Navigation Links
Columbia researchers report novel approach for single molecule electronic DNA sequencing
Date:9/21/2012

DNA sequencing is the driving force behind key discoveries in medicine and biology. For instance, the complete sequence of an individual's genome provides important markers and guidelines for medical diagnostics and healthcare. Up to now, the major roadblock has been the cost and speed of obtaining highly accurate DNA sequences. While numerous advances have been made in the last 10 years, most current high-throughput sequencing instruments depend on optical techniques for the detection of the four building blocks of DNA: A, C, G and T. To further advance the measurement capability, electronic DNA sequencing of an ensemble of DNA templates has also been developed. Recently, it has been shown that DNA can be threaded through protein nanoscale pores under an applied electric current to produce electronic signals at single molecule level. However, because the four nucleotides are very similar in their chemical structures, they cannot easily be distinguished using this technique. Thus, the research and development of a single-molecule electronic DNA sequencing platform is the most active area of investigation and has the potential to produce a hand-held DNA sequencer capable of deciphering the genome for personalized medicine and basic biomedical research.

A team of researchers at Columbia University, headed by Dr. Jingyue Ju (the Samuel Ruben-Peter G. Viele Professor of Engineering, Professor of Chemical Engineering and Pharmacology, Director of the Center for Genome Technology and Biomolecular Engineering), with colleagues at the National Institute of Standards and Technology (NIST) led by Dr. John Kasianowicz (Fellow of the American Physical Society), have developed a novel approach to potentially sequence DNA in nanopores electronically at single molecule level with single-base resolution. This work, entitled "PEG-Labeled Nucleotides and Nanopore Detection
'/>"/>

Contact: Beth Kwon
beth.kwon@columbia.edu
212-854-6581
Columbia University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Forensic science used to determine whos who in pre-Columbian Peru
3. Scientists reconstruct pre-Columbian human effects on the Amazon Basin
4. Winemaking goes high-tech at the University of British Columbia
5. Columbia awarded 1 of first Provocative Questions grants from NCI
6. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
7. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
8. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
9. UNH researchers find African farmers need better climate change data to improve farming practices
10. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
11. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... research, involving mice and published in the October 2014 ... , suggests that just because you can do ... team of Italian scientists have found that using marijuana ... immune system. This damage may result in autoimmune diseases ... bowel disease and rheumatoid arthritis in adulthood. , "I ...
(Date:9/30/2014)... some hope: A new research report published in October ... , explains how scientists developed a synthetic version of ... development in human and mouse eggs similar to the ... during fertilization. , "We believe that the results of ... understanding of human fertilization by providing a precise answer ...
(Date:9/30/2014)... of perilous threats in today,s ocean. From overfishing ... fragile coral ecosystems are disappearing at unprecedented rates ... of corals surrounding the island of Moorea in ... tropical environment: coral guard-crabs. New research from the ... scientist Seabird McKeon and the museum,s predoctoral fellow ...
Breaking Biology News(10 mins):Adolescent exposure to thc may cause immune systems to go up in smoke 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2Smithsonian scientists discover coral's best defender against an army of sea stars 2
... of different cancers actually share something in common ?a molecular ... microRNA (miRNA) that target key cancer genes and promote malignant ... as an emerging class of gene regulators and may also ... , The study appears online in the Proceedings of ...
... have for the first time reconstructed the Darwinian evolution ... research was led by Joe Thornton, assistant professor of ... and Evolutionary Biology, and will be published in the ... can drive the evolution of complex molecular systems ?those ...
... UT Southwestern Medical Center ophthalmologists will be the first in ... to fix nearsightedness. , "Think of it as a contact ... who is inserting the new implantable collamer lens, or ICL, ... , The ICL can replace or reduce the need for ...
Cached Biology News:Common molecular 'signature' identified in solid tumors 2Common molecular 'signature' identified in solid tumors 3Evolution of 'irreducible complexity' explained 2New 'implanted contacts' designed to fix nearsightedness 2
(Date:9/30/2014)... Fla. , Sept. 30, 2014 CORD:USE ... pleased to announce that it has entered into an ... Inc. (Tianhe) which has licensed a series of patented technologies ... cells for possible clinical applications.  Tianhe is performing Phase ... and Spain using Tianhe,s Stem ...
(Date:9/30/2014)... Md., Sept. 30, 2014 BioHealth Innovation, ... commercializing market-relevant biohealth innovations and increasing access to early-stage ... today that venture capitalist, Tania Fernandez , Ph.D., ... Dr. Fernandez will be a member of the management ... provide up to $50 million in seed and early-stage ...
(Date:9/30/2014)... September 30, 2014 Lyme Research ... of Lyme disease research at universities, today announced the ... on the identification, treatment and cure for Lyme and ... received the most applications in its history—over 20 grant ... “While we were pleased to receive so many solid ...
(Date:9/30/2014)... Whitehouse Laboratories is pleased ... Parenteral Drug Association (PDA) to host a ... container closure integrity testing. This lecture/laboratory course will examine ... philosophies detailed in the recently proposed revision to USP ... course will span container closure integrity testing (leak testing) ...
Breaking Biology Technology:CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4
... breaches - ... - ... 29 Protein Sciences Corporation,("PSC") announced today that the sale of ... Inc. (NYSE: EBS ),and its affiliate (collectively "Emergent") has been ...
... 29 /PRNewswire-FirstCall/ - Par,Pharmaceutical Companies, Inc. (NYSE: PRX ... and live webcast on Friday, August 8, 2008 at ... ended June 28, 2008. The,Company will release results after ... release will be available on the Par website at, ...
... Event Expected to Attract a Record Number of ... ... DeviceSpace(TM), the world,s,leading online medical device and diagnostics job board ... Minnesota on,Monday, September 8, 2008. The event will take place at ...
Cached Biology Technology:Protein Sciences Announces Termination of Deal to Sell to Emergent BioSolutions 2DeviceSpace(TM) to Host Medical Device and Diagnostics Career Fair in Minneapolis 2
... from KUBTEC is a dual capability system with ... representation of the specimen under test. While the ... images, the micro focus source also allows the ... standard 2D images. The 50 mm x 50 ...
... electroporation products and specialty electrodes, has developed ... experiment optimization and large volume electroporation. The ... Molecular Delivery. The days of researchers struggling ... the number of samples and cell types ...
... (PR) Competitor Assay Kits are ideal ... receptor binding compounds using fluorescence polarization ... fusion of glutathione transferase to the ... receptor [PR-LBD(GST)] and a proprietary, fluorescently ...
... Kodak Companys Molecular Imaging Systems group ... Station 4000 Digital Imaging Systems, featuring ... for comprehensive fluorescence, luminescence, radiographic and ... million pixel CCD and 10x optical ...
Biology Products: