Navigation Links
Clues point to cause of a rare fat-distribution disease
Date:3/20/2013

mino acid sequence for predicted binding sites and found five. Using targeted genetic techniques, they created lamin A variants, each with a mutation at a different predicted SUMO1 attachment site. They then added SUMO1 to the mutants and tested whether it could attach to them or not.

Two mutations significantly decreased SUMO1 attachment. One was at a predicted site; the other was unexpectedly in their comparison "control" variant. "Since the mutation site in our control variant was not a predicted SUMO1 attachment site, we were curious about it," explains Wilson. "Mutations in lamin A cause more than 15 different diseases, so we checked the genetic database to see if any diseases were associated with mutations near the SUMO1 attachment site, and FPLD leapt out like a neon sign."

FPLD is a very rare condition that starts around puberty. Fat on the legs of patients is reduced while it accumulates at other locations, including the neck and face. Patients can also become diabetic.

Twenty-four different mutations in lamin A can cause FPLD. To see if two other FPLD-causing mutations near the SUMO1 attachment site affected SUMO1 attachment, the team created these variants and tested them as before. One of the new variants did show decreased SUMO1 attachment. Based on the location of that mutation and one of the other SUMO1-disrupting mutations, the researchers were able to identify a "patch" on the surface of the lamin A protein that is important for SUMO1 attachment.

Exactly how lamin A and SUMO1 connect to FPLD is still a mystery. "We can only speculate on how lamin A and SUMO1 work together to regulate fat cells," says Wilson. "But these results raise new research questions that will hopefully move FPLD studies forward."


'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clues to chromosome crossovers
2. USC researchers find possible genetic clues to organ development, birth defects
3. Climate change clues from tiny marine algae -- ancient and modern
4. The genome of diamondback moth provides new clues for sustainable pest management
5. Heat-resistant corals provide clues to climate change survival
6. New findings in the search for genetic clues to insulin production
7. Unraveling the threads: Simplest cotton genome offers clues for fiber improvements
8. Emerging virus in raccoons may provide cancer clues
9. Mining ancient ores for clues to early life
10. Genome decoded: Scientists find clues to more disease-resistant watermelons
11. Watching the developing brain, scientists glean clues on neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... State University researchers have completed a 20-year study ... Hills prairie at different times of the year. ... late spring time frame has no measurable negative ... have multiple benefits. , The study was conducted ... Prairie Biological Station fire chief, and Joseph Craine, ...
(Date:7/31/2014)... German . , ... a sponge that soaks up liquids. Hence, these highly ... gases. However, loading of many MOFs is inhibited by ... report in Nature Communications that the barriers ... can be prevented by water-free synthesis and storing strategies. ...
(Date:7/31/2014)... July 31, 2014 -- Do people make a rational ... raise them that way? Is it a matter of ... and a colleague from Rice University say that neither ... people lean left while others lean right. , A ... deep-seated psychology are at the core of political differences, ...
Breaking Biology News(10 mins):Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3Free pores for molecule transport 2Scientists find growing consensus: Political attitudes derive from body and mind 2
... COLLEGE STATION A team of scientists studying the ... has had its research published in the February issue ... Microbiology , said the study,s lead investigator. The ... illness through the use of electron-beam irradiation. "The ...
... have developed a methodology for governments and corporations to ... paper in Environmental Science & Technology . ... the importance of scarce metals using a methodology that ... supply restriction. "In the past few years, ...
... in German . To explore the most ... functions Stefan Hell,s team of researchers at the Max Planck ... closer to this goal. Using the STED microscopy developed by Hell, ... live images inside the brain of a living mouse. Captured in ...
Cached Biology News:Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach 2Study shows electron-beam irradiation reduces virus-related health risk in lettuce, spinach 3New methodology assesses risk of scarce metals 2Sharp images from the living mouse brain 2Sharp images from the living mouse brain 3
(Date:8/1/2014)... -- Cambrex Corporation (NYSE: CBM ) reports results ... Highlights , Second quarter sales increased 59% ... last year. , Second quarter EBITDA increased 86% to ... last year (see table at the end of this release). ... impact of foreign currency, to between 13% and 16% over ...
(Date:7/31/2014)... August 01, 2014 “2014 ... Polyurethane Resin Industry” is a professional and ... The report introduces Polyurethane Resin basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
(Date:7/31/2014)... is famous for a number of breakthroughs, which altered ... published a paper, which laid the foundation of computer ... algorithm. He next played a pivotal role in the ... German military codes, enabling the Allies to defeat the ... 1940,s he turned his attention to artificial intelligence and ...
(Date:7/31/2014)... COLORADO SPRINGS, Colo. , July 31, 2014 ... Seed Grant awardee today with $25,000 to fund ... the Foundation,s inception in 2011, the gift was ... 11 th Annual Meeting in ... physicians who specialize in neurointerventional approaches to neurovascular ...
Breaking Biology Technology:Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3
... Adjusted EBITDA Up 70% Year-Over-Year, SHANGHAI, China, ... WX ), a leading pharmaceutical, biotechnology and,medical ... China and the United States, today announced its ... 30, 2008. During the quarter,WuXi,s net revenue increased ...
... Melbourne-based Starfish,Ventures announced today the successful closure of ... largest venture capital fundraising in,Australia. The fund will ... The success of this fundraising is an endorsement ... to foster the development of,innovative companies that, with ...
... Beckman,Coulter, Inc. (NYSE: BEC ), ... that simplify, automate, and innovate complex biomedical,testing, ... senior vice,president and chief financial officer, will ... Healthcare Conference on Tuesday, November 18, 2008 ...
Cached Biology Technology:WuXi PharmaTech Announces Third Quarter 2008 Results 2WuXi PharmaTech Announces Third Quarter 2008 Results 3WuXi PharmaTech Announces Third Quarter 2008 Results 4WuXi PharmaTech Announces Third Quarter 2008 Results 5WuXi PharmaTech Announces Third Quarter 2008 Results 6WuXi PharmaTech Announces Third Quarter 2008 Results 7WuXi PharmaTech Announces Third Quarter 2008 Results 8WuXi PharmaTech Announces Third Quarter 2008 Results 9WuXi PharmaTech Announces Third Quarter 2008 Results 10WuXi PharmaTech Announces Third Quarter 2008 Results 11WuXi PharmaTech Announces Third Quarter 2008 Results 12WuXi PharmaTech Announces Third Quarter 2008 Results 13Starfish Ventures Closes Australia's Largest Venture Capital Fund With $185 Million Tech Fund 2
The HQ505, 20 OptiGreen filter for the Molecular Imager FX is a band pass filter used for detection of Cy2 and FITC with 532 nm excitation....
... The APO-BRDU Kit is a 2-color staining ... cellular DNA to detect apoptotic cells by ... and reagents required for measuring apoptosis in ... for assessing reagent performance; washing, reaction and ...
... ApopTag Red In Situ Apoptosis Detection ... the indirect TUNEL method, utilizing an ... The kit provides indirect immunofluorescence staining ... using either fluorescence microscopy or flow ...
The sample holders for gels are used to hold gels in place in the multi-sample tray I, which is used with Molecular Imager FX imaging systems....
Biology Products: