Navigation Links
Columbia engineering innovative hand-held lab-on-a-chip could streamline blood testing worldwide
Date:7/31/2011

New York, NYJuly 31, 2011Samuel K. Sia, assistant professor of biomedical engineering at Columbia Engineering, has developed an innovative strategy for an integrated microfluidic-based diagnostic devicein effect, a lab-on-a-chipthat can perform complex laboratory assays, and do so with such simplicity that these tests can be carried out in the most remote regions of the world. In a paper published in Nature Medicine online on July 31, Sia presents the first published field results on how microfluidicsthe manipulation of small amounts of fluidsand nanoparticles can be successfully leveraged to produce a functional low-cost diagnostic device in extreme resource-limited settings.

Sia and his team performed testing in Rwanda over the last four years in partnership with Columbia's Mailman School of Public Health and three local non-government organizations in Rwanda, targeting hundreds of patients. His device, known as mChip (mobile microfluidic chip), requires only a tiny finger prick of blood, effective even for a newborn, and givesin less than 15 minutesquantitative objective results that are not subject to user interpretation. This new technology significantly reduces the time between testing patients and treating them, providing medical workers in the field results that are much easier to read at a much lower cost. New low-cost diagnostics like the mChip could revolutionize medical care around the world.

"We have engineered a disposable credit card-sized device that can produce blood-based diagnostic results in minutes," said Sia. "The idea is to make a large class of diagnostic tests accessible to patients in any setting in the world, rather than forcing them to go to a clinic to draw blood and then wait days for their results."

Sia's lab at Columbia Engineering has developed the mChip devices in collaboration with Claros Diagnostics Inc., a venture capital-backed startup that Sia co-founded in 2004. (The company has recently been named by MIT's Technology Review as one of the 50 most innovative companies in the world.) The microchip inside the device is formed through injection molding and holds miniature forms of test tubes and chemicals; the cost of the chip is about $1 and the entire instrument about $100.

Sia hopes to use the mChip to help pregnant women in Rwanda who, while they may be suffering from AIDS and sexually transmitted diseases, cannot be diagnosed with any certainty because they live too far away from a clinic or hospital with a lab. "Diagnosis of infectious diseases is very important in the developing world," said Sia. "When you're in these villages, you may have the drugs for many STDs, but you don't know who to give treatments to, so the challenge really comes down to diagnostics." A version of the mChip that tests for prostate cancer has also been developed by Claros Diagnostics and was approved in 2010 for use in Europe.

Sia's work also focuses on developing new high-resolution tools to control the extracellular environments around cells, in order to study how they interact to form human tissues and organs. His lab uses techniques from a number of different fields, including biochemistry, molecular biology, microfabrication, microfluidics, materials chemistry, and cell and tissue biology.


'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
212-854-3206
Columbia University
Source:Eurekalert

Related biology news :

1. Columbia Engineering team makes major step in improving forecasts of weather extremes
2. Columbia engineers develop new method to diagnose heart arrhythmias
3. Columbia researchers find green roof is a cost-effective way to keep water out of sewers
4. Columbia engineers patch a heart
5. Columbia professor to discuss good, bad aspects of choice at NJIT March 23 talk
6. Columbia engineer observes surprising behavior of cells during blood-vessel formation
7. Columbia University uses technological innovation to study bone structure
8. Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research
9. Columbia engineer part of team to receive $6.2 million DOD grant for blast research
10. Columbia University Medical Center announces 2009 Katz Prizes in Cardiovascular Research
11. Columbia University scientist devises new way to more rapidly generate bone tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Proove Biosciences, ... to announce the launch of the Proove Health Foundation . The Foundation ... to promote the use of personalized medicine for tackling the nation’s most-pressing healthcare ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Intelligent Implant ... by the FDA via 510(k) for sale in the United States. These components ... posterior thoraco-lumbar fusions. With one-level sales beginning in October of 2015, the company ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... deliver a talk on its first-in-class technologies for tissue stem cell counting and ... on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, Massachusetts. , ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee is pleased to ... been a volunteer member of Committee since 1987. Since then, he has served in ... treasurer and was chairman for both the program and exposition committees. In his professional ...
Breaking Biology Technology: