Navigation Links
Clues to cancer pathogenesis found in cell-conditioned media
Date:2/9/2014

Philadelphia, PA, February 10, 2014 Primary effusion lymphoma (PEL) is a rare B-cell neoplasm distinguished by its tendency to spread along the thin serous membranes that line body cavities without infiltrating or destroying nearby tissue. By growing PEL cells in culture and analyzing the secretome (proteins secreted into cell-conditioned media), investigators have identified proteins that may explain PEL pathogenesis, its peculiar cell adhesion, and migration patterns. They also recognized related oncogenic pathways, thereby providing rationales for more individualized treatment. The results are published in The American Journal of Pathology.

A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, a condition, or disease, and can help develop personalized therapeutic approaches for patients. Analysis of secretomes is a new strategy for discovering biomarkers involved in cancer pathogenesis based on the reasoning that these fluids will be enriched in proteins secreted by cancer cells, shed from cancer cell surfaces, or released from the interior of cells (through vesiculation, cell lysis, apoptosis, or necrosis). The content of the secretome may reflect the functional state of the cells at a specific time point.

In this study, investigators from the Istituto Nazionale dei Tumori of Milan and the Centro di Riferimento Oncologico of Aviano, Italy, analyzed secretomes from four established PEL cell lines (CRO-AP2, CRO-AP3, CRO-AP5, and CRO-AP6; established in the laboratories directed by Antonino Carbone, MD) as well as from four PEL clinical samples and three primary solid lymphomas. PEL tumor cells are characterized by Kaposi's sarcoma-associated herpesvirus (KSHV) infection, and the primary solid lymphomas were also KSHV-positive.

Protein content was measured using two complementary mass spectrometry platforms. The experiments allowed cells to grow f
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study involving twin sisters provides clues for battling aggressive cancers
2. Space flies offer clues about microgravitys impact on astronauts
3. Joslin finds metabolic clues to diabetic kidney failure
4. Study offers clues to how plants evolved to cope with cold
5. Stanford scientists probe abandoned mine for clues about permanent CO2 sequestration
6. New clues to memory formation may help better treat dementia
7. Swarming insect provides clues to how the brain processes smells
8. Clemson research finds chickens offer clues to human birth defects
9. In plant photosynthesis, scientists see clues for improving solar energy cells
10. Poultry probiotics coat clues to ability to battle bugs
11. Temple researchers uncover clues to how existing heart drugs work
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... International Glossina Genome Initiative (IGGI) has produced the first ... morsitans . The blood-sucking insect is the sole transmitter ... sub-Saharan Africa. The vast store of genetic data will ... and provide insights into the tsetse fly,s unique biology. ... insect world: it feeds exclusively on the blood of ...
(Date:4/24/2014)... 2014D-ribose is a commercially important sugar used as ... starting compound for synthesizing riboflavin and several antiviral ... to increase the bacteria,s ability to produce D-ribose ... industrial-scale production of this valuable chemical, as described ... a peer-reviewed journal from Mary Ann Liebert, Inc., ...
(Date:4/24/2014)... Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified ... system to discriminate between viral and endogenous RNAs ... they take control of cellular metabolism and hijack ... This process is dependent on viral RNA molecules ... of RNA viruses) and/or newly synthesized in the ...
Breaking Biology News(10 mins):Genetic code of the deadly tsetse fly unraveled 2Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3
... from Boston College have developed a new class of ... that reveals the telltale signs of cellular death, particularly ... in the current electronic edition of the Journal ... by Assistant Professor of Chemistry Jianmin Gao successfully grafted ...
... fuel economy is on everyone,s minds these days. The ... is no exception. For several years, the transit authority, ... fleet in an effort to curb the transportation system,s fuels costs. ... hybrids is the question the University of Houston has been asked ...
... of California, Berkeley, are offering hope to the 10 percent ... often high-pitched ringing or buzzing in the ears that can ... Their new findings, published online last week in the journal ... several new approaches to treatment, including retraining the brain, and ...
Cached Biology News:Small molecule receptor detects lipid's telltale sign of cell death 2University of Houston to test local buses for fuel efficiency 2Tinnitus discovery could lead to new ways to stop the ringing 2Tinnitus discovery could lead to new ways to stop the ringing 3
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
(Date:1/14/2014)... 14, 2014 As pet owners drew up their lists of ... wrote: "Take better care of my furry companion." Nowadays there are ... top-brand carrying cases to take the little canine or feline darlings ... compelled to buy some pricey toys at the pet store. But ...
(Date:1/14/2014)... SAN DIEGO and BETHESDA, Md. ... they are joining together with two institutes from the ... more reliable tools for bringing safer, more effective treatments ... with the National Center for Advancing Translational Sciences (NCATS) ...
(Date:1/14/2014)... Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), ... commercializing innovative therapies addressing major unmet medical needs ... the Notice of Allowance from the United States ... RNAi compounds (sd-rxRNA®), for the treatment of fibrosis. ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... Services Inc., leads a videocast discussion with top executives on ... to Asia. , ... (PRWEB) November ... Atlanta, Georgia, Jim Miller, president of PharmSource Information Services Inc., ...
... Arpida,announced today that it is refocusing all projects and ... is to be seen as a,consequence of the negative recommendation ... 20 November 2008 regarding the,approval of Iclaprim in the U.S. ... of the FDA advisory board,s recommendation the Arpida,board intends to ...
... sailing a spacecraft by the optical force of the sun,s light. ... the oversized sails that have been tried. Now a team led ... Science has shown that the force of light indeed can ... to nano-proportions. , Their work opens the door to a ...
Cached Biology Technology:PharmSource President Moderates Videocast on Outsourcing to Asia at AAPS 2Arpida to Restructure and Focus on Key Projects 2'The photon force is with us': Harnessing light to drive nanomachines 2
... The Synaptic Vesicles Isolation Kit ... preparing an enriched synaptic vesicle fraction. ... hypo-osmotic lysis of the synaptosomes, and ... density gradient. The kit also contains ...
... The Ultra Silica Bead Kit has been designed ... gels and solutions. Features Ultra ... minutes Uniform silica beads are easy to resuspend ... DNA Highly pure DNA (suitable for PCR) ...
... simple and efficient method for purification of DNA ... DNA fragments selectively absorbed in the spin column ... at room temperature for PCR product with equal ... of DNA can be purified with a single ...
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
Biology Products: