Navigation Links
Collagen-seeking synthetic protein could lead doctors to tumor locations
Date:8/29/2012

Johns Hopkins researchers have created a synthetic protein that, when activated by ultraviolet light, can guide doctors to places within the body where cancer, arthritis and other serious medical disorders can be detected.

The technique could lead to a new type of diagnostic imaging technology and may someday serve as a way to move medications to parts of the body where signs of disease have been found. In a study published in the Aug. 27-31 Online Early Edition of Proceedings of the National Academy of Sciences, the researchers reported success in using the synthetic protein in mouse models to locate prostate and pancreatic cancers, as well as to detect abnormal bone growth activity associated with Marfan syndrome.

The synthetic protein developed by the Johns Hopkins team does not zero in directly on the diseased cells. Instead, it binds to nearby collagen that has been degraded by various health disorders. Collagen, the body's most abundant protein, provides structure and creates a sturdy framework upon which cells build nerves, bone and skin. Some buildup and degradation of collagen is normal, but disease cells such as cancer can send out enzymes that break down collagen at an accelerated pace. It is this excessive damage, caused by disease, that the new synthetic protein can detect, the researchers said.

"These disease cells are like burglars who break into a house and do lots of damage but who are not there when the police arrive," said S. Michael Yu, a faculty member in the Whiting School of Engineering's Department of Materials Science and Engineering. "Instead of looking for the burglars, our synthetic protein is reacting to evidence left at the scene of the crime," said Yu, who was principal investigator in the study.

A key collaborator was Martin Pomper, a School of Medicine professor of radiology and co-principal investigator of the Johns Hopkins Center of Cancer Nanotechnology Excellence. Pomper and
'/>"/>

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Synthetic Biology Scorecard finds federal agencies responding to bioethics report
2. Synthetic diamond steps closer to next generation of high performance electrochemical applications
3. UC Santa Barbara researchers develop synthetic platelets
4. New synthetic biology technique boosts microbial production of diesel fuel
5. A new look at proteins in living cells
6. Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
7. Molecular and protein markers discovered for liver transplant failure from hepatitis C
8. Method to prevent rejection of disease-fighting proteins described in Human Gene Therapy journal
9. Gene network restores CF protein function
10. Protein involved in DNA replication, centrosome regulation linked to dwarfism, small brain size
11. Long-distance distress signal from periphery of injured nerve cells begins with locally made protein
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Collagen-seeking synthetic protein could lead doctors to tumor locations
(Date:1/22/2015)... Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD and ... reports on the recent success of the Wocket™ smart wallet at CES ... smart wallet was named as one of the "11 Hot Products at ... Products Launched At CES So Far" by Newseveryday.com and "The top 10 ...
(Date:1/22/2015)...  Analyst Report Issued by Small Cap IR. In 2011, Nilson ... transactions at merchants on the leading payment cards rose to ... debit, and prepaid cards reached 6.54 billion.  Eight million credit ... usage in 2012, and credit and debit card fraud resulted ...
(Date:1/22/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/wxdglm/global_wearable ... "Global Wearable Technologies Market and Applications, Opportunities, Industry ... Forecast 2014-2020" report to their offering. ... that can be worn on the user,s body ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... group of heat-loving bacteria by researchers at the Department ... fire under next-generation biofuel production. Scientists have long ... down complex plant material such as switchgrass in order ... Conventional processes involve the addition of commercially produced enzymes ...
... rotor blades for wind turbines, self-adhesive notes, plasters ... featuring adhesives. More than 820,000 tons of adhesive were ... Adhesives Association Industrieverband Klebstoffe. To this day the ... gradually is the industry also offering adhesives made from ...
... Researchers have identified genetic markers that may influence whether ... according to a national longitudinal study of thousands of young ... Developmental Psychology , a publication of the American Psychological Association. ... related in any way to academic achievement is a big ...
Cached Biology News:BESC researchers tap into genetic reservoir of heat-loving bacteria 2Naturally adhesive 2Naturally adhesive 3Genes may play role in educational achievement, study finds 2
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... Wilmington, DE (PRWEB) January 22, 2015 ... the Pistoia Alliance, which helps companies check the legal ... set to expand to China. , As their ... companies are globally adopting software solutions built as a ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
(Date:1/22/2015)...   GenoSpace , a precision medicine software company that has ... use of genomic, imaging and other biomedical data in research ... Munson , CEO of Aspera, an IBM Company, to its ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to welcome ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2
... Troy, N.Y. Waste heat is a byproduct of ... a car to flying an aircraft or operating a ... developed new nanomaterials that could lead to techniques for ... The key ingredients for making marble-sized pellets of the ...
... VIEJO, Calif., Sept. 29, 2011 Ambry Genetics ... to provide CLIA-approved exome services for applications in ... of geneticists and medical directors, these results will ... that have eluded traditional diagnostic approaches. ...
... Sept. 29, 2011 In May 2011, Omer Bayrak made ... to be discharged from the hospital using the Freedom® ... Since returning home to wait for a matching donor heart, ... only man in Turkey who lives without a heart." ...
Cached Biology Technology:Rensselaer engineers 'cook' promising new heat-harvesting nanomaterials in microwave oven 2Ambry Genetics First to Offer Exome Sequencing Service for Clinical Diagnostics. 2Total Artificial Heart Patient Enjoys Spotlight as "The Only Man in Turkey Who Lives Without a Heart" 2Total Artificial Heart Patient Enjoys Spotlight as "The Only Man in Turkey Who Lives Without a Heart" 3
... Purity is >95%\nNEN Radiolabeled Ligands\n\nReceptor-related research has ... of new radiolabeled ligands selected to keep ... wide range of products and services for ... 400 state-of-the-art radioligands. If you do not ...
... developed using a protein engineering approach that introduced ... of wild-type DNase I. These changes markedly increase ... result is a versatile enzyme that has a ... to maintain at least 50% of peak activity ...
Rabbit polyclonal to hnRNP-U...
... DNA Ligase catalyzes the formation of a ... termini in nicked duplex DNA molecules or ... a complementary strand at 45 - 65?. ... at much higher temperatures than conventional DNA ...
Biology Products: