Navigation Links
Cold Spring Harbor Protocols features methods for analyzing genomes and plant cells
Date:6/2/2008

COLD SPRING HARBOR, N.Y. (Monday, June 2, 2008) With the sequencing of the human genome came the startling revelation that the number of copies of a genes and other DNA sequences can vary widely between individuals. This copy number variation (or CNV), contributes to our species' genetic diversity but it has also been linked to genetic diseases. This month's issue of Cold Spring Harbor Protocols (www.cshprotocols.org/TOCs/toc6_08.dtl) features a new method for detecting copy number variation.

"Copy Number Variation Detection Via High-Density SNP Genotyping" describes the use of PennCNV, a new computational tool for CNV detection in data from genomic arrays. Developed in the laboratory of Maja Bucan (http://www.neuorgenome.org) at the University of Pennsylvania, the software is freely available for download (http://www.neurogenome.org/cnv/penncnv/). Analysis with PennCNV will provide a more comprehensive understanding of genome variation and will aid in studies seeking the causes of genetic diseases. The protocol is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/7/pdb.top46).

The second featured method for June, "Isolation and Whole-Cell Patch Clamping of Arabidopsis Guard Cell Protoplasts," provides a method for analyzing ion differences across membranes, a vital step in understanding cellular responses to internal and external stimuli. This is particularly difficult to study in plant cells because they are surrounded by cell walls that make traditional techniques impossible. Pennsylvania State University's Sarah Assmann (http://www.bio.psu.edu/People/Faculty/Assmann/Lab/), provides a protocol that describes the isolation of plant cells without cell walls and the patch clamp method of measuring electrical differences inside and outside of these cells. This method is freely accessible on the website for Cold Spring Harbor Protocols (http://www.cshprotocols.org/cgi/content/full/2008/7/pdb.prot5014).


'/>"/>

Contact: David Crotty
crotty@cshl.edu
516-422-4007
Cold Spring Harbor Laboratory
Source:Eurekalert

Related biology news :

1. Mice mothers devote energies to offspring when life is threatened
2. Cold Spring Harbor Protocols features classic approaches for analyzing chromosomes
3. Cold Spring Harbor Laboratory scientists devise potential approach to treat spinal muscular atrophy
4. Cold Spring Harbor Protocols features methods to screen genomes and analyze evolution
5. Springer expands publishing partnership with the Biomedical Engineering Society
6. Warmer springs mean less snow, fewer flowers in the Rockies
7. Springer author Carlos M. Duarte awarded Spanish science prize
8. RNA-based methods for developmental studies are featured in Cold Spring Harbor Protocols
9. Cold Spring Harbor Laboratory to play central role addressing key questions in plant biology
10. Hot springs microbes hold key to dating sedimentary rocks, researchers say
11. Humana Press journals now available on SpringerLink
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... SAN JOSE, Calif. , Jan. 20, 2016 ... leading developer of human interface solutions, today announced ... touch controller solution for wearables and small screen ... appliances such as printers. Supporting round and rectangular ... the S1423 offers excellent performance with moisture on ...
(Date:1/13/2016)... 2016 http://www.researchandmarkets.com/research/7h6hnn/india_biometrics ... the  "India Biometrics Authentication & Identification ...  report to their offering.  ... the addition of the  "India Biometrics ... & Forecast (2015-2020)"  report to ...
(Date:1/8/2016)... 2016 NXTD ), a company ... , a privately held leading direct seller of vacation ... 5000 fastest-growing company announced that on December 31, 2015, ... in Nxt-ID to develop a proprietary new wireless smart ... , a unique smart wallet that serves to securely ...
Breaking Biology News(10 mins):
(Date:2/6/2016)... ... February 06, 2016 , ... The Center for Excellence in ... and high school teachers on Wednesday February 10, 2016. This Bite of Science ... School of Conservation, located at 1500 Remount Road in Front Royal, VA from 5:00 ...
(Date:2/5/2016)... , Feb. 5, 2016  In the pharmaceutical ... for a host of launch activities including the identification ... this launch activity is especially high in the oncology ... Best Practices and the Role of Medical Affairs ... companies focused on oncology therapies find better ways to ...
(Date:2/5/2016)... Australian-US drug discovery and development company, Novogen Limited (ASX:NRT; NASDAQ: ... Chairman, Mr John O,Connor , and new Deputy Chairman, ... James Garner , has also been formally appointed to the ... Iain Ross , will resume his role on the ... , has also been formally appointed to the Board as ...
(Date:2/4/2016)... -- Sangamo BioSciences, Inc. (NASDAQ: SGMO ), the leader ... Lanphier , Sangamo,s president and chief executive officer, will ... Therapeutic ® development programs and an overview of ... Thursday, February 11, 2016, at the Leerink Partners 5 ... being held in New York . ...
Breaking Biology Technology: