Navigation Links
Cobblestones fool innate immunity
Date:11/29/2011

Coating the surface of an implant such as a new hip or pacemaker with nanosized metallic particles reduces the risk of rejection, and researchers at the University of Gothenburg, Sweden, can now explain why: they fool the innate immune system. The results are presented in the International Journal of Nanomedicine.

"Activation of the body's innate immune system is one of the most common reasons for an implant being rejected," explains Professor Hans Elwing from the University of Gothenburg's Department of Cell and Molecular Biology. "We can now show why the body more easily integrates implants with a nanostructured surface than a smooth one."

The researchers used a unique method to produce nanostructures on gold surfaces, creating gold particles just 10-18 nm in diameter and binding them to a completely smooth gold surface at carefully regulated distances. The result is something akin to a cobbled street in miniature.

Nanosized irregularities mimic body's natural structures

Giving implants this cobbled surface reduces the activation of important parts of the innate immune system. This is because several of the proteins involved are of a similar size to these nanosized cobbles, and so do not change in appearance when they land on the surface. This gives the body a greater ability to integrate foreign objects such as implants, pacemakers and drug capsules into its own tissues, as well as reducing the risk of local inflammation.

"It may be that the innate immune system is designed to react to smooth surfaces, because these are not found naturally in the body," says Elwing. "Some bacteria, on the other hand, do have a completely smooth surface."

Modern nanotechnology makes it easy and cheap to surface-treat implants and drug capsules, but it will probably be several years before this becomes a reality in human medicine. The focus now is on customising titanium implants of various kinds.

Surface can be graded

"We've developed a graded surface with different cobbelstone package that we think can be used for bone implants," says Elwing. "Bone is very hard on the outside but then gets softer, so it would be good to have hard integration on the surface and softer integration underneath. We reckon we can make titanium screws that are denser at the head of the screw so that they fuse best at the top. This kind of customisation is the future."

Research into the body's innate immune system was rewarded this year with the Nobel Prize in Physiology or Medicine.


'/>"/>

Contact: Hans-Bjrne Elwing
hans.elwing@cmb.gu.se
46-031-786-2562
University of Gothenburg
Source:Eurekalert

Related biology news :

1. Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
2. A new player in the innate immunity game?
3. New discovery suggests our lungs are innately prone to silicosis and related diseases
4. New research shows how disease-causing parasite gets around human innate immunity
5. Papillomavirus silences innate immune response
6. Brain innately separates living and non-living objects for processing
7. NIH funds $9.5 million for research on HIV and the human innate immune system
8. Facial expressions of emotion are innate, not learned, says new study
9. Genetic finding implicates innate immune system in major cause of blindness
10. New research aims to shed light on how aging affects immunity
11. Hydrogen peroxide provides clues to immunity, wound healing and tumor biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
(Date:12/8/2016)... Dec. 8, 2016  Singulex, Inc., the leader in ... entered into a license and supply agreement with Thermo ... agreement provides Singulex access to Thermo Scientific BRAHMS PCT ... is used to diagnose systemic bacterial infection and ... to aid in assessing the risk of critically ...
(Date:12/6/2016)... , Dec. 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE ... priced an offering of €500.0 million principal amount of its ... amount of its 2.425% senior unsecured notes due 2026. ... occur on December 13, 2016, subject to the satisfaction of customary ... basis. The Company intends to ...
Breaking Biology News(10 mins):
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci has been ... found among its diverse customer base. The latest entry in this field is ... including BTX and Bio-Rad. FireflySci is introducing three distinct varieties including a 10x1mm, ...
(Date:1/12/2017)... North Carolina (PRWEB) , ... January 12, 2017 , ... ... called the Eureka Index – a process that evaluates the patent estate of a ... Immunolight LLC , a biomedical firm leading the way in technologies that transform ...
(Date:1/12/2017)... ... 2017 , ... After her brain cancer became resistant to ... a few months to live. Now a paper publishing January 17 in the ... increased both the quantity and quality of her life: Adding the anti-malaria drug ...
(Date:1/12/2017)... Pune, India , January 12, 2017 A new report ... and End Users - Global Opportunity Analysis and Industry Forecast, 2014-2022," projects that the ... million in 2015, growing at a CAGR of 15.07% during the forecast period. ... ... Research Logo ...
Breaking Biology Technology: