CORVALLIS, Ore. A laboratory study has shown for the first time that coenzyme Q10 offsets the cellular changes that are linked to a side-effect of some statin drugs - an increased risk of adult-onset diabetes.
Statins are some of the most widely prescribed drugs in the world, able to reduce LDL, or "bad" cholesterol levels, and the risk of heart attacks or other cardiovascular events. However, their role in raising the risk of diabetes has only been observed and studied in recent years.
The possibility of thousands of statin-induced diabetics is a growing concern, which led last year to new labeling and warnings by the Food and Drug Administration about the drugs, especially when taken at higher dosage levels.
The findings of the new research were published as a rapid communication in Metabolic Syndrome and Related Disorders, and offer another clue to a possible causative mechanism of this problem.
Pharmacy researchers at Oregon State University who authored the study said the findings were made only in laboratory analysis of cells, and more work needs to be done with animal and ultimately human studies before recommending the use of coenzyme Q10 to help address this concern.
"A number of large, randomized clinical trials have now shown that use of statins can increase the risk of developing type-2 diabetes by about 9 percent," said Matthew K. Ito, an OSU professor of pharmacy and president-elect of the National Lipid Association.
"This is fairly serious, especially if you are in the large group of patients who have not yet had a cardiovascular event, but just take statin drugs to lower your risks of heart disease," Ito said.
A suspect in this issue has been altered levels of a protein called GLUT4, which is part of the cellular response mechanism, along with insulin, that helps to control blood sugar levels. A reduced expression of GLUT4 contributes to insulin resistance and the onset of ty
|Contact: Matthew K. Ito|
Oregon State University