Navigation Links
Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
Date:5/4/2010

g is very fundamental to life, and the environment here at CSU, and in the Department of Biochemistry and Molecular Biology, gives us a significant edge," Nyborg said.

In every living cell, bulky proteins must maneuver through the densely packed nucleosomes to access the genes so that the DNA can be copied first into RNA and then into protein. That process occurs at thousands of genes in every cell in the body and results in giving each cell its unique instructions for example, telling a liver cell how to be a liver cell and not a brain cell.

But scientists have limited understanding of how the cell gains access to individual genes that are tightly compacted into chromosomes.

"We know that nucleosomes serve to compact the DNA to fit into a cell nucleus; what remains a long-standing mystery is how genes - encoded by the DNA - are unwound from the nucleosomes to allow access for copying their instructions into proteins with a specific biological outcome for the cell," Nyborg said. "The cell faces an enormous paradox it must tightly wrap the DNA around nucleosomes for compaction, but at the same time it must unwrap the DNA at specific sites to turn a gene on."

The key to this process is manipulating the nucleosomes. The cell must strategically move or remove nucleosomes from the DNA to gain access to the underlying gene.

To understand more about how genes function in their densely packed intracellular environment, the three women will tackle three independent, yet highly interdependent biochemistry research projects through the grant:

  • Nyborg will tackle basic biochemistry that will reveal how the nucleosomes are disassembled to expose the DNA of the gene. She has developed a unique experimental system in a test-tube that resembles the process of nucleosome movement in a living cell. This system will provide a much greater understanding of nucleosome dynamics. Nyborg has been honored for her teaching and
    '/>"/>

Contact: Emily Wilmsen
Emily.Wilmsen@colostate.edu
970-491-2336
Colorado State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. A howling success: The fifth howler monkey census on Barro Colorado Island
2. New University of Colorado paper shows novel way to study human inflammatory disease
3. University of Colorado study shows natural antioxidants give top barn swallows a leg on competitors
4. U. of Colorado scientists create tiny RNA molecule with big implications for lifes origins
5. IADR Wilmer Souder Award presented to University of Colorado professor
6. Avian flu becoming more resistant to antiviral drugs, says University of Colorado study
7. Colorado Rocky Mountain Region: A Geological Cornucopia
8. Colorado Sen. Ken Salazar receives Soil Stewardship Award
9. University of Colorado at Boulder awarded $1 million for biofuels research
10. Colorado Engineering Firms Win NASA Grant to Develop Innovative Insulation for Next Generation Spacecraft - Super-Insulation May Allow Future Energy Efficient Appliances
11. Bugging out: NC State researchers help track wayward pests through mapping
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colorado State University biochemists study how chromosomes unravel to let genes do their jobs
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Practices (GCP) audit to confirm its adherence to ... This accomplishment enables HITLAB to conduct regulated smart ... highest principles for patient safety and research quality. ... healthcare access, quality, and delivery with innovative technology," ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and ... the addition of the "Global Chemical Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the increasing demand for medical sensors in biomedical ... data for quick and correct diagnosis during surgical ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... dip in the ocean, nuclear fuel is probably the farthest thing ... of just 3 parts per billion, but it adds up. Combined, ... enough to potentially fuel the worlds nuclear power plantsfor 6,500 years., ... source since the 1960s, but previous approaches have been too expensive ...
... have discovered a biological explanation for why low levels ... why breathing treatments help SMA patients live longer. The ... SMA is a progressive neurodegenerative disease that causes muscle ... one of the most common treatment options for severe ...
... scientist Chittaranjan Kole was awarded the Outstanding Crop Scientist ... was one of three scientists to receive the award ... field of crop science. He also chaired a special ... month, "Genomics and Breeding of Climate Resilient Crops ...
Cached Biology News:Low oxygen levels may decrease life-saving protein in spinal muscular atrophy 2
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... the promotion of Nick Maroulis, Pharm.D. to the newly ... , In this position, Dr. Maroulis will continue ... the directors of our multi-site pharmacies as the company ... and during that time he has served in many ...
(Date:12/19/2014)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today ... privately held company based in Redwood ... big data platform for centralized management and processing ... on-market Genomic Management Solution, Bina-GMS 1 , empowers ... and scalable analyses to maximize the value of ...
(Date:12/19/2014)... 2014 Decision Resources Group finds that the ... 12 percent compound annual growth rate through 2023. This ... and the increasing adoption of dental implants. Growing aesthetic ... also spur demand for dental biomaterials because they can ... treatments. Other key findings from Decision Resources ...
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... pharmacies, has an expanded team of Regional Pharmaceutical ... for prescriber offices in their regions, with specific ... have a variety of Regional Pharmaceutical Care Liaisons ... in hepatitis C help prescribers understand all the ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3
... PharmSource Lead Sheet upgrades database resources to help companies serving ... , ... Springfield, VA (PRWEB) November ... Information Services, Inc. (PharmSource) announces the expansion of its PharmSource ...
... quantum computing is that it will dramatically outshine traditional ... factoring large numbers, creating uncrackable codes and simulating the ... that direction, if you,ll pardon the pun, has been ... a paper published in the journal Nature . ...
... ARBOR, Mich., Nov. 21 MichBio, the association ... service providers to its fourth annual Expo on ... Financial ShowPlace in Novi, MI. The MichBio ... industry professionals.,In addition, this year,s event attracted 56 ...
Cached Biology Technology:PharmSource Introduces Proprietary Resource for Identifying New Business Opportunities in Bio/Pharma 2Stanford: Quantum computing spins closer 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 2MichBio Expo Draws Nearly 500 Professionals; Career Day Raises Profile 3
... of the Axima range, the AXIMA-CFR ... accuracy, resolution, sensitivity and mass range, ... linear and reflectron time-of-flight analysis. The ... the generation of seamless PSD, providing ...
... new MALDI O-TOF creates a new category ... orthogonal platform that has been licensed to ... of Manitoba. , As the first single ... and collisional cooling, the prOTOF 2000 represents ...
Rat Lung Fibroblasts (RLF) (>500,000 cells)...
Rat Aortic Endothelial Cells (RAOEC) (>500,000 cells)...
Biology Products: