Navigation Links
Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
Date:5/4/2010

g is very fundamental to life, and the environment here at CSU, and in the Department of Biochemistry and Molecular Biology, gives us a significant edge," Nyborg said.

In every living cell, bulky proteins must maneuver through the densely packed nucleosomes to access the genes so that the DNA can be copied first into RNA and then into protein. That process occurs at thousands of genes in every cell in the body and results in giving each cell its unique instructions for example, telling a liver cell how to be a liver cell and not a brain cell.

But scientists have limited understanding of how the cell gains access to individual genes that are tightly compacted into chromosomes.

"We know that nucleosomes serve to compact the DNA to fit into a cell nucleus; what remains a long-standing mystery is how genes - encoded by the DNA - are unwound from the nucleosomes to allow access for copying their instructions into proteins with a specific biological outcome for the cell," Nyborg said. "The cell faces an enormous paradox it must tightly wrap the DNA around nucleosomes for compaction, but at the same time it must unwrap the DNA at specific sites to turn a gene on."

The key to this process is manipulating the nucleosomes. The cell must strategically move or remove nucleosomes from the DNA to gain access to the underlying gene.

To understand more about how genes function in their densely packed intracellular environment, the three women will tackle three independent, yet highly interdependent biochemistry research projects through the grant:

  • Nyborg will tackle basic biochemistry that will reveal how the nucleosomes are disassembled to expose the DNA of the gene. She has developed a unique experimental system in a test-tube that resembles the process of nucleosome movement in a living cell. This system will provide a much greater understanding of nucleosome dynamics. Nyborg has been honored for her teaching and
    '/>"/>

Contact: Emily Wilmsen
Emily.Wilmsen@colostate.edu
970-491-2336
Colorado State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. A howling success: The fifth howler monkey census on Barro Colorado Island
2. New University of Colorado paper shows novel way to study human inflammatory disease
3. University of Colorado study shows natural antioxidants give top barn swallows a leg on competitors
4. U. of Colorado scientists create tiny RNA molecule with big implications for lifes origins
5. IADR Wilmer Souder Award presented to University of Colorado professor
6. Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
7. Colorado Rocky Mountain Region: A Geological Cornucopia
8. Colorado Sen. Ken Salazar receives Soil Stewardship Award
9. University of Colorado at Boulder awarded $1 million for biofuels research
10. Colorado Engineering Firms Win NASA Grant to Develop Innovative Insulation for Next Generation Spacecraft - Super-Insulation May Allow Future Energy Efficient Appliances
11. Bugging out: NC State researchers help track wayward pests through mapping
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
(Date:3/23/2015)... March 23, 2015  In the 2014 fiscal year, ... conviction losses. This figure accounts for a fraction of ... The Nilson Report, exceeds $11 billion globally. The polygraph ... a crime has occurred. Investor Mark Saint Juste ... Joe Paolella partnered to administer the test ...
(Date:3/20/2015)... , March 20, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... is one of the products featured in 2015 "I ... at 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 ...
(Date:3/17/2015)... March 17, 2015 MedNet Solutions ... in clinical study management systems, is pleased to ... at ARENA,s Outsourcing in Clinical Trials Southeast conference ... provides an excellent forum for MedNet to showcase ... affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... stem cells could be causing some breast cancers to develop ... cells are likely controlling cell functions in the tumor and, ... enable the disease to recur. The mutations were discovered ... Oregon Health & Science University Knight Cancer Institute. The study, ...
... August 16, 2011 Maurice Godfrey, PhD, Associate ... University of Nebraska Medical Center, was recently awarded a ... (ASHG) for his proposal titled, "Luck of the Draw ... through the Society,s 2011 Genetics Education Research Program. The ...
... oxygen takes up a hefty portion of Earth,s atmosphere: Life-sustaining ... breathe. However, very early in Earth,s history, O2 was a ... turbulent mix of primordial gases. It wasn,t until the "Great ... made any measurable dent in the atmosphere, stimulating the evolution ...
Cached Biology News:Malignant stem cells may explain why some breast cancers develop and recur 2MIT: Oxygen's watery past 2MIT: Oxygen's watery past 3
(Date:4/23/2015)... (PRWEB) April 23, 2015 Athena San ... development of executive women in San Diego’s technology and ... 17th Annual Pinnacle Awards at their Gala on April ... Hotel. Register now at http://athenasd.org/events/ , The ... the Athena San Diego vision of fostering networking, risk ...
(Date:4/23/2015)... ORLANDO, Fla. , April 23, 2015 ... . releases his book "Age Healthier Live Happier - ... kick off the Age Management Medicine Group Conference at ... - 26, 2015. ",Age Healthier Live Happier, ... looking to avoid over-medication and searching for a higher ...
(Date:4/23/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... company serving the pharmaceutical, biotechnology and medical device industries, ... the United States , today announced ... quarter of 2015 after the New York Stock Exchange ... Thursday morning, May 14, 2015 Shanghai time). The earnings ...
(Date:4/23/2015)... , April 23, 2015  Veracyte, Inc. (NASDAQ: VCYT ... definitive agreement to sell approximately $40 million of its ... the investors will purchase an aggregate of 4,907,975 shares ... per share, the closing stock price on April 22, ... existing investors, including Broadfin Capital, Camber Capital, Deerfield, Longwood ...
Breaking Biology Technology:Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 2WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 3Veracyte, Inc. Announces $40 Million Private Placement 2Veracyte, Inc. Announces $40 Million Private Placement 3Veracyte, Inc. Announces $40 Million Private Placement 4
... A variety of siRNA ... screening, require the efficient delivery of , ... studies describe performing transfections in 6 well and 24 , ... NeoFX Transfection Agent ...
... , siPORTer-96 Electroporation Chamber , , ... minimal cell mortality , Electroporate up to 96 samples ... , Deliver siRNA into primary, , ... expensive, consumable electroplates or cuvettes , ...
... , ... (10-200 nt) , Purify RNA quickly (~30 minutes) , ... , Ambion scientists have ... mir Vana RNA Isolation Kits for the preparation of , ...
Cached Biology Technology:High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 2High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 3High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 4High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 5High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 6High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 7High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 8High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 9High Throughput siRNA Delivery In Vitro: From Cell Lines to Primary Cells 10High Throughput siRNA Electroporation 2High Throughput siRNA Electroporation 3High Throughput siRNA Electroporation 4High Throughput siRNA Electroporation 5High Throughput siRNA Electroporation 6Got Small RNA? 2Got Small RNA? 3Got Small RNA? 4Got Small RNA? 5
... The lyophilization stabilizer is designed to ... and for long-term storage. There ... ingredients. It is a convenient ... 7.2, and is superior to other ...
... The CERTOMAT IS, a true benchtop incubator-shaker, has ... Having a footprint of 540 x 680 ... large incubation chamber (370 x 505 x 510mm). ... the CERTOMAT IS is ideal for shaking applications ...
... TC-3000 is one of the smallest thermal cyclers ... choice of either the 0.5ml (20 samples) or ... , Fast heating and cooling rate of ... and high performance Fast track programming with ...
... StabilZyme HRP Conjugate Stabilizer is an aqueous ... and other non-toxic stabilizing chemicals in a ... 6.7. This product contains a ... 20 ppm Proclin 300 (Rohm and Haas ...
Biology Products: