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Co-transplanted cells and treadmill training aids rats with spinal cord injury
Date:11/25/2013

previous studies, the SCs remained densely packed and concentrated at the injection site while the OECs migrated through the gray and white matter. Both kinds of cells induced axon growth and remyelination, but it appeared that the treadmill training was responsible for improving hind leg function and neuron plasticity, though a further synergistic improvement was seen with the combined therapy.

"Treadmill training may reflect significant up-regulation of the TH+ expression in intrinsic interneuronal neurons and a switch by other neurons to a TH phenotype, revealing an interneuron and motoneuron plastic response to treadmill training within the spinal cord," the researchers concluded.

"This study highlights the benefits of combinatorial therapies of cell transplantation and exercise, where multiple factors can impact on improving a neurodegenerative disorder" said Dr. Paul R. Sanberg, distinguished professor at the Center of Excellence for Aging and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL. "Once further elucidation of the individual and synergistic contributions of each treatment has been made, translation of such combinatorial therapies to the clinical setting will hopefully yield similar results."


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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