Navigation Links
Colorful spy tactics track live cells supporting cancerous tumors

A new advance in cellular imaging is allowing scientists to better understand the movement of cells in the area around tumors, also known as the tumor microenvironment. In a recent article published in Disease Models & Mechanisms (DMM),, Zena Werb and colleagues used optimized methods of laser microscopy to track the movement of live cells in a mouse model of breast cancer.

As a tumor grows, it triggers immune responses in the body, and recruits assistance from normal cells in order to "feed" and support the spread of the cancerous growth. The influence of the tumor on nearby cells is dependent on the microenvironment surrounding the tumor. Some immune cells and structural proteins defend the body against the tumor, while others help the tumor grow and spread.

In order to watch the activity of these cells, researchers injected fluorescent dyes near tumors in mouse models of breast cancer which also expressed fluorescently tagged cells A specially designed microscope allowed live imaging of tumor-associated cells for more than 12 hours, while retaining the high resolution necessary to watch individual cells move in real-time. They saw that subsets of immune cells move differently some migrate along blood vessels, while others remain at the border of the tumor. Additionally, changes in the tumor microenvironment, such as a reduction of oxygen, caused some immune cells to stop migrating.

This study sheds light on how certain immune cells help or hinder tumor growth. This in turn aids in identifying drug targets which can be inhibited to prevent the spread of cancer, or conversely, targets which can be stimulated to enhance the body's natural immune response to cancer. Additionally, this new imaging technique has potential beyond studying cancer, such as watching cell movement in other tissues and organs, both diseased and healthy.


Contact: Nick Birch
The Company of Biologists

Page: 1

Related biology news :

1. Colorful view for first land animals
2. Researchers view swimming tactics of tiny aquatic predators
3. Hurricane Ike tracked by ESAs Envisat
4. Defining DNA differences to track and tackle typhoid
5. Tracking prions
6. Scientists paint viruses to track their fate in the body
7. Tracking influenzas every movement
8. Scientists test device to track medication adherence in patients with HIV/AIDS
9. Tracking stroke
10. Needle-size device created to track tumors, radiation dose
11. Map is first to track global human influences on ocean ecosystems
Post Your Comments:
(Date:6/16/2016)... , June 16, 2016 ... size is expected to reach USD 1.83 billion ... Grand View Research, Inc. Technological proliferation and increasing ... applications are expected to drive the market growth. ... , The development of advanced multimodal ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
(Date:6/2/2016)... , June 2, 2016 Perimeter ... Platforms, Unmanned Systems, Physical Infrastructure, Support & Other Service  ... visiongain offers comprehensive analysis of the global ... market will generate revenues of $17.98 billion in 2016. ... DVTEL Inc, a leader in software and hardware technologies ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator (YI) ... of the Class of 2016 were selected from a pool of 128 applicants ... the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
(Date:6/23/2016)... 2016 Andrew D ... Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining ... Chicago. The result of a collaboration among several companies with expertise in toolholding, ...
Breaking Biology Technology: