Navigation Links
Combination of cell transplantation and gene therapy for Alzheimer's disease
Date:12/24/2013

In a recent study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), Prof. Feng Li and team from Zhongshan School of Medicine, Sun Yat-sen University in China, synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloid beta protein (Aβ) production, and introduced it into the pSilenCircle vector to construct a short hairpin (shRNA) expression plasmid against the BACE1 gene. Researhcers transfected this vector into C17.2 neural stem cells and primary neural stem cells, resulting in downregulation of the BACE1 gene, which in turn induced a considerable reduction in reducing Aβ protein production. This technique combining cell transplantation and gene therapy will open up novel therapeutic avenues for Alzheimer's disease, particularly because it can be used to simultaneously target several pathogenetic changes in the disease.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. The economically valuable sweet-gum trees: Taxonomy and 9 new combinations
2. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
3. Smoking + asthma + pregnant = a dangerous combination
4. Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs
5. Combinations of estrogen-mimicking chemicals found to strongly distort hormone action
6. Pesticide combination affects bees ability to learn
7. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
8. Experimental drug combination selectively destroys lymphoma cells
9. FASEB SRC announces conference registration open for: Genetic Recombination & Genome Rearrangements
10. TGen, Scottsdale Healthcare study shows drug combination extends pancreatic cancer patient survival
11. Cats are able to navigate complex combinations of wet and dry foods to achieve a consistent intake of protein, fat and carbohydrate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combination of cell transplantation and gene therapy for Alzheimer's disease
(Date:6/22/2016)... June 22, 2016  The American College of Medical Genetics ... Executive Magazine as one of the fastest-growing trade shows ... at the Bellagio in Las Vegas . ... percentage of growth in each of the following categories: net ... and number of attendees. The 2015 ACMG Annual Meeting was ...
(Date:6/21/2016)... British Columbia , June 21, 2016 /PRNewswire/ ... appointed to the new role of principal product ... been named the director of customer development. Both ... NuData,s chief technical officer. The moves reflect NuData,s ... teams in response to high customer demand and ...
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... ... December 07, 2016 , ... ... to an early access program for SmartBiome -- a novel metagenomic deep-sequencing ... simultaneous specific enrichment and detection of hundreds of different genes. The selective ...
(Date:12/6/2016)... Laurel, NJ (PRWEB) , ... December 06, 2016 ... ... white paper on December 1, 2016 asking the Federal Drug Administration (FDA) to ... the study of OA, OARSI is concerned about the growing population of OA ...
(Date:12/6/2016)... -- According to a new market research report "Microfluidics ... Application (Genomics, Proteomics, Capillary Electrophoresis, POC, Clinical, Environmental, Drug Delivery) - ... projected to reach USD 8.78 Billion by 2021 from USD 3.65 ... period (2016 to 2021). Continue Reading ... ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... development of precision treatments for neurodegenerative diseases, today announced the validated monoclonal ... the direct neurotoxic effect of prion-like forms of Amyloid beta (Aß) in ...
Breaking Biology Technology: