Navigation Links
Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells

COLD SPRING HARBOR, N.Y. (Monday, June 2, 2008) With the sequencing of the human genome came the startling revelation that the number of copies of a genes and other DNA sequences can vary widely between individuals. This copy number variation (or CNV), contributes to our species' genetic diversity but it has also been linked to genetic diseases. This month's issue of Cold Spring Harbor Protocols ( features a new method for detecting copy number variation.

"Copy Number Variation Detection Via High-Density SNP Genotyping" describes the use of PennCNV, a new computational tool for CNV detection in data from genomic arrays. Developed in the laboratory of Maja Bucan ( at the University of Pennsylvania, the software is freely available for download ( Analysis with PennCNV will provide a more comprehensive understanding of genome variation and will aid in studies seeking the causes of genetic diseases. The protocol is freely accessible on the website for Cold Spring Harbor Protocols (

The second featured method for June, "Isolation and Whole-Cell Patch Clamping of Arabidopsis Guard Cell Protoplasts," provides a method for analyzing ion differences across membranes, a vital step in understanding cellular responses to internal and external stimuli. This is particularly difficult to study in plant cells because they are surrounded by cell walls that make traditional techniques impossible. Pennsylvania State University's Sarah Assmann (, provides a protocol that describes the isolation of plant cells without cell walls and the patch clamp method of measuring electrical differences inside and outside of these cells. This method is freely accessible on the website for Cold Spring Harbor Protocols (


Contact: David Crotty
Cold Spring Harbor Laboratory

Related biology news :

1. Mice mothers devote energies to offspring when life is threatened
2. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
3. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. Springer expands publishing partnership with the Biomedical Engineering Society
6. Warmer springs mean less snow, fewer flowers in the Rockies
7. Springer author Carlos M. Duarte awarded Spanish science prize
8. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
9. Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology
10. Hot springs microbes hold key to dating sedimentary rocks, researchers say
11. Humana Press journals now available on SpringerLink
Post Your Comments:
(Date:10/27/2015)... Munich, Germany , ... (ASGM) automatically maps data from mobile eye tracking videos ... so that they can be quantitatively analyzed with SMI,s ... Germany , October 28-29, 2015. SMI,s Automated Semantic ... eye tracking videos created with SMI,s Eye Tracking ...
(Date:10/26/2015)... Calif. and LAS VEGAS ... Nok Nok Labs , an innovator in modern authentication ... , today announced the launch of its latest version ... unified platform enabling organizations to use standards-based authentication that ... Nok Nok S3 Authentication Suite is ideal for organizations ...
(Date:10/23/2015)... and GOLETA, California , October ... conference, BIOPAC and SensoMotoric Instruments (SMI) announce a mobile ... tracking data captured during interactive real-world tasks ... play integration of their established wearable solutions for eye ... synchronize gaze behavior captured with SMI Eye Tracking ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , England , November 26, 2015 /PRNewswire/ ... Medical, an innovative medical device company specializing in imaging technologies, ... from the European Commission as part of the Horizon 2020 ... company to carry out a large-scale clinical trial in breast ...      (Logo: , --> ...
(Date:11/25/2015)... ANNAPOLIS, Md. , Nov. 25, 2015  PharmAthene, ... of Directors has adopted a stockholder rights plan (Rights ... its net operating loss carryforwards (NOLs) under Section 382 ... --> --> PharmAthene,s use of its ... an "ownership change" as defined in Section 382 of ...
(Date:11/25/2015)... November 25, 2015 Studies reveal ... human plaque and pave the way for more effective treatment ... cats     --> ... diagnosed health problems in cats, yet relatively little was understood ... collaborative studies have been conducted by researchers from the WALTHAM ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. ... Gorman , President and CEO of Neurocrine Biosciences, will ... Conference in New York . ... visit the website approximately 5 minutes prior to the ... replay of the presentation will be available on the ...
Breaking Biology Technology: