Navigation Links
Columbia's 2013 Horwitz Prize awarded for discoveries that could lead to new Alzheimer's treatments
Date:12/5/2013

gator, Howard Hughes Medical Institute.

In 1971, Dr. O'Keefe discovered specific cells in the hippocampus that record location. These place cells, as they are called, register the locations of specific landmarks, such as the laboratory, or the corner deli. While recording the firing of neurons in rats as they moved from one location to another, he found that each location was logged by its own unique set of nerve cells in the CA1 region of the hippocampus, suggesting that the cells form a virtual map of the animal's location. The firing location of each cell was stable over time, and moving the animal to another location caused it to form a new map, using some of the same cells, in addition to new ones. When the animal was returned to its original location, it replayed the initial map that it had formed.

In 1996, Drs. Edvard Moser and May-Britt Moser, longtime collaborators who are married to each other, worked with Dr. O'Keefe, who became their mentor, to learn how to record the activity of cells in the hippocampus.

Nearly a decade later, the Moser team discovered cells, in the entorhinal cortex region in the brains of rats, which function as a navigation system. These grid cells, as they are called, are responsible for the animals' knowing where they are, where they have been, and where they are going; they are constantly working to create a map of the outside world. Constructed in the nervous system from tactile, visual, and other sensory input, grid cells have provided fundamental insights into how spatial location and memory are computed in the brain. The mapping information flows from the entorhinal cortex to the hippocampus and then back, and scientists are now working to understand how the grid cells inform place cells, and vice versa.

Because the entorhinal cortex, which contains the grid cell navigation system, is often damaged in the early stages of Alzheimer's disease, the work by the Mosers and Dr. O'Keefe on how memo
'/>"/>

Contact: Elizabeth Streich
eas2125@cumc.columbia.edu
212-305-3689
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brandeis scientists win prestigious prize for circadian rhythms research
2. Stanford and MIT scientists win Perl-UNC Neuroscience prize
3. March of Dimes awards $250,000 prize to 2 scientists who pioneered advances in skin disorders
4. The Brain Prize 2012 is presented May 9th
5. UCSF pair win Gruber Foundation Neuroscience prize
6. Mason environmentalist awarded Blue Planet Prize for lifetime achievement in conservation
7. Reaxys announces winners of the 2012 Reaxys Ph.D. Prize
8. $500,000 Gruber Foundation Genetics Prize goes to Philadelphia scientist
9. Dr. Douglas Wallace to receive Gruber Foundation 2012 Genetics Prize
10. University of Tennessee professor wins worlds top prize for ecology, environmental science
11. World Food Prize winner among speakers at agronomy, crop and soil science societies meetings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Columbia's 2013 Horwitz Prize awarded for discoveries that could lead to new Alzheimer's treatments
(Date:3/31/2015)... NEW YORK , March 31, 2015  Elephant ... the "Company"), a global provider of Software Defined Network ... solutions, today announced total revenue of approximately $20.4 million ... to a restated $19.5 million for the year ended ... of calendar 2014, the Company had completed its multi-year ...
(Date:3/30/2015)... 26, 2015 Research and Markets ( ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... the Global Gesture Recognition market in Automotive Sector to ... 2013-2018. Gesture recognition is the ability of ... of an individual. Gesture recognition technology can be 2D-based ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... a key source of water for millions of people in ... climate changes as expected and future water usage is not ... of Oceanography, UC San Diego. Without Lake ... no buffer to sustain the population of the Southwest through ...
... Feb. 11 Most fashion consumers consider,custom-made jeans ... lottery,winners. But Intellifit, a leader in proprietary apparel ... perception., This week, the company will begin ... company retail store outside of Philadelphia. Using Intellifit,technology, ...
... the Moores Cancer Center at University of California, San Diego ... were treated with a gene therapy protocol began making antibodies ... be published on line the week of February 11-15 in ... of Science. Researchers led by Thomas J. Kipps, M.D., ...
Cached Biology News:Lake Mead could be dry by 2021 2Lake Mead could be dry by 2021 3Intellifit(R) Offers Custom-Made Jeans with a High-Tech Twist 2Gene therapy protocol at UCSD activates immune system in patients with leukemia 2
(Date:5/1/2015)... OncoTAb, Inc., a University ... announced that Pinku Mukherjee, Ph.D. has received the ... Governors’ highest faculty honor. Mukherjee received the award, which ... her innovative research and development of cancer diagnostics and ... crowning moment in my scientific career,” said Mukherjee, OncoTAb ...
(Date:5/1/2015)... , May 1, 2015 Pfenex ... engaged in the development of biosimilar therapeutics including ... today that its first quarter 2015 financial results ... before the open of market. At 8:30 am Eastern ... to discuss the financial results and provide a ...
(Date:5/1/2015)... 1, 2015 A new report ... drugs will reach $22.4bn in 2019. That revenue forecast ... and Market Prospects 2015-2025 ,  published in ... is to provide forecasts and qualitative analyses of the ... and consultancy in London, UK . ...
(Date:5/1/2015)... May 1, 2015 Albany Molecular Research Inc. ... S. Marth , AMRI,s President and Chief Executive Officer, ... 2015 Health Care Conference on Wednesday, May 13, 2015 ... webcast of the presentation can be accessed at AMRI,s ... The webcast will be archived for 90 days ...
Breaking Biology Technology:OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2
... New Launches Should Contribute Significantly in Second Half, ... PRX ) today announced results for the,second quarter ended ... For the second quarter ended June 28, 2008, Par ... $20.1 million, or $0.60 per diluted,share. This is compared with ...
... ITMN ) today announced that Daniel G. Welch, ... Canaccord Adams 28th Annual,Global Growth Conference in Boston on ... access a live audio webcast of the presentation, investors ... relations page of InterMune,s,corporate website at http://www.intermune.com . ...
... YORK, Aug. 7 Microbes, Inc. today announced that ... all of its outstanding,Class B Common Stock Purchase Warrants, ... 2 until 12:00 midnight, New York City time, on,Friday, ... at 12:00,midnight, New York City time, on August 7, ...
Cached Biology Technology:Par Pharmaceutical Reports Second Quarter 2008 Results 2Par Pharmaceutical Reports Second Quarter 2008 Results 3Par Pharmaceutical Reports Second Quarter 2008 Results 4Par Pharmaceutical Reports Second Quarter 2008 Results 5Par Pharmaceutical Reports Second Quarter 2008 Results 6Par Pharmaceutical Reports Second Quarter 2008 Results 7Par Pharmaceutical Reports Second Quarter 2008 Results 8