Navigation Links
Colorful spy tactics track live cells supporting cancerous tumors
Date:9/16/2008

A new advance in cellular imaging is allowing scientists to better understand the movement of cells in the area around tumors, also known as the tumor microenvironment. In a recent article published in Disease Models & Mechanisms (DMM), dmm.biologists.org, Zena Werb and colleagues used optimized methods of laser microscopy to track the movement of live cells in a mouse model of breast cancer.

As a tumor grows, it triggers immune responses in the body, and recruits assistance from normal cells in order to "feed" and support the spread of the cancerous growth. The influence of the tumor on nearby cells is dependent on the microenvironment surrounding the tumor. Some immune cells and structural proteins defend the body against the tumor, while others help the tumor grow and spread.

In order to watch the activity of these cells, researchers injected fluorescent dyes near tumors in mouse models of breast cancer which also expressed fluorescently tagged cells A specially designed microscope allowed live imaging of tumor-associated cells for more than 12 hours, while retaining the high resolution necessary to watch individual cells move in real-time. They saw that subsets of immune cells move differently some migrate along blood vessels, while others remain at the border of the tumor. Additionally, changes in the tumor microenvironment, such as a reduction of oxygen, caused some immune cells to stop migrating.

This study sheds light on how certain immune cells help or hinder tumor growth. This in turn aids in identifying drug targets which can be inhibited to prevent the spread of cancer, or conversely, targets which can be stimulated to enhance the body's natural immune response to cancer. Additionally, this new imaging technique has potential beyond studying cancer, such as watching cell movement in other tissues and organs, both diseased and healthy.


'/>"/>

Contact: Nick Birch
nick@biologists.com
44-012-234-26164
The Company of Biologists
Source:Eurekalert

Page: 1

Related biology news :

1. Colorful view for first land animals
2. Researchers view swimming tactics of tiny aquatic predators
3. Hurricane Ike tracked by ESAs Envisat
4. Defining DNA differences to track and tackle typhoid
5. Tracking prions
6. Scientists paint viruses to track their fate in the body
7. Tracking influenzas every movement
8. Scientists test device to track medication adherence in patients with HIV/AIDS
9. Tracking stroke
10. Needle-size device created to track tumors, radiation dose
11. Map is first to track global human influences on ocean ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/29/2016)... LegacyXChange, Inc. (OTC: LEGX ... Protect are pleased to announce our successful effort to ... of writing instruments, ensuring athletes signatures against counterfeiting and ... athletes on LegacyXChange will be assured of ongoing proof ... Bill Bollander , CEO states, "By inserting ...
Breaking Biology News(10 mins):
(Date:5/2/2016)... ... May 02, 2016 , ... Meister ... mind, the fresh look and added functionality give the agricultural world a taste ... a dynamic shift in agriculture – from precision farming via satellites and Unmanned ...
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, ... spinal surgical procedures, today announced the completion of a significant transaction and partnership ... and future customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading ...
(Date:4/29/2016)... April 29, 2016 Elekta is ... update to its industry-leading treatment planning software, is available ... Monaco version 5.11 provides significant performance ... calculation speeds up to four times faster than in ... the industry,s gold standard Monte Carlo ...
(Date:4/28/2016)... York, NY (PRWEB) , ... April 28, 2016 ... ... QuickSTAT has made significant investments in recruiting top industry experts, and expanding its ... Platform, which provides industry-leading tools for clients to manage their clinical trial projects. ...
Breaking Biology Technology: