Navigation Links
Columbia to award 2007 Horwitz Prize to three generations of teacher-student scientists
Date:10/3/2007

ve negative consequences, e.g. a cell could join two different chromosomes together.

The second puzzle arose following discovery of how DNA copies itself. The process cannot copy the very ends of the chromosomes. So if the DNA is copied repeatedly (as in development, when DNA of one cell is copied in all subsequent cells) the chromosome eventually shortens so much that the cells are no longer viable.

Researchers surmised that something unusual was occurring at the ends of the chromosomes, known as telomeres.

Using animal models developed by Dr. Gall, Dr. Blackburn, then a research fellow in his lab at Yale, discovered a special DNA sequence TTAGGG in humans that is found nearly identically at the telomeres of nearly every type of animal and plant species. The telomeres protect the ends of the chromosomes and prevent them from opening up, which could result in separation of the two strands of DNA. Thus, the telomeres act as clamps on the ends of the chromosomes. In humans, there are thousands of these segments at the end of a chromosome.

Later, in Dr. Blackburns laboratory at the University of California at Berkeley, she and Dr. Carol Grieder, then a research fellow, discovered an enzyme central to aging and cancer, which they named telomerase.

Though Drs. Gall, Blackburn and Greider did not set out to answer questions about aging, telomerase has provided answers. The sequencing of the telomeres and the discovery of telomerase has lead to an entirely new field of research that has yielded insights into the mechanisms of aging and the causes of cancer.

Because most human cells have limited amounts of telomerase, they have a limited lifespan. Adding telomerase to human cells in culture dishes makes cells immortal, giving telomerase a dark side: almost all cancer cells produce telomerase to fuel their uncontrollable proliferation. Drugs that inhibit telomerase are currently being sought as potential new treatme
'/>"/>

Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. Columbia study shows widely used artery clearing device does not help patients during heart attack
3. Columbia scientists develop cancer terminator viruses
4. Contaminants linked to sturgeon decline in Columbia river
5. Columbia University licenses next-generation DNA sequencing technology
6. New bird discovered on unexplored Columbian mountain
7. Columbia scientists determine 3-dimensional structure of cells fuel gauge
8. NJIT Presidential Award winner takes stem cell research another step
9. TGen awarded $7.1 million to accelerate brain disease research
10. Virtual microscopy project wins educational technology award
11. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014) Women who are poor experience higher cortisol ... elevated levels of the stress hormone, putting them ... according to a new research from the University of ... the American Journal of Human Biology , is ... it directly to the socioeconomic status of their mothers ...
(Date:8/20/2014)... A new gene therapy developed by researchers at the ... to protect mice from a life-threatening heart condition caused ... therapeutic avenue," said Yi Lai, Ph.D., the leading author ... MU School of Medicine,s Department of Molecular Microbiology and ... hope this could lead to a treatment for people ...
(Date:8/20/2014)... a colony of honeybees grows to about 4,000 members, ... cycle: the building of a special type of comb ... of experts from the Department of Neurobiology and Behaviour ... starts the reproductive cycle of honeybee colonies. The results ... Science of Nature . , Reproduction isn,t always ...
Breaking Biology News(10 mins):CU Denver researcher shows economic disparities impact infant health 2Gene therapy protects mice from lethal heart condition, MU researchers find 2Worker bees 'know' when to invest in their reproductive future 2
... LOS ANGELES In research that one day may lead to ... disease, investigators at Childrens Hospital Los Angeles have identified PDGF ... epicardial cells, one type of cell that surrounds heart muscle ... September 21 in advance of the publication of the ...
... COLUMBIA, Mo. A cancer drug that benefits people ... teaching professor of oncology at the MU College of ... that examines the efficacy of Attaxol in dogs with ... by CritiTech, a Lawrence, Kan. drug development company. ...
... long encouraged by doctors as a supplement to support heart ... and colon cancer in mice in research led by Michigan ... Cancer Research . Jenifer Fenton, a food science and ... establishing a dose limit for docosahexaenoic acid (DHA), one of ...
Cached Biology News:Childrens Hospital LA discovers growth factor essential to epicardial cell function 2MU College of Veterinary Medicine to study efficacy of cancer drug in dogs 2Fish oil linked to increased risk of colon cancer in mice 2
(Date:8/18/2014)... (PRWEB) August 19, 2014 2014 ... Industryā€¯ is a professional and in-depth research report ... basic Linalool information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
(Date:8/18/2014)... 18, 2014 BioElectronics Corporation (OTC ... medical devices said that its EVP Dr. ... CEOLIVE.TV as part of its Executive Interview ... available at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel ... investors the unique advantages of BioElectronics patented ...
(Date:8/18/2014)... Global HIV Infection Drug Market and ... Reportstack. The rate of HIV infection and the number of ... at a positive rate across the globe. It has been ... 2005 to 1.5 in 2013, with the rates for children ... changes in the infection rates has been the improved access ...
(Date:8/18/2014)... -- TNI BioTech, Inc. (OTC-BB: TNIB) ("we" or the ... of innovative therapies for autoimmune diseases in emerging nations, ... notice of TNI BioTech,s annual meeting of September 4, ... Griffin , founder and CEO of TNI BioTech Inc. ... the Annual Meeting. On behalf of our employees and ...
Breaking Biology Technology:Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4
... 2010 , , , ... and Safety Endpoints , , , ... European Medicines Agency in,2010 , , , ... focused on,women,s reproductive medicine, announces positive Phase III data from its,second pivotal study (PEARL I) for its ...
... PARIS , June 2 Cellectis ... Frederic Paques, PhD, Chief Scientific Officer, Julianne Smith , ... genome surgery, and Feng Zhang , PhD, Research Director ... results on meganucleases and genome surgery at the FASEB ...
... ... Council survey examines consumer attitudes toward food technology. , ... Washington, DC (Vocus) Junw 2, 2010 -- ... survey found that consumers support the use of food biotechnology when they consider its ...
Cached Biology Technology:PregLem Announces Positive Phase III Results for Esmya(TM) 2PregLem Announces Positive Phase III Results for Esmya(TM) 3PregLem Announces Positive Phase III Results for Esmya(TM) 4Cellectis to Present at the FASEB Summer Research Conference on Genome Engineering 2Cellectis to Present at the FASEB Summer Research Conference on Genome Engineering 3Interest in Environment & Sustainability Prevails in Food Technology Survey 2Interest in Environment & Sustainability Prevails in Food Technology Survey 3Interest in Environment & Sustainability Prevails in Food Technology Survey 4Interest in Environment & Sustainability Prevails in Food Technology Survey 5
... of large numbers of samples may be carried ... which requires minimum operator attention. System control ... and interface CE 4900. The elegant, powerful ... Windows XP and Windows 98 and 2000., The ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (F1676) or contact customer s...
... is a new product number, created ... If showing no availability yet, please ... (E6152) or contact customer service for ... diam. 11.25 6.40 in. ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: