Navigation Links
Columbia awarded 1 of first 'Provocative Questions' grants from NCI
Date:9/19/2012

New York, NY (September 20, 2012) Columbia University Medical Center (CUMC) is one of 50 institutions selected nationwide from more than 700 applications for a "Provocative Questions" grant from the National Cancer Institute (NCI). In a departure from its traditional grant-making process, NCI solicited research proposals related to 24 questions that could lead to significant advances in cancer research. These grants represent new and different ways to identify and address research needs in cancer.

Timothy H. Bestor, PhD, an epigenetics researcher and professor of genetics and development at CUMC, was selected for his proposal, "Methylation Suicide in Cancer," which could overturn a theory of carcinogenesis that has stood for more than 20 years.

Methylation is a chemical modification of DNA that can turn genes off without altering DNA sequence. Cells use DNA methylation to lock genes in the "off" position.

Since the 1980s, scientists have thought that DNA methylation of tumor suppressor genes is a key event in carcinogenesis, driving cells to become cancer cells. However, when Dr. Bestor and his team tried to find examples of tumor progression driven by methylation (with the eventual goal of being able to turn off this methylation), they were unable to find any, either in their laboratory research on breast cancer tissue or through a literature review. This led them to an alternative hypothesis of "methylation suicide," in which methylation changes are part of the normal pathways that kill incipient cancer cells. Dr. Bestor's NCI grant supports the study of this hypothesis.

"We expect that our research will cause people to question scientific dogma, which is always good," said Dr. Bestor, who is also a member of the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian Hospital/CUMC. "Our hypothesis is one of the first alternatives to the methylation carcinogenesis model, which has gone unchallenged and
'/>"/>

Contact: Elizabeth Streich
estreich@columbia.edu
212-305-3689
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Winemaking goes high-tech at the University of British Columbia
2. Scientists reconstruct pre-Columbian human effects on the Amazon Basin
3. Forensic science used to determine whos who in pre-Columbian Peru
4. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
5. Engineering research centers awarded $55.5 million to innovate in nanoscale science and engineering
6. Rockefeller Universitys Pearl Meister Greengard Prize to be awarded to RNA researcher Joan Steitz
7. Yale Universitys Joan Steitz awarded 2012 Vanderbilt Prize
8. University of Illinois at Urbana-Champaign awarded 5-year grant from NASA
9. Georgetown Lombardi researcher awarded Provocative Question grant from NCI
10. 6 NARSAD Young Investigator Grants awarded to CAMH
11. ASU awarded $3 million to research solar energy technologies, launch energy Ph.D. program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... from the Copenhagen Centre for Social Evolution and Yale ... that birth weight and -length can partially predict the ... as autism and schizophrenia later in life. The study ... subsequent hospital diagnoses for up to 30 years, and ... study is published today in the Proceedings of ...
(Date:9/17/2014)... the human retinoblastoma protein gene are a leading cause ... turned to fruit fly eyes to unlock the secrets ... paper featured on the cover of the current issue ... State University researchers provide the first detailed examination of ... the human cancer gene, said Irina Pushel, MSU undergraduate ...
(Date:9/17/2014)... 1960s. The typical development phases of trees and stands ... as much as 70 percent. This was the outcome ... Universitt Mnchen based on long-term data from experimental forest ... findings were published recently in Nature Communications . ... topic, with the very survival of large forest ecosystems ...
Breaking Biology News(10 mins):Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Abnormal properties of cancer protein revealed in fly eyes 2Global change: Trees continue to grow at a faster rate 2Global change: Trees continue to grow at a faster rate 3
... York University and Rockefeller University have discovered that ... have key roles in gene regulation, can team ... are a recently discovered large class of regulatory, ... in target messenger RNA to regulate their stability ...
... natural process that repairs damage to the human ... has helped establish a method of gene therapy ... disease-causing genes. , The findings are available online ... repair process known as homologous recombination, Dr. Matthew ...
... that allows immune cells known as neutrophils to protect ... at Washington University School of Medicine in St. Louis ... the development of an arthritis-like disorder by making the ... newly identified role for the gene, Foxo3a, may open ...
Cached Biology News:NYU, Rockefeller researchers find complexity of regulation by microRNA genes 2Researchers pioneer new gene therapy technique using natural repair process 2Researchers pioneer new gene therapy technique using natural repair process 3Disabling gene defuses rheumatoid arthritis in mice 2Disabling gene defuses rheumatoid arthritis in mice 3
(Date:9/17/2014)... VIENNA , Sept. 17, 2014 ... compelling, quantitative data from a study of the cost ... at the 50 th Annual Meeting of the ... a poster session today, Christian Frois , Ph.D., ... in a series of planned Intarcia-sponsored, retrospective studies to ...
(Date:9/17/2014)... 2014 /PRNewswire/ - SQI Diagnostics Inc. (TSX-V: SQD) (OTCQX: ... proprietary technologies and products for advanced microarray diagnostics, today ... trading in the United States ... commence on September 17, 2014 on the OTCQX under ... on the TSX Venture Exchange under its existing symbol ...
(Date:9/17/2014)... 17 de septiembre de 2014  Cryoport, ... proveedor mundial de soluciones logísticas avanzadas criogénicas ... la vida, anunció hoy la contratación de ... con sede en Rótterdam, Países Bajos, para ... Europa en rápido crecimiento. Según los términos ...
(Date:9/17/2014)... Scotland , September 17, 2014 /PRNewswire/ ... new mode of action from a truly ... decade  MGB Biopharma, a biopharmaceutical ... anti-infectives, announces today that it has secured ... its lead antibacterial, MGB-BP-3, against a range ...
Breaking Biology Technology:Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 2Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 3Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 4Intarcia Reveals New Insights At EASD Meeting Characterizing The Burden Of Poor Control And Non-Adherence To Anti-Diabetic Therapies 5SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 2SQI Diagnostics to begin Trading on the OTCQX Marketplace in the United States 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 2MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 3MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 4MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 5MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 6MGB Biopharma Secures £4.0m ($6.4m) to Advance its Novel Lead Antibacterial, MGB-BP-3, into Clinical Development 7
... the Nobel Prize shows a cat resting in a ... around graphene, which, at one atom thick, is the ... A significant obstacle to realizing graphene,s potential lies in ... sleeping cat. For now, material scientists stitch individual graphene ...
... Professor Federico Rosei of the INRS Energy Materials ... the prestigious 2010 Friedrich Wilhelm Bessel Research Award given ... 25 of these awards annually to young, high level ... recognition of the caliber and scope of his research ...
... ... ... ... longUrl, so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; ...
Cached Biology Technology:Graphene's strength lies in its defects 2INRS professor Federico Rosei receives a 2010 Friedrich Wilhelm Bessel Research Award 2YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 2YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 3YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 4YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 5YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 6YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 7YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 8YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 9YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 10YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 11YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 12YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 13YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results 14