Navigation Links
Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
Date:10/3/2007

ve negative consequences, e.g. a cell could join two different chromosomes together.

The second puzzle arose following discovery of how DNA copies itself. The process cannot copy the very ends of the chromosomes. So if the DNA is copied repeatedly (as in development, when DNA of one cell is copied in all subsequent cells) the chromosome eventually shortens so much that the cells are no longer viable.

Researchers surmised that something unusual was occurring at the ends of the chromosomes, known as telomeres.

Using animal models developed by Dr. Gall, Dr. Blackburn, then a research fellow in his lab at Yale, discovered a special DNA sequence TTAGGG in humans that is found nearly identically at the telomeres of nearly every type of animal and plant species. The telomeres protect the ends of the chromosomes and prevent them from opening up, which could result in separation of the two strands of DNA. Thus, the telomeres act as clamps on the ends of the chromosomes. In humans, there are thousands of these segments at the end of a chromosome.

Later, in Dr. Blackburns laboratory at the University of California at Berkeley, she and Dr. Carol Grieder, then a research fellow, discovered an enzyme central to aging and cancer, which they named telomerase.

Though Drs. Gall, Blackburn and Greider did not set out to answer questions about aging, telomerase has provided answers. The sequencing of the telomeres and the discovery of telomerase has lead to an entirely new field of research that has yielded insights into the mechanisms of aging and the causes of cancer.

Because most human cells have limited amounts of telomerase, they have a limited lifespan. Adding telomerase to human cells in culture dishes makes cells immortal, giving telomerase a dark side: almost all cancer cells produce telomerase to fuel their uncontrollable proliferation. Drugs that inhibit telomerase are currently being sought as potential new treatme
'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. Columbia study shows widely used artery clearing device does not help patients during heart attack
3. Columbia scientists develop cancer terminator viruses
4. Contaminants linked to sturgeon decline in Columbia river
5. Columbia University licenses next-generation DNA sequencing technology
6. New bird discovered on unexplored Columbian mountain
7. Columbia scientists determine 3-dimensional structure of cells fuel gauge
8. NJIT Presidential Award winner takes stem cell research another step
9. TGen awarded $7.1 million to accelerate brain disease research
10. Virtual microscopy project wins educational technology award
11. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... of gut bacteria called Clostridium ramosum , coupled with ... work is published this week in mBio , the ... , A research team from the German Institute of Human ... bacteria including C. ramosum gained weight when fed ... ramosum were less obese even when consuming a high-fat ...
(Date:9/29/2014)... September 29, 2014 -- Plants have a symbiotic ... the pants extract nutrients and defend against invaders ... contaminating fruits and vegetables. Now, scientist have discovered ... of seeds; thus ensuring that sprouting plants are ... University of Notre Dame, presented their findings today ...
(Date:9/29/2014)... story from 2009, "human activities in this area of the ... oil is increasingly grown for use as a cooking oil ... It has become the most widely produced edible oil in ... surpass that of soybean oil. , The environmental effects of ... to grow the crop, and the preferred method is fire. ...
Breaking Biology News(10 mins):Gut bacteria promote obesity in mice 2Plants prepackage beneficial microbes in their seeds 2
... Ore. The invasion of predatory lionfish in the Caribbean ... ecosystems a new study has found that within a ... the survival of other reef fishes is slashed by about ... of marine life, the loss of herbivorous fish also sets ...
... and packaged for food service and salad mixes is ... is highly perishable, and the cutting required in processing ... and other fresh produce in semipermeable plastic films extends ... success of modified-atmosphere (MA) packaging for lettuce and certain ...
... Hawkins was a 19th-century British artist and naturalist who ... and its pre-human inhabitants. Hawkins drew worldwide attention in ... dinosaur skeleton, Hadrosaurus foulkii , at The Academy ... prepares to remount a cast of Hadrosaurus in November, ...
Cached Biology News:Lionfish decimating tropical fish populations, threaten coral reefs 2Lionfish decimating tropical fish populations, threaten coral reefs 3Good breeding increases shelf life 2Academy publishes first biography of artist-naturalist Benjamin Waterhouse Hawkins 2Academy publishes first biography of artist-naturalist Benjamin Waterhouse Hawkins 3
(Date:9/30/2014)... , Sept. 30, 2014  KemPharm, Inc., ... discovery and development of proprietary new molecular entity ... Patent and Trademark Office (USPTO) issued U.S. Patent ... entitled, "Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl ... Making and Use Thereof." The patent, ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 The custom ... ISPE Boston Product Show 2014. The Boston Area Chapter ... the 23rd annual, day-long event for Wed., Oct. 1 ... promises to be the largest in ISPE Boston’s long ... upward of 3,000 attendees expected. , HOLLOWAY AMERICA ...
(Date:9/30/2014)... UFP Technologies, a producer of ... recently introduced a custom insulated shipping container to ... new insulated shipper solves the issue of temperature ... Technologies’ BioShell is a universal storage container which ... and shipping. The insulated shipper keeps frozen BioShells ...
(Date:9/29/2014)... is at the forefront of diagnostics today, with ... (computerized tomography), scanning, and NMR (nuclear magnetic resonance) ... persisting problems of image resolution and quality still ... living tissue. A solution is hyperpolarization, which involves ... imaging quality by following the distribution and fate ...
Breaking Biology Technology:KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3
... 6 Halozyme Therapeutics, Inc.,(Nasdaq: HALO ), ... extracellular matrix for the drug delivery,endocrinology, oncology, and ... and nine months ended September 30, 2008., ... and I am,pleased with the initiation of our ...
... Brad Thompson, President,and CEO of Oncolytics Biotech Inc. (TSX: ... Company at the Rodman & Renshaw 10th Annual,Healthcare Conference ... The,event will be held at the New York Palace ... webcast of the presentation will be available at:, http://www.wsw.com/webcast/rrshq14/oncy ...
... * Submitted NDA with FDA for NGX-4010 for management of pain associated ... ... Day 120 questions regarding MAA under ... Calif., Nov. 6 NeurogesX, Inc.,(Nasdaq: NGSX ), a biopharmaceutical company focused ...
Cached Biology Technology:Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 2Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 3Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 4Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 5Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 6Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 7Halozyme Therapeutics Reports 2008 Third Quarter Financial Results 8Media Advisory - Oncolytics Biotech Inc. to Present at Rodman & Renshaw 10th Annual Healthcare Conference 2NeurogesX Reports Third Quarter 2008 Results 2NeurogesX Reports Third Quarter 2008 Results 3NeurogesX Reports Third Quarter 2008 Results 4NeurogesX Reports Third Quarter 2008 Results 5NeurogesX Reports Third Quarter 2008 Results 6NeurogesX Reports Third Quarter 2008 Results 7NeurogesX Reports Third Quarter 2008 Results 8NeurogesX Reports Third Quarter 2008 Results 9
... Electrophoresis Running Buffer was designed to meet ... of todays sequencing labs. As a primary ... the gel-based sequencing community Sigma has the ... meet your buffer needs. Scientists at Sigma ...
... Excalibur™ mid-, near- and far-infrared range FT-IR ... performance in their class. Yet all this ... Features: Highest-energy throughput: Having a larger ... compared to other conventional FT-IRs provides 300%,larger ...
... 8800 Genetic Analysis System, which processes two 96-well ... system adds a higher level of throughput to ... part of Beckman Coulters new GenomeLab family of ... the Biomek series liquid handers, for increased automation. ...
... cDNA Library Panels were designed for full-length ... of PCRs to identify the desired cDNA ... in a 96-well "Master Plate," where each ... Having identified the positive well(s) by gel ...
Biology Products: