Navigation Links
Cocaine: How addiction develops
Date:8/21/2008

Permanent drug seeking and relapse after renewed drug administration are typical behavioral patterns of addiction. Molecular changes at the connection points in the brain's reward center are directly responsible for this. This finding was published by a research team from the Institute of Mental Health (ZI) in Mannheim, the German Cancer Research Center (DKFZ) in Heidelberg and the University of Geneva, Switzerland, in the latest issue of Neuron. The results provide researchers with new approaches in the medical treatment of drug addiction.

Addiction leaves detectable traces in the brain: In particular regions of the central nervous system, which produce the messenger substance dopamine, the drug cocaine causes molecular restructuring processes at the synapses, the points of connection between two neurons. As a reaction to the drug, protein subunits are exchanged in specific receptor complexes. As a result, the modified synapse becomes able to transmit nervous signals with enhanced strength a phenomenon that has been termed 'drug-induced synaptic plasticity'. Researchers have suspected for many years that drug-induced synaptic plasticity plays a crucial role in addiction development. However, this hypothesis has not yet been proven experimentally.

Using genetic engineering, researchers headed by Professor Dr. Gnther Schtz at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now been able to selectively switch off those protein components in dopamine-producing neurons that are integrated into the receptor complexes under the influence of cocaine. Jointly with the team of Professor Dr. Rainer Spanagel at the Central Institute of Mental Health (Zentralinstitut fr Seelische Gesundheit, ZI) in Mannheim and the research group of Professor Dr. Christian Lscher at Geneva University, the Heidelberg researchers studied the changes in physiology and behavior of the genetically modified animals.

The scient
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nicotinic receptors may be important targets for treatment of multiple addictions
2. New genetic research into nicotine addiction shows promise for personalized treatment
3. Can plant-based ethanol save us from our fossil fuel addiction?
4. Cognitive, genetic clues identified in imaging study of alcohol addiction
5. Hungry mothers risk addiction in their adult children
6. Corals addiction to junk food
7. Erasing drug-associated memories may stop drug addiction relapses
8. Large-scale investment catapults CAMHs mental illness and addiction research forward
9. How schizophrenia develops: Major clues discovered
10. MIT develops tractor beam for cells, more
11. Team of scientists develops non-invasive method to track nerve-cell development in live human brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... world-leading provider of scientific, technical and medical information ... Society (ARMS), recognized the academic research achievements of ... Researcher of the Year Awards. , The award ... Centre and in conjunction with the ARMS 2014 ... and New Zealand,s scientific community. Guest of honour ...
(Date:9/18/2014)... can swim up to 400 kilometres in search of a ... change. , Clownfish spend their entire adult lives under the ... wander the open ocean, says study co-author, Dr Hugo Harrison ... (Coral CoE) at James Cook University. , "In the past ... given a rare glimpse into how far they can swim, ...
(Date:9/17/2014)... the Arts and Humanities has received a $260,000 grant ... project, "The Boundaries of the Human in the Age ... a wide-ranging series of events aimed at exploring two ... artists and researchers who are exploring the boundaries of ... humanism, and the other involves the increasingly influential hypothesis ...
Breaking Biology News(10 mins):Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Nemo's epic journey to find a new home 2Mellon Foundation awards grant for major project in the humanities and sciences 2
... 31 January 2014 VIB and CD3 (KU Leuven) ... agreement with AstraZeneca for the development of novel MALT1 ... The research teams of Thijs Baens and Peter ... Beyaert (VIB-UGent, Inflammation Research Center) were among the first ...
... University have just published a comprehensive overview of forensic research ... "By pulling all of this information together in one ... some children and find justice for others," says Dr. Ann ... author of the paper. Ross is also co-editor of the ...
... were domesticated more than 15,000 years ago and it ... to form close relationships with humans stems from changes ... on the interactions between the animals have not received ... Range and Zsfia Virnyi, two members of the University ...
Cached Biology News:VIB&CD3 enter into license and collaboration agreement with AstraZeneca for development of MALT1 inhibitor 2Forensic experts compile guide on how to ID child abuse, starvation 2Teaching young wolves new tricks 2
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
(Date:9/18/2014)...  Neogen Corporation (Nasdaq: NEOG ) announced ... with Merck Animal Health to market Neogen,s Igenity ® ... Dairy Heifer Program consists of genomic tests that offer ... of replacement dairy heifers. The genomic tests can be ... an excellent tool in the decision-making process for breeding ...
(Date:9/18/2014)... YARDLEY , Pennsylvanie, 18 septembre 2014 ... Lyon en 1974, a été ... à compléter les évaluations cliniques traditionnelles par ... Reported Outcomes) et sur les impacts économiques ... http://photos.prnewswire.com/prnh/20140618/119365 A cours ...
(Date:9/18/2014)... OMICS Group International invites researchers, authors and ... ‘Open Access Week’ by actively contributing their research ... Journals from 20-26th October, 2014. , Pharmaceutical ... accelerating with a tremendous speed to provide improved ... industry is gearing with innovation and technological revolution ...
Breaking Biology Technology:Kultevat obtains license of gene switch technology 2Merck Animal Health to market Neogen's dairy genomic program 21974 - 2014 - Mapi fête ses 40 ans 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... Feb. 21 AstraZeneca,believes this lawsuit is legally and ... Supreme Court, if the trial court does not reject ... premise that the,Alabama State Medicaid Agency did not understand ... We believe numerous errors occurred during the proceedings ...
... Today, Nycomed US Inc.,successfully completed the acquisition ... therapeutic markets in the United States. With,this acquisition, ... offered through its PharmaDerm Division and thereby increase,market ... Fougera,Division, which is a leader in the topical ...
... Cardinal Health, a,global provider of products and services ... announced an order by the New York,Department of Health ... expanding statewide plan to maintain emergency response readiness, New,York ... over the past two years., Cardinal Health has ...
Cached Biology Technology:Nycomed US Inc. Acquires Bradley Pharmaceuticals, Inc. 2New York Strengthens Emergency Preparedness with Cardinal Health Ventilators 2
...
Agarose for baculovirus plaque assays which allow optimal growth of plated insect cells....
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Mycoplasma and virus tested...
Biology Products: