Navigation Links
Columbia engineers develop new method to diagnose heart arrhythmias
Date:5/9/2011

New York May 9,2011 Abnormalities in cardiac conduction, the rate at which the heart conducts electrical impulses to contract and relax, are a major cause of death and disability around the world. Researchers at Columbia Engineering School have been developing a new method, Electromechanical Wave Imaging (EWI), that is the first non-invasive technique to map the electrical activation of the heart. Based on ultrasound imaging, EWI will enable doctors to treat arrhythmias more efficiently and more precisely. The study was published online in the May 9th Proceedings of the National Academy of Sciences.

Up until now, other research groups have mostly focused on measuring the electrical activation directly but invasively, through electrode contact, or non-invasively but indirectly, through complex mathematical modeling based on remote measurements. "This is an important breakthrough," said Elisa Konofagou, who led the research and is an associate professor of Biomedical Engineering and Radiology at Columbia University's Fu Foundation School of Engineering and Applied Science. "The approach we have chosen to look at the minute deformations following the electrical activation of the heart is both direct and noninvasive. Electromechanical Wave Imaging is also eminently translational as it can be incorporated into most ultrasound scanners already available in hospitals and clinics, and can be modified at little or no cost to use our technology."

Using their EWI method, the Columbia Engineering team imaged the heart with ultrasound five times faster than standard echocardiography and mapped the local deformations of the heart with their images. The researchers then looked at small regions of the heart (just a few millimeters squared) and measured how much these regions were stretched or compressed every 2/1000s of a second. This enabled them to precisely identify at what time each region of the heart began to contract, a.k.a the electromechanical activation, in all four chambers of the heart. They compared their maps with the electrical activation sequence and found they were closely correlated, both at the natural rhythm of the heart and when the heart was artificially paced.

Arrhythmias occur when the normal electrical activation sequence in the heart is disrupted and their prevalence is expected to rise, as people live longer. In some cases, effective treatments exist. For example, a pacemaker can be surgically placed or a catheter can be brought into the cardiac chambers and used to burn diseased regions of the heart or pacing leads can be implanted in the heart to bypass the diseased conduction system and replace it by artificial electrical activation. But doctors can't always tell where to ablate with a catheter or who will benefit from artificial electrical activation. EWI could help determine in advance which patients can benefit from these treatments or identify with more precision which regions of the heart should be ablated. It could also be used to adapt treatment parameters as the patient's condition evolves.

"Since ultrasound is so safe, portable, and low cost," added Dr. Konofagou, "we can imagine a future where most physicians can carry a portable ultrasound scanner the size of an iPhone and easily get a map of the activation of the heart during a routine visit." Her team has already begun to image patients with arrhythmias and compare their measurements with the gold standard of catheterization and non-contact electrode measurements. If this study is conclusive, they will then move to a larger clinical study.


'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
212-854-3206
Columbia University
Source:Eurekalert

Related biology news :

1. Columbia researchers find green roof is a cost-effective way to keep water out of sewers
2. Columbia engineers patch a heart
3. Columbia professor to discuss good, bad aspects of choice at NJIT March 23 talk
4. Columbia engineer observes surprising behavior of cells during blood-vessel formation
5. Columbia University uses technological innovation to study bone structure
6. Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research
7. Columbia engineer part of team to receive $6.2 million DOD grant for blast research
8. Columbia University Medical Center announces 2009 Katz Prizes in Cardiovascular Research
9. Columbia University scientist devises new way to more rapidly generate bone tissue
10. Salmon smolt survival similar in Columbia and Fraser rivers
11. Similar survival rates for Pacific salmon in Fraser, Columbia Rivers raises new questions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2016)... -- --> --> ... Access Management Market by Component (Provisioning, Directory Services, Password ... Size, by Deployment, by Vertical, and by Region - ... is estimated to grow from USD 7.20 Billion in ... Compound Annual Growth Rate (CAGR) of 12.2% during the ...
(Date:3/9/2016)... -- This BCC Research report provides an overview of ... (RNA Seq) market for the years 2015, 2016 and ... data analysis, and services. Use this report ... such as RNA-Sequencing tools and reagents, RNA-Sequencing data analysis, ... segment and forecast their market growth, future trends and ...
(Date:3/9/2016)... GARDENS, Fla. , March 9, 2016 /PRNewswire/ ... management authentication and enrollment solutions, today announced the ... DigitalPersona ® Altus multi-factor authentication platform. ... and InfoSec managers to step-up security where it,s ... Washington, DC . ...
Breaking Biology News(10 mins):
(Date:5/17/2016)... ... May 17, 2016 , ... ... waste reduction applications, announced today it will be showcasing ManureMagic™ at booth V1061 ... was featured in the Wall Street Journal last year and more recently made ...
(Date:5/17/2016)... ... May 17, 2016 , ... The Children’s Tumor Foundation is enthusiastic to ... globe will show their support in the fight against neurofibromatosis (NF) by lighting up ... genetic disorder that causes tumors to grow on nerves throughout the body. It affects ...
(Date:5/17/2016)... ... 2016 , ... Yukon Medical, a leading developer of innovative ... Company) to receive its Global Product Innovation Supplier of the Year Award. , ... to advancing or supporting key BD initiatives, products, processes, and customer satisfaction. , ...
(Date:5/17/2016)... , ... May 17, 2016 , ... ... prior to freezing, allowing sperm cells adequate time to move prior to and ... 30°C. These combined practices lead to improved post-thaw outcomes for male infertility treatments ...
Breaking Biology Technology: