Navigation Links
Colon cancer screening technique shows continued promise in new study
Date:6/9/2009

Recent clinical trials show that a new colon cancer screening technique created by Northwestern University researchers has a high enough sensitivity that it could potentially be as or more successful than a colonoscopy in screening for colon cancer.

The technique uses optical technology, called low-coherence enhanced backscattering (LEBS) spectroscopy, to analyze tissue samples taken from the base of the rectum. Light shines on the tissue, scatters, and some of that light bounces back to sensors in the probe. A computer analyzes the pattern of light scattering, looking for the "fingerprint" of carcinogenesis in the nanoarchitecture of the cells.

Researchers led by Vadim Backman, professor of biomedical engineering at the McCormick School of Engineering and Applied Science, obtained biopsies from patients undergoing colonoscopies and found that LEBS could detect the presence of growths elsewhere in the colon even though it just analyzed tissue from the base of the rectum.

The results were recently published in the journal Cancer Research. Clinical trials have been conducted in collaboration with Hemant Roy, M.D., director of gastroenterology research at NorthShore University HealthSystem.

The study is a step toward clinical application of the technology, since it used tissue samples near the location where doctors may ultimately use a probe to test technology.

"If you have a precancerous lesion in one part of the colon," said Backman, "even tissue that looks normal and is located far from the lesion or polyp will have molecular and other kinds of changes. It's the biological phenomenon called the 'field effect.' No one can detect these changes earlier than we can."

The study examined tissue from 219 patients. Results showed that for advanced polyps, the test had a sensitivity of 100 percent, which means that 100 percent of patients who had polyps were correctly identified as having them.

The l
'/>"/>

Contact: Kyle Delaney
k-delaney@northwestern.edu
847-467-4010
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Western diet linked to increased risk of colon cancer recurrence
2. Pig study sheds new light on the colonisation of Europe by early farmers
3. Analysis of breast and colon cancer genes finds many areas of differences between tumors
4. Genome update defines landscape of breast and colon cancers
5. $2.7 million awarded for metastatic colon cancer research
6. Colony collapse disorder symposium added to ESA Annual Meeting
7. DNA methylation shown to promote development of colon tumors
8. Vitamin D and calcium influence cell death in the colon, researchers find
9. Novel therapeutic strategy for colon cancer treatment
10. NCI grant launches clinical trials for colon cancer screening
11. Early stage colon cancer characterized by inactivation of gatekeeper gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 15, 2015  BellBrook Labs, a leader ... announced the launch of a TR-FRET (time resolved ... Transcreener UDP Assay, a high throughput screening assay ... assay will allow for sensitive detection of hundreds ...
(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... resulting from the nations nuclear weapons program lie in ... Beneath this desert landscape about two million curies ... chemicals are captured within the stratified vadose zone below ... These paths create uncertainties about where the contaminants go ...
... including those who helped decode the entire human genome ... 1mm long. The potato cyst nematode (PCN), Globodera ... particularly devastating in developing countries where the potato is a ... of Leeds to fully sequence its DNA, hopes to shed ...
... 26 Stinger Systems, Inc.,(OTC Bulletin Board: STIY), a ... Sheriff,s Department in Kansas has,purchased Stinger Systems, S-200 projectile ... the Stinger S-200 and,clearly felt that its features were ... the ruggedness of the product as well as its ...
Cached Biology News:Where does stored nuclear waste go? 2New research to decode the genetic secrets of prolific potato pest 2
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... Wis . - Non-controlling shareholders of Billerica, Mass.-based ... for the $135 million acquisition of their affiliate molecular ... firms are part of the Bruker family of companies, ... ,Bruker Optics produces a variety of spectrometers, including Fourier ...
... - The soaring prices of oil and natural gas ... matter instead of petroleum, and both biodiesel and gasoline containing ... , ,But the oil price hike has also fueled ... compounds that are the raw material for many modern plastics, ...
... Despite recent legislative setbacks, proponents of net neutrality said ... members of the United States Senate not to take ... provisions are included. , ,The pro-neutrality group It'sOurNet ... Senate to reject the telecommunications bill following a tie ...
Cached Biology Technology:UW prof turns sugar into diesel fuel, chemicals 2UW prof turns sugar into diesel fuel, chemicals 3Net neutrality will be back, supporters vow 2Net neutrality will be back, supporters vow 3Net neutrality will be back, supporters vow 4
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
RABBIT ANTI NEOPTERIN...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
... • Dog serum is collected from fasted mixed ... age Available Anticoagulants: N-02: ... K2EDTA N-08: Potassium Oxalate ... N-05: ACD N-07: CPD ...
Biology Products: