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Columbia awarded 1 of first 'Provocative Questions' grants from NCI
Date:9/19/2012

New York, NY (September 20, 2012) Columbia University Medical Center (CUMC) is one of 50 institutions selected nationwide from more than 700 applications for a "Provocative Questions" grant from the National Cancer Institute (NCI). In a departure from its traditional grant-making process, NCI solicited research proposals related to 24 questions that could lead to significant advances in cancer research. These grants represent new and different ways to identify and address research needs in cancer.

Timothy H. Bestor, PhD, an epigenetics researcher and professor of genetics and development at CUMC, was selected for his proposal, "Methylation Suicide in Cancer," which could overturn a theory of carcinogenesis that has stood for more than 20 years.

Methylation is a chemical modification of DNA that can turn genes off without altering DNA sequence. Cells use DNA methylation to lock genes in the "off" position.

Since the 1980s, scientists have thought that DNA methylation of tumor suppressor genes is a key event in carcinogenesis, driving cells to become cancer cells. However, when Dr. Bestor and his team tried to find examples of tumor progression driven by methylation (with the eventual goal of being able to turn off this methylation), they were unable to find any, either in their laboratory research on breast cancer tissue or through a literature review. This led them to an alternative hypothesis of "methylation suicide," in which methylation changes are part of the normal pathways that kill incipient cancer cells. Dr. Bestor's NCI grant supports the study of this hypothesis.

"We expect that our research will cause people to question scientific dogma, which is always good," said Dr. Bestor, who is also a member of the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian Hospital/CUMC. "Our hypothesis is one of the first alternatives to the methylation carcinogenesis model, which has gone unchallenged and
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Contact: Elizabeth Streich
estreich@columbia.edu
212-305-3689
Columbia University Medical Center
Source:Eurekalert

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