Navigation Links
Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
Date:6/2/2008

COLD SPRING HARBOR, N.Y. (Monday, June 2, 2008) With the sequencing of the human genome came the startling revelation that the number of copies of a genes and other DNA sequences can vary widely between individuals. This copy number variation (or CNV), contributes to our species' genetic diversity but it has also been linked to genetic diseases. This month's issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc6_08.dtl) features a new method for detecting copy number variation.

"Copy Number Variation Detection Via High-Density SNP Genotyping" describes the use of PennCNV, a new computational tool for CNV detection in data from genomic arrays. Developed in the laboratory of Maja Bucan (http://www.neuorgenome.org) at the University of Pennsylvania, the software is freely available for download (http://www.neurogenome.org/cnv/penncnv/). Analysis with PennCNV will provide a more comprehensive understanding of genome variation and will aid in studies seeking the causes of genetic diseases. The protocol is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/7/pdb.top46).

The second featured method for June, "Isolation and Whole-Cell Patch Clamping of Arabidopsis Guard Cell Protoplasts," provides a method for analyzing ion differences across membranes, a vital step in understanding cellular responses to internal and external stimuli. This is particularly difficult to study in plant cells because they are surrounded by cell walls that make traditional techniques impossible. Pennsylvania State University's Sarah Assmann (http://www.bio.psu.edu/People/Fac
'/>"/>

Contact: David Crotty
crotty@cshl.edu
516-422-4007
Cold Spring Harbor Laboratory
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. Mice mothers devote energies to offspring when life is threatened
2. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
3. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. Springer expands publishing partnership with the Biomedical Engineering Society
6. Warmer springs mean less snow, fewer flowers in the Rockies
7. Springer author Carlos M. Duarte awarded Spanish science prize
8. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
9. Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology
10. Hot springs microbes hold key to dating sedimentary rocks, researchers say
11. Humana Press journals now available on SpringerLink

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...A JOLLA, CAWhen you eat may be just as vital to yo...e Salk Institute for Biological Studies. Their exp...d waning of thousands of genes in the liverthe bod... food intake and not by the body,s circadian clock...ime determines the activity of a large number of g...
(Date:11/24/2009)...ket science is opening new doors to understanding ... the hearing of a marine mammal or if they hear i...zed X-ray scanners that NASA uses to detect flaws ... is now allowing scientists to peek inside the gia...ed three-dimensional replicas of a whale,s hearing...
(Date:11/24/2009)... atomic-level action of a remarkable class of ring...rchers with the Lawrence Berkeley National Laborat...n crystallography beamline at the Advanced Light S...es in gene expression and replication, and are vit...l as infectious agents, such as the human papillom...
Breaking Biology News(10 mins):Feeding the clock 2Feeding the clock 3Rocket science leads to new whale discovery 2Atomic-level snapshot catches protein motor in action 2Atomic-level snapshot catches protein motor in action 3Atomic-level snapshot catches protein motor in action 4KV Pharmaceutical Company Purdue Pharma L P Settle OxyContin 28R 29 Dispute 48392 1KV Pharmaceutical Company Purdue Pharma L P Settle OxyContin 28R 29 Dispute 48392 2KV Pharmaceutical Company Purdue Pharma L P Settle OxyContin 28R 29 Dispute 48392 3KV Pharmaceutical Company Purdue Pharma L P Settle OxyContin 28R 29 Dispute 48392 4KV Pharmaceutical Company Purdue Pharma L P Settle OxyContin 28R 29 Dispute 48392 5KV Pharmaceutical Company Purdue Pharma L P Settle OxyContin 28R 29 Dispute 48392 6Satellite Healthcare Raises Kidney Awareness in Sacramento 48390 1Satellite Healthcare Raises Kidney Awareness in Sacramento 48390 2When young men are scarce theyre more likely to play the field than to propose 48385 1When young men are scarce theyre more likely to play the field than to propose 48385 2
...wship for Women in Science has been awarded to Flo...octoral research assistant and courtesy faculty me... year, one of just five young women scientists in ...ize. , The L,Oreal USA Fellowships for Women in S...ociation for the Advancement of Science (AAAS) -- ...
... the Cocheco River, just outside downtown Dover, s...ontaminated Sediments Center are testing an innova...erways. , Rather than dredging up the problem, or...eated a patch black geotextile mats designed to c... two years, UNH associate professor Kevin Gardner,...
...ne DRD4 is linked to better health among nomadic t...ttled cousins, according to new research by a team...f Wisconsin-Milwaukee (UWM). , A study by UWM ass...Northwestern University, Boston University and UNL..., appears to have completely different effects, de...
Other Biology News:'Women in Science' fellowship to fund postdoc's study of deep-sea methane 2'Women in Science' fellowship to fund postdoc's study of deep-sea methane 3UNH researchers test sediment-scrubbing technology in NH river 2UNH researchers test sediment-scrubbing technology in NH river 3Did the gene for ADHD help our nomadic ancestors? 2
(Date:11/24/2009)...man . , Whether it,s CD packaging, container...ncy Identification) are increasingly finding their...label objects or goods and identify them automatic...an read and process the data contained in the labe...uction conditions of up to 100 degrees Celsius. Bu...
(Date:11/24/2009)... to also Visit Detroit , ..., French Ambassador for International Investment, ...y, , , , ,What: Ambassador Appia is available to ...tiatives adopted by France to further develop the ...ation and development., , ,When: Available for Int...
(Date:11/24/2009)...Nov. 24 Two more prestigious unive...s leading online job board and careers site for li...olumbia University are now members of the job boar...stitutions. ,, The job board, www.biocareercen...ciences. While there are hundreds of life science ...
(Date:11/24/2009)...IK, Iceland, November 24 ...nced that it has received notice from,the Nasdaq S...tock will be,suspended as of November 30, 2009 and...nd Exchange Commission, which will remove deCODE,s...ompany files an appeal to the Nasdaq,Listing Quali...
Breaking Biology Technology:Intelligence inside metal components 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal 2deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal 3
...uate students Steven T. Evans, Tobias Voitl, Gabri...er Won Bae Kim. Source: UW-Madison. MADISON - Car...al barrier to the efficient operation of fuel cell...he University of Wisconsin-Madison have not only c...method to capture carbon monoxide,s energy. , ,To ...
...will not be discovered and plenty will rot in obli...ities are full steam ahead, the skateboarding math... used hockey sticks while sipping champagne, and t...rifugal forces of the Ferraris. , ,Looking from a...to be searched and to be found has finally started...
... Thursday with Capital Data, Inc. , an independen...financial services, according to TeraMEDICA,s exec...he agreement, Capital Data will bundle TeraMEDICA,...mputing and storage solutions in a territory that ... Dakota, Iowa, Illinois and Michigan. , ,TI2m is a...
Other Biology Technology:UW engineers clear bottleneck in hydrogen production 2Lord of the Engines 2Lord of the Engines 3TeraMEDICA and Capital Data enter into diagnostic imaging agreement 2
Rat Anti-Mouse Reticular Fibroblast (pan) Monoclonal Antibody, Unconjugated, Clone ER-TR7 from CEDARLANE Laboratories Limited
Mouse Anti-BCAR1 Monoclonal Antibody, Unconjugated, Clone SPM302 from Abcam
Mouse Anti-Human p21 Ras Monoclonal Antibody, Unconjugated, Clone NCC-RAS-001 from ABR-Affinity BioReagents
Rabbit Anti-GPCR G2A Polyclonal Antibody, Unconjugated from Abcam
Biology Products: