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Columbia University Medical Center/NY-Presbyterian experts at AAN
Date:3/18/2013

introductory talk in a session on new basic science developments in Parkinson's. He will also address both motor and nonmotor features of the disease, available therapeutics, and the unmet needs of patients.

Session Information: IN2,Integrated Neuroscience Session:New Insights into Molecular Mechanisms in Parkinson's Disease

Presentation Time: Sunday, March 17,2:00 pm:30 pm

Mitochondrial Encephalomyopathies: 50 Years On

Speaker: Salvatore DiMauro

Background/Significance: On the 50th anniversary of the description of the first patient with a bona fide mitochondrial myopathy, Dr. Mauro will take stock of the extraordinary and ongoing progress in mitochondrial neurology. After briefly reviewing the pre-molecular era and offering a restrictive definition of mitochondrial diseases as those involving the respiratory chain and oxidative phosphorylation, he will discuss where we stand, and what the challenges are, in six areas: mitochondrial DNA (mtDNA)-related diseases; nuclear DNA (nDNA)-related diseases (including "direct" and "indirect" hits); disorders due to faulty intergenomic communication; disorders of the respiratory chain lipid milieu; mitochondrial dynamics; and therapeutic achievements and challenges.

Presentation Time: Tuesday, March 19, 9:00 am:00 pm

Session Information: Robert Wartenberg Lecture, Presidential Plenary Session

LRRK2 G2019S Impairs Chaperone-Mediated Autophagy in Neurons

Authors: Sheng-Han Kuo, Samantha Orenstein, Hiroshi Koga, Guomei Tang, Ellen Kanter, Roy Alcalay, Ana Maria Cuervo, David Sulzer

Background/Significance: This study was designed to explore whether leucine-rich repeat kinase 2 (LRRK2) mutation causes dysfunctional chaperone-mediated autophagy (CMA) in neuronal culture models and post-mortem Parkinson's disease (PD) brains. LRRK2 mutation is the major genetic cause of PD, and most LRRK2 PD cases exhibit α-synuclein containing Le
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Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

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