Navigation Links
Collagen-seeking synthetic protein could lead doctors to tumor locations
Date:8/29/2012

Johns Hopkins researchers have created a synthetic protein that, when activated by ultraviolet light, can guide doctors to places within the body where cancer, arthritis and other serious medical disorders can be detected.

The technique could lead to a new type of diagnostic imaging technology and may someday serve as a way to move medications to parts of the body where signs of disease have been found. In a study published in the Aug. 27-31 Online Early Edition of Proceedings of the National Academy of Sciences, the researchers reported success in using the synthetic protein in mouse models to locate prostate and pancreatic cancers, as well as to detect abnormal bone growth activity associated with Marfan syndrome.

The synthetic protein developed by the Johns Hopkins team does not zero in directly on the diseased cells. Instead, it binds to nearby collagen that has been degraded by various health disorders. Collagen, the body's most abundant protein, provides structure and creates a sturdy framework upon which cells build nerves, bone and skin. Some buildup and degradation of collagen is normal, but disease cells such as cancer can send out enzymes that break down collagen at an accelerated pace. It is this excessive damage, caused by disease, that the new synthetic protein can detect, the researchers said.

"These disease cells are like burglars who break into a house and do lots of damage but who are not there when the police arrive," said S. Michael Yu, a faculty member in the Whiting School of Engineering's Department of Materials Science and Engineering. "Instead of looking for the burglars, our synthetic protein is reacting to evidence left at the scene of the crime," said Yu, who was principal investigator in the study.

A key collaborator was Martin Pomper, a School of Medicine professor of radiology and co-principal investigator of the Johns Hopkins Center of Cancer Nanotechnology Excellence. Pomper and
'/>"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Synthetic Biology Scorecard finds federal agencies responding to bioethics report
2. Synthetic diamond steps closer to next generation of high performance electrochemical applications
3. UC Santa Barbara researchers develop synthetic platelets
4. New synthetic biology technique boosts microbial production of diesel fuel
5. A new look at proteins in living cells
6. Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
7. Molecular and protein markers discovered for liver transplant failure from hepatitis C
8. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
9. Gene network restores CF protein function
10. Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
11. Long-distance distress signal from periphery of injured nerve cells begins with locally made protein
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Collagen-seeking synthetic protein could lead doctors to tumor locations
(Date:9/29/2014)... beginning of the age of dinosaurs, gigantic reptilesdistant relatives ... and others in water and it was thought they ... University of Tennessee, Knoxville, researcher in the thigh of ... , Stephanie Drumheller, an earth and planetary sciences ... Sterling Nesbitt examined 220-million-year-old bite marks in the thigh ...
(Date:9/29/2014)... Growing Demand From Huge ... Security Concerns Continue to Propel Biometrics Market in ... is one of the fastest growing biometrics markets ... majorly in various government projects such as National ... biometrics dominates the country,s biometrics market, with other ...
(Date:9/29/2014)... Oktoberfest is here, and that means ... for a cold one, taking that first ... chemicals have reacted to form compounds that ... Reactions explains why beers get skunky, and ... brews from going bad. Learn all about ...
Breaking Biology News(10 mins):Tooth serves as evidence of 220 million-year-old attack 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 2India Biometrics Market to Surpass USD2.7 Billion by 2019, Finds TechSci Research Study 3
... 100 scientists worldwide publish joint study in Science , ... the US have been probing the genome of the ... results in some aspects have completely overturned geneticists' traditional ... Science on 2nd September. The general conclusion of the ...
... carry and spread to humans is the focus of ... distinguished professor of biochemistry and head of the department ... how insects protect themselves against infection. They think the ... researchers have made progress in understanding which molecules are ...
... the latest issue of Restoration Ecology finds that in ... Oyster reefs are self-sustaining, and are additionally attractive because ... growth, and contribute to overall ecosystem stability and quality. ... stimulate the oysters' settlement; reefs are therefore able to ...
Cached Biology News:Mouse genome much more complex than expected 2K-State researchers study insects' immune system 2
(Date:9/30/2014)... Calif. , Sept. 30, 2014 FemCap ... women,s health announces its receipt of a patent No: ... menstrual cup has also received FDA clearance in the ... and the CE in Europe. This patent is related to ... with this issuance, the company is releasing FemmyCycle Teen, ...
(Date:9/30/2014)... 30, 2014 Lyme Research Alliance ... Lyme disease research at universities, today announced the awarding ... the identification, treatment and cure for Lyme and other ... the most applications in its history—over 20 grant proposals—a ... we were pleased to receive so many solid applications ...
(Date:9/30/2014)... Georgetown, Mass. (PRWEB) September 30, 2014 ... components, products, and specialty packaging has recently introduced ... BioShell® Suspension Pack . The new insulated ... the cold chain distribution process. UFP Technologies’ BioShell ... use biopharmaceutical bags during storage, handling and shipping. ...
(Date:9/29/2014)... Each year in the US, ... attention. In the military, burn injury is a ... medical care. More than 800 service members sustained ... heal slowly, remain inflamed and often become infected, ... and functionally damaging. While developments in supportive care ...
Breaking Biology Technology:The FemmyCycle 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3Faster Healing with Fewer Scars 2
... wireless bids ,The City of Madison received bids from ... InSite Wireless to build wireless hotspots around the airport ... Monday. The winning vendor will pay the city, county and ... able to charge access fees. Certain local sites could be ...
... OpGen , a company that makes ... individuals, has completed the final stage of its $5 ... on University of Wisconsin-Madison technology, already sells its testing ... will be split between marketing that service and new ...
... that word? It was as popular in Web circles in the ... long and short of it was that the Web was going ... to consumers, either in business or retail. , ,Everybody still in ... would get better prices, and so would consumers. A real win-win ...
Cached Biology Technology:Tech Digest: Madison wireless, angels, Third Wave, Esker, Research Park 2OpGen completes $5 million investment round 2A funny thing happened on the way out of the back office 2A funny thing happened on the way out of the back office 3
Vesicle Associated Membrane Protein (VAMP 1/2)...
...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Biology Products: