Navigation Links
Columbia Engineering and Penn researchers increase speed of single-molecule measurements
Date:3/18/2012

New York, NYMarch 18, 2012As nanotechnology becomes ever more ubiquitous, researchers are using it to make medical diagnostics smaller, faster, and cheaper, in order to better diagnose diseases, learn more about inherited traits, and more. But as sensors get smaller, measuring them becomes more difficultthere is always a tradeoff between how long any measurement takes to make and how precise it is. And when a signal is very weak, the tradeoff is especially big.

A team of researchers at Columbia Engineering, led by Electrical Engineering Professor Ken Shepard, together with colleagues at the University of Pennsylvania, has figured out a way to measure nanoporestiny holes in a thin membrane that can detect single biological molecules such as DNA and proteinswith less error than can be achieved with commercial instruments. They have miniaturized the measurement by designing a custom integrated circuit using commercial semiconductor technology, building the nanopore measurement around the new amplifier chip. Their research will be published in the Advance Online Publication on Nature Methods's website on 18 March at 1400 (2pm) US Eastern time/ 1800 London time.

Nanopores are exciting scientists because they may lead to extremely low-cost and fast DNA sequencing. But the signals from nanopores are very weak, so it is critically important to measure them as cleanly as possible.

"We put a tiny amplifier chip directly into the liquid chamber next to the nanopore, and the signals are so clean that we can see single molecules passing through the pore in only one microsecond," says Jacob Rosenstein, a Ph.D. candidate in electrical engineering at Columbia Engineering and lead author of the paper. "Previously, scientists could only see molecules that stay in the pore for more than 10 microseconds."

Many single-molecule measurements are currently made using optical techniques, which use fluorescent molecules that emit photons
'/>"/>

Contact: Holly Evarts
holly@engineering.columbia.edu
347-453-7408
Columbia University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Columbia engineers map energy use in NYC buildings
2. New Columbia engineering technique diagnoses non-periodic arrhythmias in a single heartbeat
3. Columbia River salmon are adapting to climate change
4. Columbia engineering innovative hand-held lab-on-a-chip could streamline blood testing worldwide
5. Columbia Engineering team makes major step in improving forecasts of weather extremes
6. Columbia engineers develop new method to diagnose heart arrhythmias
7. Columbia researchers find green roof is a cost-effective way to keep water out of sewers
8. Columbia engineers patch a heart
9. Columbia professor to discuss good, bad aspects of choice at NJIT March 23 talk
10. Columbia engineer observes surprising behavior of cells during blood-vessel formation
11. Columbia University uses technological innovation to study bone structure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Columbia Engineering and Penn researchers increase speed of single-molecule measurements
(Date:5/18/2015)... -- Fingerprint Cards (FPC) has received an order ... FPC1035 from one if its module partners. Deliveries are planned ... and the sensors will be used by smartphone manufacturers in ... hereby amount to 740 MSEK to date. In addition to ... a number of smaller orders not separately communicated amounting to ...
(Date:5/14/2015)... May 14, 2015  Verificient Technologies, Inc., ... and online remote proctoring, announced a new ... company and creator of the Canvas Learning ... two companies will benefit from the seamless ... As a fully integrated multifactor biometrics ...
(Date:5/11/2015)... Ohio , May 11, 2015  Through a well-rounded ... Ohio had a strong showing at AUVSI,s Unmanned ... These representatives of Ohio,s UAS industry ... and abroad from all points along the UAS ecosystem. ... Development Coalition,s (DDC) Vice President for Aerospace Rich Knoll ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
... Fla. If worms could talk, they might tell ... with that telltale come slither look. But worms send ... chemical code researchers are now cracking, according to a ... Nature . Scientists from the University of ...
... fire is currently burning through a study area where projections ... used data and analysis from the Gotchen Late-Successional Reserve (LSR) ... where the Cold Springs fire is now active. The Gotchen ... in Washington, and covers about 15,000 acres of the Mount ...
... a domestic renewable fuel source could generate enough electricity ... America,s entire consumption needs and lead to a significant ... research published today, Thursday, 24 July, in the Institute ... journal paper, ,Cow Power: The Energy and Emissions Benefits ...
Cached Biology News:Mate or hibernate? That's the question worm pheromones answer 2Mate or hibernate? That's the question worm pheromones answer 3Landscape study may offer solutions for fire managers 2Cow power could generate electricity for millions 2
(Date:6/3/2015)... Intelligent Implant Systems, LLC is ... No. 9,044,273, underpinning the Revolution™ Spinal System. Revolution™ ... implant procedure by eliminating complicated reusable non-sterile instrument ... instrument tray. The implants, designed specifically for this ... technology. Intelligent Implant Systems has additional patents on ...
(Date:6/2/2015)... and TORONTO , June 2, ... TSX: APS), a clinical-stage company developing new therapeutics that ... the U.S. Food and Drug Administration (FDA) has granted ... treatment of acute myeloid leukemia (AML). APTO-253, a first-in-class ... product candidate in a Phase Ib clinical trial in ...
(Date:6/2/2015)... DUBLIN , June 02, 2015 Research ... the "Molecular Diagnostics - Global Market Size, Strategy ... their offering. "Molecular Diagnostics - Global Market ... data that analysts and planners can use. Hundreds of ... 2015 United States Medicare Fee Payment Schedules to help ...
(Date:6/2/2015)... 2015 Cirrascale Corporation ®, ... rackmount computing and storage infrastructure for conventional and ... its high density scale-out, two-in-one video delivery and ... . The high density, two-in-one system supports the ... with Intel® Iris™ Pro graphics P6300 and provides ...
Breaking Biology Technology:Intelligent Implant Systems Announces US Patent Attained for Revolution™ Spinal System 2Aptose Biosciences Granted Orphan Drug Designation by the U.S. FDA for APTO-253 in Acute Myeloid Leukemia 2Aptose Biosciences Granted Orphan Drug Designation by the U.S. FDA for APTO-253 in Acute Myeloid Leukemia 3Aptose Biosciences Granted Orphan Drug Designation by the U.S. FDA for APTO-253 in Acute Myeloid Leukemia 4Global Molecular Diagnostics Report 2015-2019 - Market Size, Strategy and Forecasts 2Global Molecular Diagnostics Report 2015-2019 - Market Size, Strategy and Forecasts 3Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 2Cirrascale® Announces Support for Intel® Xeon® Processor E3-1200 v4 Product Family; Launches Server Offering Optimized for Low Cost-per-Stream Transcoding Applications 3
... , THOUSAND OAKS, Calif., Sept. 14 Amgen (Nasdaq: ... Merrill Lynch Global Healthcare Conference on Thursday, Sept. 17, 2009, in ... will present at the conference. Live audio of the presentation will ... Web site, www.amgen.com, under Investors. , , ...
... , BOTHELL, Wash., Sept. ... a leading developer, manufacturer, and marketer of biopreservation tools ... will distribute the Company,s proprietary HypoThermosol and CryoStor biopreservation ... agreement. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20090814/BIOLIFELOGO ...
... SUNNYVALE, Calif., Sept. 14 Pharmacyclics, Inc. (Nasdaq: ... commercializing innovative small molecule drugs for the treatment of immune ... financial results for the fourth quarter and fiscal year ended ... September 17, 2009 at 1:30 p.m. PDT (4:30 p.m. EDT). ...
Cached Biology Technology:BioLife Solutions Announces HypoThermosol(R) and CryoStor(TM) Distribution Agreement With Sigma-Aldrich 2BioLife Solutions Announces HypoThermosol(R) and CryoStor(TM) Distribution Agreement With Sigma-Aldrich 3Pharmacyclics Announces Date of Fourth Quarter and Fiscal Year End 2009 Conference Call 2
... strength adhesive system which facilitates the easy removal ... either side of the frame are of differing ... has an easy release adhesive whereas the reverse, ... bond. This means that when the coverslip is ...
... General description: Humidity wells in the ... maintain chamber humidity and probe hydration around ... seal eliminates the risk of waterbath contamination. ... constant temperature waterbaths or hybridisation ovens. Linkage: ...
... Synthesis and Labeling Kit generates labeled cDNA ... unmodified cDNA is made via a reverse ... Oligo(dT) primer. Unlike other methods, there are ... reverse transcription reaction. This unmodified cDNA is ...
The Piezo Power MicroDissection (PPMD) system is designed for rapid isolation of single cells or small cell areas...
Biology Products: