Cold Spring Harbor, N.Y. Anthony Zador, Ph.D., Professor of Biology and Program Chair in Neuroscience at Cold Spring Harbor Laboratory (CSHL), has been awarded a $2.17 million, 5-year grant by the National Institutes of Health (NIH)'s Transformative Research Projects Program (T-R01). The T-R01 program, supported by the NIH Common Fund (formerly the NIH Roadmap for Medical Research), is a unique research opportunity that encourages researchers to rethink the way science is conducted and propose truly daring ideas.
"Complex research projects, even exceptionally high impact ones, are tough to get funded without the necessary resources to assemble teams and collect preliminary data. The TR01 awards provide a way for these high impact projects to be pursued," said NIH Director Francis S. Collins, M.D., Ph.D. Although these projects are deemed high-risk, they have the potential to create or overturn fundamental paradigms and impact a broad area of biomedicine.
Zador's T-R01 -funded research project is aimed at one of neuroscience's most fundamental, but as-yet-unknown entities: the 'connectome' or the complete wiring diagram of the brain. The brain is an extremely complex network, consisting of billions of neurons interconnected by trillions of synapses or junctions where electrical currents are transmitted. To understand brain function, detailed knowledge of these connectionsquestions such as which neurons connect synaptically with which other neurons, and where in the brain this interaction occursis critical.
"Disruption of this connectivity may cause many neuropsychiatric diseases including autism and schizophrenia, but only a minute fraction of these connections have been mapped to date," explains Zador. "The goal of my project is to develop a novel, high-throughput method to probe the connectivity of neural circuits at the level of individual neurons in mice." This method would allow Zador to analyze a large numbers of these connecti
|Contact: Hema Bashyam|
Cold Spring Harbor Laboratory