Navigation Links
Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
Date:1/28/2011

This release is available in French.

Montreal, January 28, 2011 The mystery began in 1976. Adolfo Pampena was diagnosed with a rare form of cancer that caused a strange combination of symptoms and was associated with the occurrence of multiple tumours in his stomach and colon. His medical team was stumped and was unable to answer the most important questions for him and his family: the cause of his disease and the risk for future generations.

Now, 35 years later, the answers are at hand thanks to a genetic study led by investigators at the Research Institute of the McGill University Health Centre (RI MUHC), the McGill Program in Cancer Genetics at the Gerald Bronfman Centre for Clinical Research in Oncology and the Lady Davis Institute for Medical Research at the Jewish General Hospital. The study was recently published in The New England Journal of Medicine.

The researchers were able to pinpoint the gene responsible for the disease (BUB1B), which is involved in the regulation of chromosomal separation. Instability during cell division can result in chromosomes ending up in the wrong place, which can lead to the development of tumours. "The general significance of this discovery is that individuals can be seen at our genetic clinic with an unknown condition and end up with a diagnosis that is relevant to patients and their families," said Dr. William Foulkes, senior author of the study and a researcher in genetics at the RI MUHC, the Lady Davis Institute.

"My father and family were relieved that the cancer risk for other family members is much less than we thought," said Mary Pampena, Adolfo's daughter. "Now we know more about my father's genetic history and the cancers he had. We know what screening test to do in the future. This is important information for us, our children and future generations."

In another study p
'/>"/>

Contact: Julie Robert
julie.robert@muhc.mcgill.ca
51-493-419-347-1381
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related biology news :

1. White House Science Fair showcases Lemelson-MIT InvenTeams
2. New biodegradable compound facilitates bone regeneration in cases of substantial loss
3. Avoiding dairy due to lactose intolerance is unnecessary in most cases
4. New nanochemistry technique encases single molecules in microdroplets
5. Study links virus to some cases of common skin cancer
6. Exhibition showcases the art of science
7. Resilience in an aging society: GSA showcases cutting-edge meeting topics
8. Montrealers are feeding fish Prozac
9. World premiere in stem cell research in Montreal
10. CFI awards $854,098 to University of Montreal and partners
11. Researchers identify biomarkers of poor outcomes in preemies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... July 1, 2014 Smart technology emphasis ... convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. ... GOOG ), Apple Inc. (NASDAQ: AAPL ), Visa ... MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... that the second series of 30 second spots on CNBC ...
(Date:7/10/2014)... 2, 2014 It is a great honor ... appointment of the world-renowned Thoracic and Cardiovascular surgeon, Mark ... Dr. Ginsburg, with over 34 years of experience, ... and Good Samaritan Regional Medical Center. Dr. Ginsburg has ... 1980,s and is considered an expert in the implantation ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
... http://www.ptitime.com ), an established leader in manufacturing Time ... Generation II,an innovative biometric system that features a ... generation of Pyramid,s TimeTrax Bio was,released in January ... same,features as its predecessor with one-touch time and ...
... of "New Employee,Verification Act", ALEXANDRIA, Va., May ... resource management today led a coalition of,business leaders ... Act." In testimony today before the House Ways ... and CEO of SHRM,urged legislators to recognize that ...
... Chicago, Ill. May 6, 2008 A recent study ... dramatically between 1990 and 2005, but that they continue to ... products contributes nearly one-third of total mercury emissions to the ... into the relative magnitudes of the different sources of mercury ...
Cached Biology News:Pyramid Launches TimeTrax Bio Generation II 2SHRM CEO Testifies Before House Subcommittee on Social Security 2SHRM CEO Testifies Before House Subcommittee on Social Security 3Study shows mercury levels from products decreasing, though still at dangerous levels 2
(Date:7/10/2014)... 10, 2014 Senior supply chain management ... associations, addressed the challenges of “Reducing Cost, Lead Time, ... through strategic sourcing. Describing the partnership of the Bio ... Chain Management Institute ( SCMI) of the University ... 24 at the Kroc Institute of Peace and Justice ...
(Date:7/10/2014)... , July 10, 2014 Research and ... of the "International Photonic Integrated Circuit (Monolithic ... to 2019" report to their offering. ... The concept of photonic integration traces its roots ... The promise of photonic integration went unexplored and ...
(Date:7/10/2014)... journal PNAS (Proceedings of the National Academy of ... sleep deprivation have a significant effect on our metabolism. ... best time of day to test for diseases such ... effectively. , Researchers from the University of Surrey and ... between sleep deprivation, body clock disruption and metabolism, and ...
(Date:7/10/2014)... out for crude 3-D glasses, polarized glasses, and ... basic devices, used to trick the brain into ... rendered obsolete with the introduction of new holography ... TAU doctoral students Yuval Yifat, Michal Eitan, and ... on nanoantennas that could be used for security ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Time of day crucial to accurately test for diseases, new research finds 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3
... tracking are not quite here yet. But Pete Abell ... has a few words to say about when they might ... UW E-Business Institute held June 17 near Waukesha, he told ... RFID tracking as early as next year so they would ...
... disadvantages and implementation advice offered , ,Waukesha, Wis. ... open market, it seldom begins its life as an instant ... or impractical contraption that is waiting for early adopters, who ... must be studied by those experienced in the field, tested ...
... Third CATI company in 12 months , ,STURTEVANT, ... technology licensed from the Center for Advanced Technology ... a license agreement with CATI on its flexible, raised-pavement ... Bates. , ,Raised pavement markers are installed on most ...
Cached Biology Technology:RFID: a 30-year project 2Laying the foundation for RFID 2Laying the foundation for RFID 3Laying the foundation for RFID 4
Convenient 10X buffer concentrate used to maximize binding to the solid phase in microwell ELISA. Formulated to provide optimal pH and ionic strength for binding of antibodies and some antigens. Co...
A trigger solution for Flashlight labeled materials....
... The MiniOpticon 2-color real-time PCR detection system holds 48 ... array of 48 LEDs independently excites fluorescence (470-500 nm) ... detects emitted light (523-543 nm and 540-700 nm). This ... MJ Mini thermal cycler. System dimensions are 18 x ...
... novel procedure for the uniform amplification and ... DNA from small samples. This method has ... highly reproducible amplification and labeling procedure for ... Mini Kit module (QIAGEN) and a ULS ...
Biology Products: