Navigation Links
Codeine not safe for all breastfeeding moms and their babies
Date:8/20/2008

Using pain treatments which contain codeine may be risky for some breastfeeding mothers, according to researchers at The University of Western Ontario, and the Hospital for Sick Children (SickKids) in Toronto. Lead author Dr. Gideon Koren published research in the journal, Clinical Pharmacology & Therapeutics which suggests that the codeine used in some pain relief drugs can actually have harmful and even fatal results for infants when ingested by some breastfeeding mothers.

"With nearly half of all infants in North America being delivered by caesarean section or after episiotomy, there is clearly a requirement for pain relief for mothers," says Koren. "However, our study confirms that codeine as a treatment for pain may be unsuitable and cannot be considered safe for all breastfed infants."

Koren holds the Ivey Chair in Molecular Toxicology at the Schulich School of Medicine & Dentistry at The University of Western Ontario, and is a professor of pediatrics at both Western and the University of Toronto. He is also a senior scientist in the Child Health Evaluative Sciences program at SickKids Research Institute, and director of The Motherisk Program.

Codeine is commonly used for pain relief and is recommended by the American Academy of Pediatrics as being compatible with breastfeeding. Following numerous reports through the Motherisk counseling service and the tragic death of an infant who died from an overdose of morphine acquired from breast milk, Koren and his team, located at SickKids and The University of Western Ontario, investigated these negative reactions.

Codeine is a 'prodrug' which means that on its own it is relatively inactive. The pain relieving attributes are only activated when it is metabolized, or transformed by the body into a more active pain relieving compound, morphine. Some individuals have a genetic variance which causes them to metabolize codeine at a rapid rate, producing significantly more morphine in their system than most of the population. While this genetic predisposition is rare, women who possess it and who take codeine for pain while breastfeeding can end up exposing their babies to high levels of morphine through their breast milk. This can cause babies to experience central nervous system depression as a result.

"The good news is that those breastfeeding children who were exposed to these high levels of morphine showed dramatic improvement once they were taken off the morphine tainted breast milk," says Koren. "By removing the exposure, most children will demonstrate a complete reversal of symptoms and show no long-term adverse effects."


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Related biology news :

1. New breastfeeding study shows most moms quit early
2. Early cessation of breastfeeding by HIV+ women in poor countries and child survival
3. Breastfeeding boost IQ in infants with helpful genetic variant
4. Parents shape whether their children learn to eat fruits and vegetables
5. Guilt on their hands: tiny tags could help to solve and deter gun crime
6. Male fish deceive rivals about their top mate choice
7. Syracuse University scientists discover how some bacteria may steal iron from their human hosts
8. Ultrasonic frogs can tune their ears to different frequencies
9. Pregnant mice block out unwelcome admirers to protect their pups
10. Researchers catch ion channels in their opening act
11. Children born after donor insemination should be told as soon as possible about their conception
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... 21, 2016 NuData Security announced today that ... of principal product architect and that Jon ... customer development. Both will report directly to ... moves reflect NuData,s strategic growth in its product ... customer demand and customer focus values. ...
(Date:6/9/2016)... in attendance control systems is proud to announce the introduction of fingerprint attendance control ... right employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... pleased to announce the launch of their brand, UP4™ Probiotics, into Target stores ... 35 years, is proud to add Target to its list of well-respected retailers. ...
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: