Navigation Links
Combination of cell transplantation and gene therapy for Alzheimer's disease
Date:12/24/2013

In a recent study published in the Neural Regeneration Research (Vol. 8, No. 33, 2013), Prof. Feng Li and team from Zhongshan School of Medicine, Sun Yat-sen University in China, synthesized a 19-nt oligonucleotide targeting BACE1, the key enzyme in amyloid beta protein (Aβ) production, and introduced it into the pSilenCircle vector to construct a short hairpin (shRNA) expression plasmid against the BACE1 gene. Researhcers transfected this vector into C17.2 neural stem cells and primary neural stem cells, resulting in downregulation of the BACE1 gene, which in turn induced a considerable reduction in reducing Aβ protein production. This technique combining cell transplantation and gene therapy will open up novel therapeutic avenues for Alzheimer's disease, particularly because it can be used to simultaneously target several pathogenetic changes in the disease.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. The economically valuable sweet-gum trees: Taxonomy and 9 new combinations
2. Women prescribed combination HRT should use caution when taking apigenin supplement, MU study finds
3. Smoking + asthma + pregnant = a dangerous combination
4. Drug design success propels efforts to fight HIV with a combination of 2 FDA-approved drugs
5. Combinations of estrogen-mimicking chemicals found to strongly distort hormone action
6. Pesticide combination affects bees ability to learn
7. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
8. Experimental drug combination selectively destroys lymphoma cells
9. FASEB SRC announces conference registration open for: Genetic Recombination & Genome Rearrangements
10. TGen, Scottsdale Healthcare study shows drug combination extends pancreatic cancer patient survival
11. Cats are able to navigate complex combinations of wet and dry foods to achieve a consistent intake of protein, fat and carbohydrate
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Combination of cell transplantation and gene therapy for Alzheimer's disease
(Date:8/21/2014)... BLOOMINGTON, Ind. -- A new study of American ... partner, men have the highest orgasm rates. On ... time, with their sexual orientation making little difference. ... On average, women experience orgasm 62.9 percent of ... -- and this pattern varies with women,s sexual ...
(Date:8/21/2014)... unknown process for harvesting energy and producing oxygen from ... University scientist has discovered. The discovery lays the foundation ... energy from the Sun, and understanding dense blooms like ... worldwide. A paper describing the discovery will be published ... journal Science on 21 August 2014. , ...
(Date:8/21/2014)... to dandruff, eczema and other itchy, flaky maladies in ... reachesincluding Hawaiian coral reefs and the extreme environments of ... in the scientific journal PLOS Pathogens considers ... the genus Malassezia in light of new ... the world. , University of Hawai,i at Mānoa scientist ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... Goldstein checks his lobster traps in New Hampshire,s Great ... crustaceans to sell. Instead, the University of New Hampshire ... tracking their migrations year-round. Goldstein has ... Great Bay throughout the past two years. This research, ...
... scientists from the California Institute of Technology (Caltech) have ... numbers of cells moving en masse during some of ... findings not only provide insight into this stage of ... a living organism choreographs the motions of thousands of ...
... start or extend a family should avoid using the ... already recommend that women who are pregnant should stop ... knowledge that cholesterol is essential for normal fetal development. ... congenital anomalies in children of pregnant women using statins ...
Cached Biology News:UNH researchers track lobster migrations to improve population estimates 2UNH researchers track lobster migrations to improve population estimates 3Caltech researchers get first look at how groups of cells coordinate their movements 2Caltech researchers get first look at how groups of cells coordinate their movements 3Statin warning for pregnant women 2
(Date:8/21/2014)... scientists has observed tiny quantum vortices in cold droplets ... Science that the exotic vortices arrange themselves ... the first time that the quantum vortices, which have ... known as superfluid helium, have been detected in nanodroplets. ... Vilesov of the University of Southern California, one of ...
(Date:8/21/2014)... 21, 2014 ... announced the addition of the  "Global Hormone ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,Hormone ... is a means of replacing hormones that ... body. This type of therapy is usually ...
(Date:8/21/2014)... SPRING, N.Y. , Aug. 21, 2014 /PRNewswire/ ... the launch of their Nutraceutical "TELO-20 for Dogs" ... and only Telomere-lengthening supplement in the world for ... ends of every chromosome in the body. A ... world,s leading experts in Telomere Science and Aging, ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources Group ... Brazil and Mexico ... of several newly approved agents, the anticipated label ... and the launch of emerging biologics will substantially ... particular, the emerging IL-5 inhibitors will introduce a ...
Breaking Biology Technology:Scientists observe quantum vortices in cold helium droplets 2Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
... a wide range of biological samples , using disposable probes ... , The TissueRuptor system enables rapid, ... plant tissue. , , ... Disposable probes to help eliminate cross-contamination , ...
... , ... collection of the sample, leading to changes in the gene,expression ... real-time RT-PCR and microarray analysis,it is important to stabilize the ... of,high-quality RNA from animal tissues, bacteria, and human blood and ...
... An air impaction microbial assessment ... compressed air system , ... , Manufacturers of medical ... various applications. Applications include injection molding, operation of conveyor belts, and/or aseptic ...
Cached Biology Technology:TissueRuptor System 2TissueRuptor System 3Successful stabilization of gene expression profiles 2Successful stabilization of gene expression profiles 3Testing Compressed Air Lines for Microbiological Contamination 2Testing Compressed Air Lines for Microbiological Contamination 3Testing Compressed Air Lines for Microbiological Contamination 4Testing Compressed Air Lines for Microbiological Contamination 5Testing Compressed Air Lines for Microbiological Contamination 6
...
Collected from sexually matured, mixed breed, mixed sex guinea pigs....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
DTT, 25g...
Biology Products: