Navigation Links
Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
Date:3/14/2012

In preclinical studies, researchers at SRI International and Astraea Therapeutics have recently evaluated the role of a new drug receptor target that shows promise for the treatment of drug addiction.

This potential new drug target belongs to a class of receptors called the nicotinic acetylcholine receptors (nAChRs). One subtype of nAChRs, called alpha4beta2 is a well-known target for nicotine's addictive effects and the therapeutic effect of the smoking cessation drug varenicline. SRI researchers are now studying another, lesser-known subtype, called alpha3beta4 nAChR, which has recently shown to play a role in the addictive properties of cocaine, morphine, and nicotine.

Using AT-1001, a highly selective alpha3beta4 compound developed by Astraea Therapeutics, SRI researchers found that addiction processes could be disrupted. In preliminary studies, AT-1001 also reduced nicotine withdrawal symptoms such as anxiety.

Because addictive drugs act on the brain's "reward circuit," many people compulsively take them despite their harmful consequences. Feelings of pleasure are caused by the release of brain chemicals, or neurotransmitters, and their increased activity in the brain reward circuit. The key neurotransmitter in the reward circuit is dopamine, which produces changes in addictive behavior. Researchers speculate that disruption of the alpha3beta4 nAChR system using highly selective drugs such as AT-1001 may interrupt this reward circuitry.

"Currently, there are no therapeutics approved to treat addiction to stimulants such as cocaine, so it is intriguing to find a promising drug receptor target and to see that AT-1001 can indeed affect phenomena that are thought to be deeply tied to the addictive nature of cocaine and other drugs of abuse," said Taline Khroyan, Ph.D., Senior Behavioral Pharmacologist in SRI's Center for Health Sciences.

Findings from these collaborative studies were recently presented at the Society for Neuroscience Annual Meeting in a study titled "AT-1001, a Highly Selective alpha3beta4 nicotinic Receptor Antagonist is Effective in Blocking Place Preference, Behavioral Sensitization, and Withdrawal Effects of Various Drugs of Abuse." The presentation was highlighted by the Society for describing the innovative approach taken by the research team.


'/>"/>

Contact: Dina Basin
dina.basin@sri.com
650-859-3845
SRI International
Source:Eurekalert

Related biology news :

1. New mouse collaborative cross resource promises new cures and treatments for diseases
2. Collaborative Health Consortium Announces eCollaboration Forum Final Agenda for HIMSS 2012
3. Collaborative effort uncovers DNA duplications that may be responsible for genomic-based diseases
4. DFG to fund 8 new collaborative research centers
5. BGI announces collaborative research agreements with Oregon State University
6. UCSB awarded $15 million by Dow to establish collaborative institute for materials research and education
7. Louisiana State University leads collaborative effort to identify genes supporting life in extreme conditions
8. Danforth Center Collaborative Research Program receives funding to improve crop yield in Africa
9. UNC-Duke ties lead to collaborative finding about cell division & metabolism
10. The first studies utilizing the Collaborative Cross mice are published in Genome Research
11. Mouse virus erroneously linked to chronic fatigue syndrome, UCSF collaborative study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2017)... SAN FRANCISCO and MOUNTAIN VIEW, ... Zipongo , "Eating Well Made Simple," and 23andMe ... to help guide better food choices.  Zipongo can now ... only their food preferences, health goals and biometrics, but ... to certain food choices. Zipongo,s personalized food ...
(Date:3/7/2017)... March 7, 2017   HireVue , the leading ... companies identify the best talent, faster, today announced the ... Officer (CSO) and Diana Kucer as Chief ... seasoned executive team poised to drive continued growth in ... a year of record bookings in 2017. ...
(Date:3/2/2017)... 2017 Summary This report provides all ... partnering interests and activities since 2010. ... Read the full report: ... 2010 report provides an in-depth insight into the partnering activity ... On demand company reports are prepared upon purchase to ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... April 21, 2017 , ... The ... 10 categories with over 30 nominees and well as the first-year award for ... award and the event was hosted by CompanyWeek and Manufacturers Edge, among other ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... Webster Bank, today announced first round funding to three startups through the UConn ... financial support to new business startups affiliated with UConn. , The UConn Innovation ...
(Date:4/21/2017)... IN (PRWEB) , ... April 21, 2017 , ... The ... to 11 high school graduates from across the nation. The scholarships are created through ... AMA member dues. , Scholarship criteria are set by the AMA Scholarship Committee, which ...
(Date:4/21/2017)... ... ... Frederick Innovative Technology Center, Inc. (FITCI), a business incubator ... a $77,518 grant from the Rural Maryland Council (RMC) to support refurbishment of ... incubator. A non-profit corporation, FITCI is a public-private partnership of the governments of ...
Breaking Biology Technology: