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Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
Date:5/4/2010

ield of chromatin dynamics and the function of nucleosomes in genome compaction," Luger said. "We're also grateful that the grant will support infrastructure and access to a network of other experts in this field. Colorado State University and our department have been very helpful in providing us with the resources to make this science possible."

Nyborg added that the team has been working together on related projects for nearly 10 years.

"We have a superb concentration of expertise that grew out of a prestigious W.M. Keck Foundation grant awarded to members of this group in January 2004," Nyborg said. "That grant, which Dr. Frank helped us obtain, provided the foundation for the research we're doing today."

The $1.2 million Keck grant allowed Nyborg, Luger, Paul Laybourn and Jeffrey Hansen the ability to apply cutting-edge techniques of structural biology and molecular genetics to address the basic question of how genes are regulated within a cell. Collectively, the team has developed a series of highly innovative and unique techniques that allow them to characterize the structural and biochemical properties of the nucleosome, and how they are modified to allow genes to be turned on and off.


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Contact: Emily Wilmsen
Emily.Wilmsen@colostate.edu
970-491-2336
Colorado State University
Source:Eurekalert  

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