Navigation Links
Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
Date:6/2/2008

COLD SPRING HARBOR, N.Y. (Monday, June 2, 2008) With the sequencing of the human genome came the startling revelation that the number of copies of a genes and other DNA sequences can vary widely between individuals. This copy number variation (or CNV), contributes to our species' genetic diversity but it has also been linked to genetic diseases. This month's issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc6_08.dtl) features a new method for detecting copy number variation.

"Copy Number Variation Detection Via High-Density SNP Genotyping" describes the use of PennCNV, a new computational tool for CNV detection in data from genomic arrays. Developed in the laboratory of Maja Bucan (http://www.neuorgenome.org) at the University of Pennsylvania, the software is freely available for download (http://www.neurogenome.org/cnv/penncnv/). Analysis with PennCNV will provide a more comprehensive understanding of genome variation and will aid in studies seeking the causes of genetic diseases. The protocol is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/7/pdb.top46).

The second featured method for June, "Isolation and Whole-Cell Patch Clamping of Arabidopsis Guard Cell Protoplasts," provides a method for analyzing ion differences across membranes, a vital step in understanding cellular responses to internal and external stimuli. This is particularly difficult to study in plant cells because they are surrounded by cell walls that make traditional techniques impossible. Pennsylvania State University's Sarah Assmann (http://www.bio.psu.edu/People/Faculty/Assmann/Lab/), provides a protocol that describes the isolation of plant cells without cell walls and the patch clamp method of measuring electrical differences inside and outside of these cells. This method is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/7/pdb.prot5014).


'/>"/>

Contact: David Crotty
crotty@cshl.edu
516-422-4007
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Mice mothers devote energies to offspring when life is threatened
2. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
3. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. Springer expands publishing partnership with the Biomedical Engineering Society
6. Warmer springs mean less snow, fewer flowers in the Rockies
7. Springer author Carlos M. Duarte awarded Spanish science prize
8. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
9. Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology
10. Hot springs microbes hold key to dating sedimentary rocks, researchers say
11. Humana Press journals now available on SpringerLink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... announced today it will be hosting a Webinar titled, “Pathology is going digital. ... Associates , on digital pathology adoption best practices and how Proscia improves lab ...
(Date:10/11/2017)... ... ... Disappearing forests and increased emissions are the main causes of the evolving ... those living in larger cities are affected by air pollution related diseases. , That ... countries globally - decided to take action. , “I knew I had to take ...
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
(Date:10/10/2017)... ... 10, 2017 , ... Dr. Bob Harman, founder and CEO of VetStem ... The event entitled “Stem Cells and Their Regenerative Powers,” was held ... Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief ...
Breaking Biology Technology: