Navigation Links
Columbia awards 2012 Naomi Berrie Award to Drs. Christophe Benoist & Diane Mathis
Date:11/19/2012

chanisms of autoimmune diabetes. With this mouse, Drs. Benoist and Mathis uncovered the central importance of T cells in ordering the destruction of the beta cells, where these T cells develop, and why they are not destroyed in mouse models of type 1 diabetes.

Their work also is credited with reawakening researchers' interest in central (thymic) tolerance, the mechanism by which newly developed T cells learn to tolerate the animal's own cells and tissues ("self") and distinguish them from foreign invaders ("non-self"). Their studies on the AIRE protein and its control of toleranceand its role in autoimmune diseases such as type 1 diabetesis one of their critical contributions. Having uncovered the role of AIRE and the thymus in the normal development of tolerance to the pancreas and other organs, researchers now hope to learn why T cells fail to develop tolerance to beta cells in type 1 diabetes and how this failure can be reversed.

In more recent work, Drs. Benoist and Mathis have teamed with colleagues at Harvard to develop a non-invasive method to image in real-time the development of type 1 diabetes in the pancreas, by following the infiltration of the pancreas by macrophages. The technique is being explored both as a diagnostic aid and as a therapeutic biomarker to gauge the effectiveness of therapies designed to slow the attack.

Drs. Benoist and Mathis have also pioneered the study of "immunometabolism," an emerging field that explores connections between the immune system and metabolism. Interest in the field is fueled in part by the increasing rates of obesity and the role of obesity in inducing inflammation, type 2 diabetes, and other chronic diseases. They identified a microbe, segmented filamentous bacteria, which can block the development of diabetes in a mouse model. They have found that intestinal microbes may also play a role.

Drs. Benoist and Mathis are both faculty of the Department of Microbiology and Immuno
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Forensic science used to determine whos who in pre-Columbian Peru
3. Scientists reconstruct pre-Columbian human effects on the Amazon Basin
4. Winemaking goes high-tech at the University of British Columbia
5. Columbia awarded 1 of first Provocative Questions grants from NCI
6. Columbia researchers report novel approach for single molecule electronic DNA sequencing
7. MARC travel awards announced for EB 2012
8. Autism Speaks awards $1.1 million to fund high priority studies
9. NYU School of Medicine presents 2012 Dart/NYU Biotechnology Achievement Awards
10. SEBM Distinguished Scientist Awards for 2012
11. SEBM Young Investigator Awards for 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... YORK , June 18, 2015 This ... US$ Million by the following Product Segments, which includes ... Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and Nephelometric ... the US, Canada , ... Asia-Pacific , Latin America ...
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a ... announced that its U.are.U ® 4500 fingerprint ... Eateries, Inc., a San ... chain, to increase security, improve accountability and reduce ... enable instant, non-repudiable identity confirmation for employee sign ...
(Date:6/15/2015)... 2015 According to a new ... (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern ... by MarketsandMarkets, The Natural Language Processing Market is expected ... 18.4% for the forecast period 2015-2020. ... igures spread   through 155 P ages ...
Breaking Biology News(10 mins):Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5
... has been decoded. Of all the puzzles it contains, though, ... blueprint for various proteins, the building blocks of each and ... control cell division in a healthy body, for instance? And ... subdivide and control over proteins gets out of hand? ...
... at the Texas Biomedical Research Institute and Yale University have ... appears to harbor genes with a major role in the ... Genomics Computing Center (GCC), the researchers found the region by ... factors for this complex disease, a process that led them ...
... There are 640 muscles in the human body, or maybe ... all depends on whom you ask. In any case, it is ... every one into his latest work, OpenSim, a software application that ... how people move. In the legs alone there are more ...
Cached Biology News:Cell cultures from a machine 2Texas Biomed develops new approach to study depression; finding may lead to new marker for risk 2OpenSim open-source software from Stanford accurately models human motion 2OpenSim open-source software from Stanford accurately models human motion 3
(Date:6/30/2015)... ... , ... The maximum number of shares proposed to be purchased in the ... unvested restricted stock). On June 29, 2015, the last trading day prior to the ... the OTCBB was $2.29 per share. , The tender offer will expire on July ...
(Date:6/30/2015)... 2015  The University of California, San Diego,s ... UC San Diego Extension announced their third annual ...  12 – 14, 2015, at UC San Diego ... an intense exposure to best practices and the ... to biologists, process engineers and business executives planning ...
(Date:6/30/2015)... , June 30, 2015 /PRNewswire/ - RepliCel Life ... stage regenerative medicine company focused on the development ... participant in its Phase 1/2 clinical trial of ... unilateral Achilles tendinosis, has been enrolled and their ... ultrasound-guided injections. RCT-01 is comprised of non-bulbar dermal ...
(Date:6/30/2015)... ... 30, 2015 , ... Southern Illinois University Edwardsville Chancellor Julie ... president of instruction at Chippewa Valley Technical College (CVTC) and will assume her ... lead SIUE during the past three years,” Furst-Bowe said. “I want to thank ...
Breaking Biology Technology:Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 2Cryo-Cell Commences Tender Offer to Purchase its Common Stock, Up to 750,000 Shares at $3.25 per Share 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 2RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 3RepliCel Life Sciences Enrolls First Participant in Phase 1/2 Clinical Trial of RCT-01 for Chronic Achilles Tendinosis 4SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3
... Kan., Feb. 28 Aided by the Kansas,Bioscience ... go national,with specialized training programs that will keep ... continue enjoying the benefits of,cutting-edge, world-class research to ... have grown significantly in recent,years, leading to unprecedented ...
... BCRX ) today announced that its fourth quarter ... Tuesday, March 4,2008. At 8:30 a.m. Eastern Time BioCryst ... financial results and provide an update on the,Company,s programs ... by Jon,P. Stonehouse, BioCryst,s Chief Executive Officer, and Stuart ...
... of biotech contract service providers, INDIANAPOLIS, ... the life sciences, has released an extensive ... biotechnology industries,holding significant promise for Indiana,s continued ... launched a new Web site --, http://www.biocrossroadslinx.com ...
Cached Biology Technology:K-State Preparing to Share Expertise With Bioscientists 2BioCryst Pharmaceuticals to Announce Fourth Quarter and Fiscal Year 2007 Financial Results on March 4, 2008 2BioCryst Pharmaceuticals to Announce Fourth Quarter and Fiscal Year 2007 Financial Results on March 4, 2008 3BioCrossroads Launches www.biocrossroadslinx.com and Releases Report on Biopharma Discovery and Development Contract Services 2BioCrossroads Launches www.biocrossroadslinx.com and Releases Report on Biopharma Discovery and Development Contract Services 3BioCrossroads Launches www.biocrossroadslinx.com and Releases Report on Biopharma Discovery and Development Contract Services 4
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
TACS Apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
RABBIT ANTI GLYCINE...
Biology Products: