Breaking Biology News(10 mins):Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2Across-the-board Impact Factor increases for Portland Press Limited 2NSF grant to Wayne State supports new concept for manufacturing nanoscale devices 2
... and statistically significant improvements in clinical measures of ... the Etiology, Pathogenesis and Treatment of Parkinson's Disease ... positive interim results in patients with Parkinson's disease. ... statistically significant improvement in motor function on the ...
... discovered how a small molecule of RNA called microRNA ?a ... a key protein involved in the early development of heart ... the journal Nature, may aid scientists in their understanding of ... a heart cell, as well as offer researchers a way ...
... Paxinos and Dr Yuri Koutcherov of the Spinal Injuries ... Institute have been awarded ~$200,000 by the Christopher Reeve ... the rat spinal cord over the next two years. ... visit to Australia in 2003 and was impressed with ...
Cached Biology News:Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 2Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 3Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 4Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 5Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease 6MicroRNA tweaks protein that controls early heart development 2MicroRNA tweaks protein that controls early heart development 33D Atlas Will Help Navigate The Spinal Cord 2
(Date:7/30/2014)...  Orexigen Therapeutics, Inc. (Nasdaq: OREX ) ... of Outstanding Issues (LOI) from the European Medicines Agency,s ... the NB32 Marketing Authorization Application (MAA). NB32 (naltrexone sustained ... candidate being evaluated for weight loss. The ... were adequately addressed by the Company based in part ...
(Date:7/30/2014)... PARK, Md. , July 30, 2014 /PRNewswire-USNewswire/ ... biological components to interrogate biology, but such devices ... biology. As such, researchers have ... for in vitro metabolic engineering to ... on a chip. New devices are envisioned to ...
(Date:7/30/2014)... July 30, 2014  AtheroNova Inc. (OTCBB: AHRO), ... development of compounds to safely regress atherosclerotic plaque ... that its partner, CardioNova, has accomplished first dosing ... with AtheroNova,s lead compound, AHRO-001.  This Phase 1b ... Phase 1 safety trial completed in February 2014, ...
(Date:7/30/2014)... NCERC at Southern Illinois University Edwardsville ... on corn stover pretreatment methods at a U.S. ... D.C. , “Arun’s selection for presentation at ... to the success of our postdoctoral fellowship program,” ... foresight and vision of SIUE and the Illinois ...
Breaking Biology Technology:Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 2AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 3AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 4NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 2NCERC at SIUE Researcher Takes Stage at Department of Energy Conference 3
... Calif., March 30 TorreyPines Therapeutics, Inc. (Nasdaq: ... District Court of the Southern District of New York ... of Axonyx Inc. ("Axonyx") against Axonyx and several of ... in 2006. The plaintiffs alleged that the defendants made ...
... March 30 BioMedical Enterprises, Inc. (BME), a rapidly ... of orthopaedic memory metal implants, announced today that it ... Sales and Marketing. BME specializes in nitinol implants ... ends together to promote bone union. The ...
... Stem Cell Trial to Show Dose-related Significant Improvement in ... Amorcyte, Inc. (Amorcyte) today announced data from its ... product for the treatment of damaged heart muscle following ... between cell dose and biologic effect. This is the ...
Cached Biology Technology:Stockholder Suits Related to TorreyPines Therapeutics, Inc. Dismissed 2BioMedical Enterprises, Inc. (BME) Announces the Appointment of Keith M. Peeples as Vice President, Sales and Marketing 2Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session 2Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session 3Amorcyte Reports Phase I Results of AMR-001 to Improve Recovery From Severe Heart Attack at ACC Annual Scientific Session 4
GFX PCR DNA,Gel Band Purif,100, 1 EA. Category: Nucleotide Sample Handling....
Full service including gene cloning, protien expression and purification of 1 liter culture....
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
Protein 3D structure prediction, via threading. Easy to use....
Biology Products: