Navigation Links
Collagen-seeking synthetic protein could lead doctors to tumor locations
Date:8/29/2012

Johns Hopkins researchers have created a synthetic protein that, when activated by ultraviolet light, can guide doctors to places within the body where cancer, arthritis and other serious medical disorders can be detected.

The technique could lead to a new type of diagnostic imaging technology and may someday serve as a way to move medications to parts of the body where signs of disease have been found. In a study published in the Aug. 27-31 Online Early Edition of Proceedings of the National Academy of Sciences, the researchers reported success in using the synthetic protein in mouse models to locate prostate and pancreatic cancers, as well as to detect abnormal bone growth activity associated with Marfan syndrome.

The synthetic protein developed by the Johns Hopkins team does not zero in directly on the diseased cells. Instead, it binds to nearby collagen that has been degraded by various health disorders. Collagen, the body's most abundant protein, provides structure and creates a sturdy framework upon which cells build nerves, bone and skin. Some buildup and degradation of collagen is normal, but disease cells such as cancer can send out enzymes that break down collagen at an accelerated pace. It is this excessive damage, caused by disease, that the new synthetic protein can detect, the researchers said.

"These disease cells are like burglars who break into a house and do lots of damage but who are not there when the police arrive," said S. Michael Yu, a faculty member in the Whiting School of Engineering's Department of Materials Science and Engineering. "Instead of looking for the burglars, our synthetic protein is reacting to evidence left at the scene of the crime," said Yu, who was principal investigator in the study.

A key collaborator was Martin Pomper, a School of Medicine professor of radiology and co-principal investigator of the Johns Hopkins Center of Cancer Nanotechnology Excellence. Pomper and
'/>"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related biology news :

1. Synthetic Biology Scorecard finds federal agencies responding to bioethics report
2. Synthetic diamond steps closer to next generation of high performance electrochemical applications
3. UC Santa Barbara researchers develop synthetic platelets
4. New synthetic biology technique boosts microbial production of diesel fuel
5. A new look at proteins in living cells
6. Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
7. Molecular and protein markers discovered for liver transplant failure from hepatitis C
8. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
9. Gene network restores CF protein function
10. Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
11. Long-distance distress signal from periphery of injured nerve cells begins with locally made protein
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Collagen-seeking synthetic protein could lead doctors to tumor locations
(Date:6/17/2013)... JOLLA, CA June 17, 2013 An international ... (TSRI), the Howard Hughes Medical Institute and Albert Einstein ... highly promising new anti-tuberculosis compound that attacks the tuberculosis ... represent an effort to help solve one of the ... TB and its dangerous drug-resistant strains," said Peter G. ...
(Date:6/17/2013)... 17, 2013 As mobile devices, smartphones ... secure them grows exponentially, and biometric authentication offers ... Heavy Reading Insider ( www.heavyreading.com/mobile-networks ), ... ( www.heavyreading.com ). Biometrics Offer ... for biometric authentication on smartphones, analyzing the most ...
(Date:6/17/2013)... and Entrepreneurship will be the topics under discussion ... June. For the third consecutive year, this will ... sharing of experiences among members of Academy, Business, ... students. Confirmed speakers: Elisa Martn Garijo (IBM South ... Tree) and Mary O,Donovan (Hovione), among others. E3 ...
Breaking Biology News(10 mins):New compound excels at killing persistent and drug-resistant tuberculosis 2New compound excels at killing persistent and drug-resistant tuberculosis 3New compound excels at killing persistent and drug-resistant tuberculosis 4Biometric Authentication Provides Better Mobile Device Security, Heavy Reading Finds 2Biometric Authentication Provides Better Mobile Device Security, Heavy Reading Finds 3'E3 Forum -- Education, Employment & Entrepreneurship on a Global context' 2
... functions is largely based on our family,s genetic makeup, according ... published in the international publication the Journal of Neuroscience ... how ,cost-efficient, our brain network wiring is, shedding light on ... Alex Fornito from the Melbourne Neuropsychiatry Centre at the University ...
... the important first rung of the food web each spring ... to its advantage, according to the first published findings about ... algae as a kind of antifreeze against temperatures well below ... channels and pores in ice that are hospitable to itself ...
... bugs, originally from Asia, were first detected in Pennsylvania ... and vegetables and invading homes in many parts of ... entomologists from the eastern U.S. and Canada will converge ... brown marmorated stink bug plague during the 82nd Annual ...
Cached Biology News:Better brain wiring linked to family genes 2Algal antifreeze makes inroads into ice 2Stink bug experts gather in Pennsylvania to address growing problem 2
(Date:6/18/2013)... DUBLIN , June 18, 2013 /PRNewswire/ ... http://www.researchandmarkets.com/research/4b8vj2/injectable_drug ) has announced the addition of ... Formulations [Liposomes, Microspheres, & Nanoparticles], Devices [Disposables ... Free & Auto Injectors] & Therapeutics [Diabetes ... report to their offering. ...
(Date:6/18/2013)... Though health care jobs continued to be added ... Labor Statistics -- the increase was far below the calendar ... care jobs were added in home health care and outpatient ... jobs. Overall, the U.S. unemployment rate stayed flat at 7.6 ... that a total of just over 36,000 job cuts were ...
(Date:6/18/2013)... Port Monmouth, NJ (PRWEB) June 18, 2013 ... for the AdWords advertising platform. As this directly impacts ... this to be the one of the most sweeping updates ... at Core and More Technologies recently posted a very ... not initially set a ‘must-have’ upgrade date for enhanced ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 Kitware ... today announces a new Fast-Track award from the U.S. ... design-analysis environment (IDAE) for the nuclear power industry. , ... for more than 30 years, but the United States’ ... remarkable gains in power plant utilization through improved refueling, ...
Breaking Biology Technology:Injectable Drug Delivery Market by Formulations, Devices & Therapeutics - Global Forecasts to 2017 2Injectable Drug Delivery Market by Formulations, Devices & Therapeutics - Global Forecasts to 2017 3MedZilla Employment Report for June 2013 -- Jobs in Health Care Grow, But at Slower Pace 2MedZilla Employment Report for June 2013 -- Jobs in Health Care Grow, But at Slower Pace 3Core and More Technologies Helps Organizations Migrate to Google’s Enhanced Campaign Structure 2Core and More Technologies Helps Organizations Migrate to Google’s Enhanced Campaign Structure 3Kitware to Develop an Open-Source HPC Design-Analysis Environment for Nuclear Energy Research 2
... Jan. 23, 2012 Novus International Inc., a leading ... and Verenium Corporation (Nasdaq: VRNM ), a ... commercialization of high-performance enzymes, today announced the selection of ... the two companies, strategic collaboration to advance ...
...   NeoStem, Inc. (NYSE Amex: NBS ) ... focus on cell-based therapeutic development, today announced that its Chief ... 2 clinical trial for AMR-001 for preservation of heart ... of its subsidiary, Progenitor Cell Therapy, LLC , have ...
... Jan. 23, 2012   BioLife Solutions , Inc. (OTCBB: ... hypothermic storage and cryopreservation freeze ... three additional key opinion leaders in the biobanking ... markets have joined the Company,s Scientific Advisory ...
Cached Biology Technology:First Product Candidate Moving Toward Commercialization as Result of Novus International and Verenium Collaboration 2First Product Candidate Moving Toward Commercialization as Result of Novus International and Verenium Collaboration 3First Product Candidate Moving Toward Commercialization as Result of Novus International and Verenium Collaboration 4First Product Candidate Moving Toward Commercialization as Result of Novus International and Verenium Collaboration 5Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease 2Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease 3Senior Management of NeoStem and Its Subsidiaries Invited to Speak at Seventh International Conference on Cell Therapy for Cardiovascular Disease 4BioLife Solutions Adds Clinical and Commercialization Experts to Scientific Advisory Board 2BioLife Solutions Adds Clinical and Commercialization Experts to Scientific Advisory Board 3BioLife Solutions Adds Clinical and Commercialization Experts to Scientific Advisory Board 4BioLife Solutions Adds Clinical and Commercialization Experts to Scientific Advisory Board 5
Rabbit polyclonal to Staphylococcus Enterotoxin A (HRP) ( Abpromise for all tested applications)....
... Novexin offers bespoke, cost-effective solutions for complex protein processing ... expertise and experience to help you develop a solution ... , ... transfer all methodology to ...
... is a highly scalable analysis platform ... in a workgroup or an enterprise ... 40 leading pharmaceutical, biotechnology, academic and ... streamlines genomics research at large and ...
... LC Sciences provides a genome-wide microRNA ... and proprietary probe design, which enable highly ... (1-3). We have standard arrays for mature ... latest version of the Sanger miRBase database ...
Biology Products: