Session Information: P02.053, Cerebrovascular Disease II
Presentation Time: Tuesday, March 19, 7:30 am:00pm
Melatonin, Light & Noise Reduction to Improve Sleep in the Neurological Intensive Care Unit
Authors: Brandon Foreman, Jan Claassen, Carl Bazil
Background/Significance: Sleep in the ICU is often abnormal, because of deficient melatonin production and ambient light and sound levels. Given the cognitive, autonomic, and metabolic impact of sleep deprivation, both supplemental melatonin and mitigation of environmental disruption in the ICU have been tried, with varying results. Sleep has not been studied in neurological ICU patients. This study sought to determine whether total sleep time in 12 brain-injured ICU patients could be increased through the use of melatonin and mitigating environmental disruptions. No difference in sleep time was observed between test and control subjects. However, most patients could not be scored using standard criteria. A larger patient sample size or alternative methods of scoring sleep are needed to better evaluate the use of sleep interventions in brain-injured patients.
Session Information: P01.025, Neurocritical Care: Clinical Neurophysiology/Therapeutics
Presentation Time: Monday, March 18, 2:00 pm:30 pm
A Novel Mutation in the Mitochondrial DNA Cytochrome b Gene (MTCYB) in a Patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome
Authors: Valentina Emmanuele, Evangelia Sotiriou, Purificacion Gutierrez Rios, Jaya Ganesh, Rebecca Ichord, A. Reghan Foley, H. Orhan Akman, Salvatore DiMauro.
Background/Significance: This study describes a novel mutation in the mitochondrial DNA cytochrome b (MTCYB) gene in a pa
|Contact: Karin Eskenazi|
Columbia University Medical Center