Navigation Links
Columbia engineers patch a heart
Date:5/6/2011

Researchers at Columbia Engineering have established a new method to patch a damaged heart using a tissue-engineering platform that enables heart tissue to repair itself. This breakthrough, recently published in the Proceedings of the National Academy of Sciences http://www.pnas.org/content/early/2011/04/19/1104619108.long, is an important step forward in combating cardiovascular disease, one of the most serious health problems of our day.

Led by Gordana Vunjak-Novakovic, Professor of Biomedical Engineering at Columbia University's Fu Foundation School of Engineering and Applied Science, the researchers developed a novel cell therapy to treat myocardial infarction (heart damage that follows a heart attack). They were able, for the first time, to combine the use of human repair cells that were conditioned during in-vitro culture to maximize their ability to revascularize and improve blood flow to the infarcted tissue with a fully biological composite scaffold designed to deliver these cells to the damaged heart. With this platform, they could both keep the cells within the infarct bed (in contrast to the massive cell loss associated with infusion of cells alone) and enhance cell survival and function in the infarct bed, where most of the cells would have died because of the obstruction of their blood supply.

"We are very excited about this new technique," said Dr. Vunjak-Novakovic. "This platform is very adaptable and we believe it could be readily extended to the delivery of other types of human stem cells we are interested in to rebuild the heart muscle and further our research of the mechanisms underlying heart repair."

In effect, the Columbia Engineering team (with Amandine Godier-Fournemont and Timothy Martens as lead authors) removed the cells of a human heart musclethe myocardiumleaving a protein scaffold with intact architecture and mechanical pr
'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
212-854-3206
Columbia University
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Columbia professor to discuss good, bad aspects of choice at NJIT March 23 talk
2. Columbia engineer observes surprising behavior of cells during blood-vessel formation
3. Columbia University uses technological innovation to study bone structure
4. Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research
5. Columbia engineer part of team to receive $6.2 million DOD grant for blast research
6. Columbia University Medical Center announces 2009 Katz Prizes in Cardiovascular Research
7. Columbia University scientist devises new way to more rapidly generate bone tissue
8. Salmon smolt survival similar in Columbia and Fraser rivers
9. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
10. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
11. Chemical engineers at UCSB design molecular probe to study disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... in cellular DNA can endanger the whole organism, as ... at Ludwig-Maximilians-Universitaet (LMU) in Munich now report how byproducts ... helix. , The DNA in our cells controls the ... bodies. The instructions for this are encoded in the ... the bases adenine (A), cytosine (C), guanine (G) and ...
(Date:5/22/2013)... details on how climate change will affect interactions between ... Journal of Animal Ecology . This knowledge, they ... policymakers of how species are likely to be impacted ... growing recognition among biologists that climate change is affecting ... is going to have very important consequences for the ...
(Date:5/22/2013)... the biodiversity of pollinating insects and wild plants have ... , Researchers led by the University of Leeds and ... evidence of dramatic reductions in the diversity of species ... and 1980s. , But the picture brightened markedly after ... losses among bees, hoverflies and wild plants. ...
Breaking Biology News(10 mins):DNA damage: The dark side of respiration 2UCLA life scientists present new insights on climate change and species interactions 2UCLA life scientists present new insights on climate change and species interactions 3UCLA life scientists present new insights on climate change and species interactions 4UCLA life scientists present new insights on climate change and species interactions 5Encouraging signs for bee biodiversity 2Encouraging signs for bee biodiversity 3
... tissue as well as eradicating the tumour it is ... often causing nasty side effects. A new development ... accurate treatment for cancerous tumours by using real-time images ... combining radiation treatment with non-invasive MR imaging, would be ...
... release is available in French . ... the chilli cook-off, usually has a key secret ingredient, ... crucial proteins, which change the dynamics of cells from ... involving McGill University, the Research Institute of the McGill ...
... . , Montreal, May 19th 2009 - Cocaine ... its abuse has become widespread since the end of the ... about its effects on the human brain or the mechanisms ... Marco Leyton, of the Montreal Neurological Institute (MNI), McGill University ...
Cached Biology News:Proteomics: Finding the key ingredients of disease 2Cocaine: Perceived as a reward by the brain? 2
(Date:5/23/2013)...  Verenium Corporation (Nasdaq: VRNM ), a ... commercialization of high-performance enzymes, today announced that ... at two upcoming conferences. (Logo: http://photos.prnewswire.com/prnh/20120924/MM79973LOGO ... Second Annual Marcum LLP Microcap Conference on Thursday, May ... York City.  The presentation is scheduled to begin at ...
(Date:5/23/2013)... Korea , May 23, 2013 ... SillaJen, Inc., a private biotherapeutics and contract research ... biological products for cancer, announced today a publication ... patients treated with the oncolytic and immunotherapeutic vaccinia ... This research was published in the May 15 ...
(Date:5/23/2013)... African Ancestry , Inc., the ... African descent, today announced new product enhancements to ... all races, myDNAmix determines various ancestries included in ... Americas (Native American), East Asia, West Sub-Saharan Africa, ... Originally launched in late 2011, the enhanced product ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Bed bugs ... the university had already confirmed it. Meanwhile, My Cleaning Products ... bed bug victims fight the pests without using harmful chemical ... on May 15, 2013, the affected building was actually a ... being infested was said made on May 13 and bed ...
Breaking Biology Technology:Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 3Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... to Drink,Suite of Nutritional Supplements to Provider Services, Inc. to be ... ... 5 Millennium Biotechnologies,Inc., wholly owned subsidiary of Millennium Biotechnologies Group, ... an,amendment of it,s November 9th 2007 Master Purchase Contract with Provider,Services, ...
... for Growth in 2009 and ... ... Monsanto,s international,seed brands serve as an ideal launching pad that positions ... ramp-up,speed, Brett Begemann, Monsanto,s executive vice president of global,commercial, will tell ...
... for Mass Spectrometry ... Denver, June 2-5, 2008-, EMERYVILLE, Calif., June 5 ... it has developed a novel analytical,2-dimensional liquid chromatography mass ... sensitive,automated quantification of the active pharmaceutical compounds of MF101,the ...
Cached Biology Technology:Millennium Biotechnologies Announces an Increased Annualized Purchase Commitment Totaling $5.8M from Provider Services, Inc. 2Millennium Biotechnologies Announces an Increased Annualized Purchase Commitment Totaling $5.8M from Provider Services, Inc. 3Monsanto's Industry-Leading Seed Position Creates Accelerated Biotech Trait Opportunity in Latin America 2Monsanto's Industry-Leading Seed Position Creates Accelerated Biotech Trait Opportunity in Latin America 3Monsanto's Industry-Leading Seed Position Creates Accelerated Biotech Trait Opportunity in Latin America 4Bionovo Develops a High Throughput LC-MS/MS Method for Simultaneous Quantification of Multiple Bioactive Compounds 2Bionovo Develops a High Throughput LC-MS/MS Method for Simultaneous Quantification of Multiple Bioactive Compounds 3
Incorporating the innovative InGaAs detection system the Cary 6000i is the worlds most advanced UV-Vis-NIR spectrophotometer delivering superior signal to noise performance and outstanding sensitivit...
ABI 432 Resins • Gln(Trt) Peptide Synthesis Column...
The E. coli Expression System with Gateway Technology is designed to create E. coli expression clones containing the T7 promoter. The expression clones are ready for transformation and expression in ...
...
Biology Products: