Navigation Links
Clumps of red and white blood cells may contribute to sickle cell disease
Date:4/28/2008

CHAPEL HILL Its long been known that patients with sickle cell disease have malformed, sickle-shaped red blood cells which are normally disc-shaped that can cause sudden painful episodes when they block small blood vessels.

Now, researchers at the University of North Carolina at Chapel Hill School of Medicine have shown that blood from sickle cell patients also contains clumps, or aggregates, of red and white blood cells that may contribute to the blockages.

The study, published on-line April 18 in the British Journal of Haematology, marks the first time that aggregates made up of red blood cells and white blood cells have been found in whole blood from sickle cell patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin alpha four beta one.

First author Julia E. Brittain, Ph.D., a research assistant professor in the medical schools department of biochemistry and biophysics, said further study could lead to new treatments for the disease. If the blockages are caused by these chunks of aggregates that are circulating in the blood, and we know how the aggregates are sticking together, we potentially could design drugs to disrupt the aggregates so that they pass through the blood vessel more freely, she said.

Normal red blood cells dont interact with white blood cells. But Brittain first showed in lab tests with isolated cells that young red blood cells (reticulocytes) would interact with white blood cells and form aggregates with them. Then, she looked for such clumps in blood samples from 14 people with sickle cell disease. All the patient samples studied had clumps, though some had only a few, while others had thousands. She didnt see clumps in samples from patients without sickle cell disease.

Brittain said other researchers may have disrupted the aggregates because blood collection tubes usually contain an anticoagulant
'/>"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. New whitepaper offers options for university implementation of NIH policy
2. Unveiling the underwater ways of the white shark
3. ESA honored at White House ceremony
4. Menstrual blood -- a valuable source of multipotential stem cells?
5. Effective cancer immune therapy through order in the blood vessels
6. Bloodless worm sheds light on human blood, iron deficiency
7. Mental stress reduces blood flow to the heart in patients with gene variation
8. Backpack straps can decrease blood flow in the shoulder and arm
9. Yale study shows how rare genes have big impact on blood pressure
10. T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
11. Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... July 1, 2014 Smart technology emphasis ... convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. ... GOOG ), Apple Inc. (NASDAQ: AAPL ), Visa ... MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company ... that the second series of 30 second spots on CNBC ...
(Date:7/10/2014)... 2, 2014 It is a great honor ... appointment of the world-renowned Thoracic and Cardiovascular surgeon, Mark ... Dr. Ginsburg, with over 34 years of experience, ... and Good Samaritan Regional Medical Center. Dr. Ginsburg has ... 1980,s and is considered an expert in the implantation ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
... http://www.ptitime.com ), an established leader in manufacturing Time ... Generation II,an innovative biometric system that features a ... generation of Pyramid,s TimeTrax Bio was,released in January ... same,features as its predecessor with one-touch time and ...
... of "New Employee,Verification Act", ALEXANDRIA, Va., May ... resource management today led a coalition of,business leaders ... Act." In testimony today before the House Ways ... and CEO of SHRM,urged legislators to recognize that ...
... Chicago, Ill. May 6, 2008 A recent study ... dramatically between 1990 and 2005, but that they continue to ... products contributes nearly one-third of total mercury emissions to the ... into the relative magnitudes of the different sources of mercury ...
Cached Biology News:Pyramid Launches TimeTrax Bio Generation II 2SHRM CEO Testifies Before House Subcommittee on Social Security 2SHRM CEO Testifies Before House Subcommittee on Social Security 3Study shows mercury levels from products decreasing, though still at dangerous levels 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... 10, 2014 EvoDerma ’s NOOME Anti-Aging ... rejuvenating device now comes with a second treatment cup to ... , The new cup is thinner on the edges for ... target rough, thin and uneven surfaces on the face, neck ... a stimulating treatment on areas such as the cheeks and ...
(Date:7/10/2014)... PETERSBURG, Russia , July 10, 2014 ... Russian Federation Dmitry Medvedev , presented ... biopharmaceutical company BIOCAD . The Company is developing ... scope of MabNext project BIOCAD develops a number of ... cancer and autoimmune diseases. The ceremony took place at ...
(Date:7/10/2014)... July 10, 2014 Research and Markets ... the "International Photonic Integrated Circuit (Monolithic Integration, ... 2019" report to their offering. ... concept of photonic integration traces its roots in ... promise of photonic integration went unexplored and unfulfilled ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2
... tracking are not quite here yet. But Pete Abell ... has a few words to say about when they might ... UW E-Business Institute held June 17 near Waukesha, he told ... RFID tracking as early as next year so they would ...
... disadvantages and implementation advice offered , ,Waukesha, Wis. ... open market, it seldom begins its life as an instant ... or impractical contraption that is waiting for early adopters, who ... must be studied by those experienced in the field, tested ...
... Third CATI company in 12 months , ,STURTEVANT, ... technology licensed from the Center for Advanced Technology ... a license agreement with CATI on its flexible, raised-pavement ... Bates. , ,Raised pavement markers are installed on most ...
Cached Biology Technology:RFID: a 30-year project 2Laying the foundation for RFID 2Laying the foundation for RFID 3Laying the foundation for RFID 4
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
acridine orange 10-nonyl bromide (nonyl acridine orange)...
anti-dansyl, rabbit IgG fraction *1 mg/mL* Secondary Detection; Anti-Dye and Anti-Hapten Antibodies...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: