Navigation Links
Columbia's 2013 Horwitz Prize awarded for discoveries that could lead to new Alzheimer's treatments
Date:12/5/2013

gator, Howard Hughes Medical Institute.

In 1971, Dr. O'Keefe discovered specific cells in the hippocampus that record location. These place cells, as they are called, register the locations of specific landmarks, such as the laboratory, or the corner deli. While recording the firing of neurons in rats as they moved from one location to another, he found that each location was logged by its own unique set of nerve cells in the CA1 region of the hippocampus, suggesting that the cells form a virtual map of the animal's location. The firing location of each cell was stable over time, and moving the animal to another location caused it to form a new map, using some of the same cells, in addition to new ones. When the animal was returned to its original location, it replayed the initial map that it had formed.

In 1996, Drs. Edvard Moser and May-Britt Moser, longtime collaborators who are married to each other, worked with Dr. O'Keefe, who became their mentor, to learn how to record the activity of cells in the hippocampus.

Nearly a decade later, the Moser team discovered cells, in the entorhinal cortex region in the brains of rats, which function as a navigation system. These grid cells, as they are called, are responsible for the animals' knowing where they are, where they have been, and where they are going; they are constantly working to create a map of the outside world. Constructed in the nervous system from tactile, visual, and other sensory input, grid cells have provided fundamental insights into how spatial location and memory are computed in the brain. The mapping information flows from the entorhinal cortex to the hippocampus and then back, and scientists are now working to understand how the grid cells inform place cells, and vice versa.

Because the entorhinal cortex, which contains the grid cell navigation system, is often damaged in the early stages of Alzheimer's disease, the work by the Mosers and Dr. O'Keefe on how memo
'/>"/>

Contact: Elizabeth Streich
eas2125@cumc.columbia.edu
212-305-3689
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brandeis scientists win prestigious prize for circadian rhythms research
2. Stanford and MIT scientists win Perl-UNC Neuroscience prize
3. March of Dimes awards $250,000 prize to 2 scientists who pioneered advances in skin disorders
4. The Brain Prize 2012 is presented May 9th
5. UCSF pair win Gruber Foundation Neuroscience prize
6. Mason environmentalist awarded Blue Planet Prize for lifetime achievement in conservation
7. Reaxys announces winners of the 2012 Reaxys Ph.D. Prize
8. $500,000 Gruber Foundation Genetics Prize goes to Philadelphia scientist
9. Dr. Douglas Wallace to receive Gruber Foundation 2012 Genetics Prize
10. University of Tennessee professor wins worlds top prize for ecology, environmental science
11. World Food Prize winner among speakers at agronomy, crop and soil science societies meetings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Columbia's 2013 Horwitz Prize awarded for discoveries that could lead to new Alzheimer's treatments
(Date:7/24/2014)... Environmental cleanup experts gathered at NJIT this week for ... by the U.S. Environmental Protection Agency (EPA) to dredge ... Passaic River. , The EPA has called the plan, ... sediments and capping sections of the riverbed, one of ... material would be dredged and disposed off-site. , "We ...
(Date:7/24/2014)... For years, researchers and patients have hoped that embryonic ... in the bodycould provide insight into numerous diseases perhaps ... been hampered by the inability to transfer research and ... in part because human ESCs are "primed" and slightly ... Theunissen, Benjamin Powell, and Haoyi Wang, who are scientists ...
(Date:7/24/2014)... the primordial soup in which life arose have been maintained ... of East Anglia. , Research published today in the ... yeast and very likely also in animals still perform ancient ... life some four billion years ago. , The primordial ... ocean as a result of the combination of metals, gases ...
Breaking Biology News(10 mins):Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2
... research in France on patients diagnosed with cryptococcosis ... patients infected by HIV and who are profoundly ... 5 2007 in PLoS Medicine, uncovers parameters associated ... sex and the infecting serotype. In light of ...
... In a venture once thought to lie outside the ... Beth Israel Deaconess Medical Center have captured and sequenced ... Tyrannosaurus rex. The protein fragments—seven in all—appear to most ... present day chickens, lending support to a recent and ...
... international consortium of researchers has published the genome sequence ... the chimpanzee and human genomes. Published April 13 in ... reveals that the three primate species share about 93 ... among their genes. , In its paper, the Rhesus ...
Cached Biology News:New recommendations against a major opportunistic infection -- cryptococcosis 2New recommendations against a major opportunistic infection -- cryptococcosis 3Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex 2Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex 3Protein fragments sequenced in 68 million-year-old Tyrannosaurus rex 4Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps 2Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps 3
(Date:7/24/2014)... OAK RIDGE, Tenn., July 24, 2014 -- A novel ... at the Department of Energy,s Oak Ridge National Laboratory ... known for its unusual physical and electrochemical properties. ... examined how oxygen affects the surface of a perovskite ... electronic behavior. The new avenue to understand surface behavior ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
(Date:7/24/2014)... DUBLIN , July 24, 2014 ... the "Global Cell Culture Market 2014-2018" report ... Cell culture is the in vitro ... such as research, cell studies, and biopharmaceutical production. Cell ... vaccine production. Cell culture instruments and cell culture consumables ...
(Date:7/24/2014)... Three companies from the angelMD network ... C Competition. Out of 700 competition entrants, Chiron Health, ... semi-final round. In this round twenty teams are invited ... with mentoring from thought-leaders and medical entrepreneurs from all ... angelMD commitment to the Livestrong vision around the Big ...
Breaking Biology Technology:ORNL study reveals new characteristics of complex oxide surfaces 2Nano-sized chip 'sniffs out' explosives far better than trained dogs 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 23 angelMD Startups Make Livestrong Big C Semi-finals 2
... nothing in record numbers. , ,In 2003, an estimated 5 ... as LiveJournal , Movable Type , and Weblogger ... a New Year's resolution. , ,A November study of eight ... 20 percent of all blogs (short for "Web logs") are abandoned ...
... cursed) Sarbanes-Oxley Act of 2002 (Sarbox), many publicly ... financial recording and accounting practices and updated their ... whether privately held companies and non-profits should be ... public companies. Are taking these kinds of measures ...
... , a provider of business solutions that connect ... announced today that Hance Company of Plymouth, Minn., ... solution for integration directly with Hance's Ezone parts ... , ,Under the agreement, ARI will host ...
Cached Biology Technology:Who Gives a Blog? 2Sarbanes-Oxley for the Rest of Us 2Sarbanes-Oxley for the Rest of Us 3Sarbanes-Oxley for the Rest of Us 4
... Useful as a positive control for ... to chromatin in vivo is a crucial ... extent of crosslinking is probably the most ... subsequent immunoprecipitation step should be taken into ...
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
Rab GDP dissociation inhibitor beta...
Biology Products: