Navigation Links
Colon cancer researchers target stem cells, discover viable new therapeutic path
Date:12/1/2013

xt, the team used an existing small-molecule inhibitor to successfully block BMI-1, thus demonstrating the clinical relevance of this approach.

Lead author Dr. Antonija Kreso writes: "Inhibiting a recognized regulator of self-renewal is an effective approach to control tumor growth, providing strong evidence for the clinical relevance of self-renewal as a biological process for therapeutic targeting."

Dr. Dick explains: "When we blocked the BMI-1 pathway, the stem cells were unable to self-renew, which resulted in long-term and irreversible impairment of tumour growth. In other words, the cancer was permanently shut down."

Surgeon-scientist Dr. Catherine O'Brien, senior co-author of the study says: "The clinical potential of this research is exciting because it maps a viable way to develop targeted treatment for colon cancer patients. It is already known that about 65% have the BMI-1 biomarker. With the target identified, and a proven way to tackle it, this knowledge could readily translate into first-in-human trials to provide more personalized cancer medicine."


'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Hardworking sisters enable insect colonies to thrive
2. Colon cancer screening guidelines may miss 10 percent of colon cancers
3. Research shows how aspirin may act on blood platelets to improve survival in colon cancer patients
4. Scientists learn how soy foods protect against colon cancer
5. New 3-D colonoscopy eases detection of precancerous lesions
6. Scientists discover thriving colonies of microbes in ocean plastisphere
7. University of Tennessee professor links massive prehistoric bird extinction to human colonization
8. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
9. Cleveland Clinic develops clinical screening program for no.1 genetic cause of colon cancer
10. Two-faced cells discovered in colon cancer
11. E. coli adapts to colonize plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Colon cancer researchers target stem cells, discover viable new therapeutic path
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center today ... School of Medicine. Funding for this $50 million capital project ... publicly launched next summer. The medical education ... Reynolds Tobacco Company complex, adjacent to 525@vine in Wake Forest ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... School Team 1 won the Colorado High School Science Bowl ... Bowl in Washington D.C., Apr. 25-29, where they will compete ... 70 high schools. The U.S. Department of Energy (DOE) ... to encourage high school students to explore math and science. ...
... second trimester markers for Down,s syndrome that are detected by ... Ultrasound in Obstetrics & Gynecology , the study,s results ... with the condition. Screening for Down,s syndrome is offered ... risk based on their age. Certain features detected during a ...
... when females choose to mate with more than one ... a team of scientists from Queen Mary, University of London, ... active role in selecting their mates, with a consistent proportion ... males each year. "Until now there has been ...
Cached Biology News:Study reveals significance of second trimester markers for Down's syndrome 2Female deer take control during the mating season 2
(Date:12/24/2014)...   BioLife Solutions , Inc. (NASDAQ: BLFS ), ... hypothermic storage and cryopreservation freeze media ... tissues  ("BioLife" or the "Company"), today announced that it will ... 2015 (the "Annual Meeting"). Because the expected date ...
(Date:12/24/2014)... 23, 2014 Earlier this year in a ... of the Adult Stem Cell Technology Center, LLC ( ASCTC ... unique property of adult tissue stem cells. His title ... Important for the Future,” embodied the essence of his message ...
(Date:12/24/2014)... According to Ross Selinger, President of Selinger ... the national office market continues to be strong, driven by ... by the third quarter’s surprising 3.9% GDP, unemployment decreasing to ... have held inflation down and the Fed is keeping interest ...
(Date:12/24/2014)... expects global cell isolation and expansion market to grow at ... about the vital drivers, restraints, trends, opportunities, strategies and challenges ... http://bit.ly/1yUxy0T , According to the report, the global market ... CAGR during near future. It expects this growth to be ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... reporting system for studying NFAT activation , ... Chao-Feng Zheng ,Stratagene , Stratagenes new PathDetect ... designed for studying the activation of the,nuclear factor ... which play an essential role in inducible gene ...
... of your choice , , ... Inc. , The PathDetect in vivo signal ... the in vivo activation of signal transduction,pathways. ... fusion trans-activator,plasmid that expresses pathway-specific trans-activator proteins ...
... Mycoplasma PCR Primer Set for fast and easy detection ... ,Yale University , D. R. Staggs ,Genetic Applications LLC ... cell cultures can substantially,reduce the potency of transfection reagents. ... the optimal amounts of LipoTAXI ...
Cached Biology Technology:Cis-Reporting System Monitors Intracellular Calcium Mobilization 2Cis-Reporting System Monitors Intracellular Calcium Mobilization 3Cis-Reporting System Monitors Intracellular Calcium Mobilization 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 5New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 2New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 3New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 4New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 5New Fusion Trans-Activator Plasmids for Studying Signal Transduction,Pathways 6Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 2Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 3
... Agarose-HR High Resolution - ... from 50 to 1000 ... for sizing PCR fragments, ... by restriction enzyme digestion, ...
... Immunogen: Synthetic peptide derived from ... mouse and rat LRP5. ... mouse LRP5 proteins. Reactivity: ... LRP5-pSEC-tag-transfected 293T cells MCF-7 T47D ...
Replacement Parts for Electrophoresis Apparatus...
...
Biology Products: