Navigation Links
Clumps of red and white blood cells may contribute to sickle cell disease
Date:4/28/2008

CHAPEL HILL Its long been known that patients with sickle cell disease have malformed, sickle-shaped red blood cells which are normally disc-shaped that can cause sudden painful episodes when they block small blood vessels.

Now, researchers at the University of North Carolina at Chapel Hill School of Medicine have shown that blood from sickle cell patients also contains clumps, or aggregates, of red and white blood cells that may contribute to the blockages.

The study, published on-line April 18 in the British Journal of Haematology, marks the first time that aggregates made up of red blood cells and white blood cells have been found in whole blood from sickle cell patients. The study also shows how the red and white blood cells adhere to one another: the interaction is mediated by a particular protein, integrin alpha four beta one.

First author Julia E. Brittain, Ph.D., a research assistant professor in the medical schools department of biochemistry and biophysics, said further study could lead to new treatments for the disease. If the blockages are caused by these chunks of aggregates that are circulating in the blood, and we know how the aggregates are sticking together, we potentially could design drugs to disrupt the aggregates so that they pass through the blood vessel more freely, she said.

Normal red blood cells dont interact with white blood cells. But Brittain first showed in lab tests with isolated cells that young red blood cells (reticulocytes) would interact with white blood cells and form aggregates with them. Then, she looked for such clumps in blood samples from 14 people with sickle cell disease. All the patient samples studied had clumps, though some had only a few, while others had thousands. She didnt see clumps in samples from patients without sickle cell disease.

Brittain said other researchers may have disrupted the aggregates because blood collection tubes usually contain an anticoagulant that ties up calcium, which often plays a role in cell adhesion. She saw the aggregates only when she used an anticoagulant that doesnt remove calcium.

Brittain and her colleagues plan further study of the phenomenon, including the conditions that might determine the number of aggregates in the blood, and whether they are affected by the drug hydroxurea, which is commonly used to treat sickle cell disease.


'/>"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Related biology news :

1. New whitepaper offers options for university implementation of NIH policy
2. Unveiling the underwater ways of the white shark
3. ESA honored at White House ceremony
4. Menstrual blood -- a valuable source of multipotential stem cells?
5. Effective cancer immune therapy through order in the blood vessels
6. Bloodless worm sheds light on human blood, iron deficiency
7. Mental stress reduces blood flow to the heart in patients with gene variation
8. Backpack straps can decrease blood flow in the shoulder and arm
9. Yale study shows how rare genes have big impact on blood pressure
10. T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
11. Umbilical cord blood cell therapy may reduce signs and symptoms of Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:8/11/2017)... (PRWEB) , ... August 11, 2017 , ... ... food production, and, in particular, more natural alternatives to synthetic ingredients,” said Matt ... of Third Wave, with the established manufacturing presence and know-how of Biorigin will ...
(Date:8/10/2017)... ... August 09, 2017 , ... Teachers from ... students. From August 14th through the 16th, the University City Science Center will ... summer of 2016, provides Philadelphia-based middle school educators an opportunity for professional development ...
(Date:8/10/2017)... ... 09, 2017 , ... Each year in the United States more than 300,000 ... an independent lifestyle and, even worse, the one-year mortality rate is high, ranging from ... University of California Davis Medical Center (Sacramento) and Second Xiangya Hospital of the Central-South ...
(Date:8/10/2017)... California, USA (PRWEB) , ... August 09, 2017 ... ... has partnered with four international biomedical optics laboratories — the Wellman Center for ... Hospital, Medical Laser Center Lübeck and the Beckman Laser Institute at University of ...
Breaking Biology Technology: